Bibliographic Citation
| Document |  294 K |
|---|---|
| Title | High-level production of C-11-carboxyl-labeled amino acids. [For use in tumor and pancreatic imaging] |
| Creator/Author | Washburn, L.C. ; Sun, T.T. ; Byrd, B.L. ; Hayes, R.L. ; Butler, T.A. ; Callahan, A.P. |
| Publication Date | 1979 Jan 01 |
| OSTI Identifier | OSTI ID: 6298908 |
| Report Number(s) | CONF-790321-4 |
| DOE Contract Number | W-7405-ENG-26 |
| Resource Type | Conference |
| Specific Type | Technical Report |
| Resource Relation | Conference: 2. international symposium on radiopharmaceuticals, Seattle, WA, USA, 18 Mar 1979 |
| Research Org | Oak Ridge Associated Universities, Inc., TN (USA). Medical and Health Science Div.; Oak Ridge National Lab., TN (USA) |
| Subject | 38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; AMINO ACIDS; LABELLING; CARBON 11; BIOLOGICAL LOCALIZATION; ECAT SCANNING; RADIOCHEMISTRY; NEOPLASMS; DIAGNOSIS; PANCREAS; RADIOPHARMACEUTICALS; CHEMICAL PREPARATION; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; CARBON ISOTOPES; CARBOXYLIC ACIDS; CAT SCANNING; CHEMISTRY; DIAGNOSTIC TECHNIQUES; DIGESTIVE SYSTEM; DISEASES; DRUGS; ENDOCRINE GLANDS; EVEN-ODD NUCLEI; GLANDS; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MINUTES LIVING RADIOISOTOPES; NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; PHOTON EMISSION SCANNING; PHOTON TRANSMISSION SCANNING; RADIOACTIVE MATERIALS; RADIOISOTOPES; SYNTHESIS; TOMOGRAPHY |
| Description/Abstract | Carbon-11-labeled amino acids have significant potential as agents for positron tomographic functional imaging. We have developed a rapid, high-temperature, high-pressure modification of the Buecherer--Strecker amino acid synthesis and found it to be quite general for the production of C-11-carboxyl-labeled neutral amino acids. Production of C-11-carboxyl-labeled DL-tryptophan requires certain modifications in the procedure. Twelve different amino acids have been produced to date by this technique. Synthesis and chromatographic purification require approximately 40 min, and C-11-carboxyl-labeled amino acids have been produced in yields of up to 425 mCi. Two C-11-carboxyl-labeled amino acids are being investigated clinically for tumor scanning and two others for pancreatic imaging. Over 120 batches of the various agents have been produced for clinical use over a three-year period. |
| Country of Publication | United States |
| Language | English |
| Format | Size: Pages: 13 |
| Availability | Dep. NTIS, PC A02/MF A01. |
| System Entry Date | 2008 Aug 28 |
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