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Treponema denticola Search Results

Record: 1 of 1 MiniMap

Gene ID:TDE0590DNA Molecule Name: 1 GenBank ID: 42526106Gene Name: accD Definition: acetyl-CoA carboxylase carboxyl transferase subunit betaCellular Location: Cytoplasm [Evidence]Gene Start: 629946Gene Stop: 629158Gene Length: 813Molecular Weight*: 29983pI*:Net Charge*:EC: 6.4.1.2 Functional Class: Fatty acid and phospholipid metabolism; Other Gene Ontology:Pathway: pathway table Fatty acid biosynthesis (path 1) Propanoate metabolism Pyruvate metabolism Tetracycline biosynthesisSecondary Evidence: Levert KL, Waldrop GL. A bisubstrate analog inhibitor of the carboxyltransferase component of acetyl-CoA carboxylase. Biochem Biophys Res Commun. 2002 Mar;291(5):1213-7. PMID: 11883946 Kimura Y, Miyake R, Tokumasu Y, Sato M. Molecular cloning and characterization of two genes for the biotin carboxylase and carboxyltransferase subunits of acetyl coenzyme A carboxylase in Myxococcus xanthus. J Bacteriol. 2000 Oct;182(19):5462-9. PMID: 10986250Comment: Related 'acc' genes are the acetyl-CoA carboxylase, biotin carboxyl carrier protein (bccP/accB) TDE0592, biotin carboxylase subunit (accC) TDE0591 and the alpha subunit (accA) TDE0589.View in HOMD Genome ViewerBlast Summary: PSI-Blast Search TDE0590 has no significant similarity (BLAST p-value < 1e-03) to a Treponema pallidum gene. TDE0590 has no significant similarity (BLAST p-value < 1e-3) to a Borrelia burgdorferi gene.Top Blast Hits: Updated monthly Click here to view the entire PsiBlast results. gi|42526106|ref|NP_971204.1| acetyl-CoA carboxylase, carbox... 528 e-148 gi|148381533|ref|YP_001256074.1| acetyl-coenzyme A carboxyl... 273 7e-72 gi|153938006|ref|YP_001392950.1| acetyl-CoA carboxylase, ca... 266 8e-70 gi|118443895|ref|YP_877027.1| acetyl-CoA carboxylase, carbo... 259 1e-67 gi|15896803|ref|NP_350152.1| Acetyl-CoA carboxylase beta su... 259 2e-67 gi|153852699|ref|ZP_01994136.1| hypothetical protein DORLON... 258 4e-67 gi|78044562|ref|YP_359986.1| acetyl-CoA carboxylase, carbox... 256 7e-67 gi|153952764|ref|YP_001393529.1| AccD [Clostridium kluyveri... 256 8e-67 gi|110601615|ref|ZP_01389793.1| acetyl-CoA carboxylase, car... 256 9e-67 gi|148265305|ref|YP_001232011.1| acetyl-CoA carboxylase, ca... 253 8e-66COGS Summary: COGS Search BeTs to clades of COG0777 COG name: Acetyl-CoA carboxylase beta subunit Functional Class:� I The phylogenetic pattern of COG0777 is ao--k-yqvdrlbcefghsnujxi-- Number of proteins in this genome belonging to this COG isBlocks Summary: Blocks Search Significant hit ( 4.7e-52) to 5/5 blocks of the PR01070 family, which is described as "Acetyl-CoA carboxylase carboxyl transferase beta subunit signature". Prints database entry for PR01070. PR01070A 100-114 1.1e-12 PR01070B 134-152 9.3e-15 PR01070C 171-188 5.6e-13 PR01070D 200-211 3.7e-05 PR01070E 222-231 2.8ProDom Summary: Protein Domain Search Residues 171 to 247 match (2e-24) PD:PD003130 which is described as BETA TRANSFERASE SUBUNIT CARBOXYLASE PROTEOME COMPLETE CARBOXYL A ACETYL-COENZYME LIGASE Residues 98 to 166 match (2e-17) PD:PD001571 which is described as BETA TRANSFERASE SUBUNIT CARBOXYLASE COMPLETE PROTEOME CARBOXYL ACETYL-COENZYME A LIGASE Residues 21 to 97 match (3e-09) PD:PD003279 which is described as BETA SUBUNIT CARBOXYLASE TRANSFERASE COMPLETE PROTEOME LIGASE CARBOXYL CHAIN A Residues 34 to 187 match (4e-07) PD:PD003448 which is described as SUBUNIT DECARBOXYLASE MALONATE BETA CARRIER PROTEOME BIOTIN PROTEIN: PLASMID COMPLETE Residues 162 to 231 match (8e-07) PD:PD312146 which is described as CARBOXYLASE PYRUVATE CARBOXYLASE/PYRUVATE ACETYL-COA FUSIONParalogs: Local Blast Search TDE0590 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.Pfam Summary: Pfam SearchTop PDB Hits: PDB hits to TDE0590 from Psi-BLAST round 5 vs. nr database 21.8% similar to PDB:1ON3 Transcarboxylase 12s Crystal Structure: Hexamer Assembly And Substrate Binding T (Chain A,B,C,D,E,F; 2e-50) 21.8% similar to PDB:1ON9 Transcarboxylase 12s Crystal Structure: Hexamer Assembly And Substrate Binding T (Chain A,B,C,D,E,F; 2e-50)Gene Protein Sequence: MDCPSCKVSYDEEVFTDNLMVCPHCNCHLRIEPRQRITYLTDENSFQELY PNLKTCNPIEMEGYEEKISAAEEKASLNEAVITGSCKIKGRDALLALMSF HFMGGSMGSVVGEKISRLMLKGATERIPVIIYATSGGARMQEGLFSLMQM AKTSSAAAELDEKGVPLFIMLCDPTTGGVTASFAMLGDITAAEPGALIGF AGPRVIEGTIRQQLPEGFQRAEFQLEKGFVDCIVPRQEQRQFFARMIDAH SLGLKETPKKKKAGene Nucleotide Sequence: Sequence Viewer ATGGATTGTCCTAGTTGTAAAGTATCATACGATGAAGAGGTTTTTACAGA TAACCTGATGGTTTGTCCTCATTGCAATTGCCATTTACGCATAGAACCGA GGCAGAGGATTACCTATCTGACCGATGAAAATTCGTTTCAAGAGCTGTAT CCGAACCTCAAAACATGTAACCCCATCGAAATGGAAGGTTATGAAGAAAA GATTTCGGCTGCTGAAGAAAAAGCGTCCTTAAACGAAGCCGTTATTACAG GTTCTTGTAAGATTAAAGGAAGAGATGCCCTCTTAGCCCTCATGTCCTTT CACTTTATGGGAGGTTCTATGGGCTCCGTTGTAGGCGAAAAGATTTCGCG GCTTATGCTAAAGGGAGCAACCGAAAGGATACCTGTAATTATCTATGCGA CTTCAGGCGGAGCACGAATGCAGGAAGGGCTTTTTTCGCTGATGCAGATG GCCAAAACTTCGAGTGCGGCTGCCGAGTTGGATGAAAAAGGAGTTCCTCT TTTTATAATGCTATGCGACCCTACCACGGGAGGTGTTACGGCAAGTTTTG CAATGCTTGGCGATATAACGGCAGCGGAACCGGGAGCCCTTATTGGATTT GCAGGCCCTAGAGTTATCGAAGGCACCATCCGCCAGCAGCTGCCAGAAGG ATTTCAGCGGGCGGAATTTCAGTTGGAAAAAGGCTTTGTGGACTGTATAG TGCCGCGCCAAGAGCAAAGGCAGTTTTTTGCCCGCATGATTGACGCTCAC AGCCTCGGCCTTAAAGAAACCCCTAAAAAGAAAAAGGCC

Los Alamos National Laboratory • Est 1943