Isoprenylcysteine carboxyl methyltransferase (ICMT)

EST Profile:

Approximate expression patterns inferred from EST sources.

Found only in library 17102: LIB4215

Found only in libraries from skeletal

cDNA Sources:

NCBI

UniGene
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Finding cDNAs

UGID:2677384 UniGene Cfa.42583 Canis lupus familiaris (dog) ICMT

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Isoprenylcysteine carboxyl methyltransferase (ICMT)

SELECTED PROTEIN SIMILARITIES

Comparison of sequences in UniGene with selected protein reference sequences. The alignments can suggest function of a gene.

Reference Protein		Species	Id(%)	Len(aa)
XP_546748.1	PREDICTED: similar to Protein-S-isoprenylcysteine O-methyltransferase (Isoprenylcysteine carboxylmethyltransferase) (Prenylcysteine carboxyl methyltransferase) (pcCMT) (Prenylated protein carboxyl methyltransferase) (PPMT) isoform 1	C. lupus familiaris	100.0	283
NP_598549.1	isoprenylcysteine carboxyl methyltransferase	M. musculus	97.5	283
NP_036537.1	isoprenylcysteine carboxyl methyltransferase	H. sapiens	97.5	283
NP_001081219.1	farnesyl cysteine carboxyl methyltransferase	X. laevis	76.3	279
NP_001017618.1	isoprenylcysteine carboxyl methyltransferase	D. rerio	66.7	282
NP_648623.1	CG11268 CG11268-PA	D. melanogaster	51.2	280
NP_568191.1	ATSTE14B (PRENYLCYSTEINE ALPHA-CARBOXYL METHYLTRANSFERASE); protein-S-isoprenylcysteine O-methyltransferase	A. thaliana	50.5	192
XP_001689935.1	predicted protein	C. reinhardtii	49.0	155
NP_010698.1	Farnesyl cysteine-carboxyl methyltransferase, mediates the carboxyl methylation step during C-terminal CAAX motif processing of a-factor and RAS proteins in the endoplasmic reticulum, localizes to the ER membrane; Ste14p	S. cerevisiae	45.3	222

GENE EXPRESSION

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.

SEQUENCES

Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

Model sequences (3)

XM_546748.2	PREDICTED: Canis familiaris similar to isoprenylcysteine carboxyl methyltransferase, transcript variant 1 (LOC489628), mRNA	P
XM_853507.1	PREDICTED: Canis familiaris similar to isoprenylcysteine carboxyl methyltransferase, transcript variant 3 (LOC489628), mRNA	P
XM_853461.1	PREDICTED: Canis familiaris similar to isoprenylcysteine carboxyl methyltransferase, transcript variant 2 (LOC489628), mRNA	P

EST sequences (1)

DN418016.1

Clone CLN10727078

muscle

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria