PUMA2: 3.1.2.15

		PUMA2 -- Evolutionary Analysis of Metabolism

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EC-number: 3.1.2.15 ----- ubiquitin thiolesterase

EC-NUMBER	3.1.2.15
ENZYME-NAME	ubiquitin thiolesterase
ENZYME-SYSNAME	Acts on esters formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin. Also acts on AMP-ubiquitin. May be the same as EC 3.4.19.12, ubiquitinyl hydrolase 1.
ENZYME-CLASS	Hydrolases Acting on ester bonds Thioester hydrolases
SYNONYMS	isopeptidase T;; isopeptidase;; ubiquitin C-terminal hydrolase;; ubiquitin carboxy-terminal esterase;; >>more synonyms
REACTION	ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol [RN:R02418]
PATHWAY	EMP-PATHWAYS: Ubiquitin-C-terminal-thiolester--Ubiquitin,_Thiol_Catabolism; >>more EMP pathways
	KEGG-PATHWAYS: NO KEGG PATHWAY FOUND
GO_TERM	GO:0004221:ubiquitin thiolesterase activity
ENZYME-COMMENT	ubiquitin-C-terminal-thioester hydrolase

ExternalDB ----- DBLINKS

Diseases

Structure

Gene

Motif

Ortholog

Literature

Other

InterPro Domains found in sequences annotated as EC 3.1.2.15
	IPR000194	H+-transporting two-sector ATPase, alpha/beta subunit, central region
	IPR000195	RabGAP/TBC
	IPR000354	Involucrin repeat
	IPR000408	Regulator of chromosome condensation, RCC1
	IPR000449	Ubiquitin-associated
	IPR000555	Mov34/MPN/PAD-1
	IPR000626	Ubiquitin
	IPR000938	CAP-Gly
	IPR001125	Recoverin
	IPR001360	Glycoside hydrolase, family 1
	IPR001394	Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2
	IPR001448	Small acid-soluble spore protein, alpha/beta type
	IPR001464	Annexin
	IPR001578	Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1
	IPR001607	Zinc finger, UBP-type
	IPR001763	Rhodanese-like
	IPR001876	Zinc finger, RanBP2-type
	IPR002048	Calcium-binding EF-hand
	IPR002083	MATH
	IPR002453	Beta tubulin
	IPR002893	Zinc finger, MYND-type
	IPR003006	Immunoglobulin/major histocompatibility complex
	IPR003903	Ubiquitin interacting motif
	IPR004274	NLI interacting factor
	IPR005479	Carbamoyl-phosphate synthase L chain, ATP-binding
	IPR006615	Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1
	IPR008957	Fibronectin, type III-like fold
	IPR008974	TRAF-like
	IPR008978	HSP20-like chaperone
	IPR009060	UBA-like
	IPR009818	Ataxin-2, C-terminal
	IPR010460	Ubiquitin carboxyl-terminal hydrolase, N-terminal region 2
	IPR011943	HAD-superfamily subfamily IIID hydrolase
	IPR011989	Armadillo-like helical
	IPR011990	Tetratricopeptide-like helical
	IPR011992	EF-Hand type
	IPR013322	TRAF-type

PIR SuperFamilies containing EC 3.1.2.15
SF005896	deubiquinating enzyme SSV7
SF009387	human ubiquitin thiolesterase
SF016308	ubiquitin-specific protease (ubiquitin carboxyl-terminal hydrolase)
SF016322	Ubiquitin carboxyl-terminal hydrolase
SF017491	ubiquitin thiolesterase Ubp2p
SF017639	ubiquitin carboxyl-terminal hydrolase
SF018230	ubiquitin thiolesterase, UBP9 type
SF022928	Saccharomyces cerevisiae probable membrane protein YPL072w
SF026975	Not Yet Assigned
SF036433	ubiquitin C-terminal hydrolase Ubp12

Taxonomic breakdown of EC 3.1.2.15 sequences

To perform phylogenetic analysis, first select some protein ids by clicking on their checkboxes, then click on one of the buttons below.

Additional gi numbers: