EDRI Federal Project Inventory:
00184-02 Prediagnostic Breast Cancer Serum Bank
- Sponsor Organization: NIH/CN
- Project Title: 00184-02 PREDIAGNOSTIC BREAST CANCER SERUM BANK
- Project Focus: HUMAN HEALTH EFFECTS
- Description: A major obstacle to our understanding of the etiology of breast cancer
is the lack of studies with prediagnostic serumfor analysis. This
year, the Cancer Prevention Studies Branch assumed responsibility for
the Columbia, Missouricollection of the Breast Cancer Serum Bank from
the Division of Cancer Biology, Diagnosis, and Centers, NCI.
Thiscollection includes serum collected between 1977 and 1987 from
7,641 women, 112 of whom subsequently developedbreast cancer.
Questionnaires on reproductive history, use of exogenous estrogens and
other medications, and cancerdiagnoses and treatment were completed
at each blood drawing. We currently are evaluating estrogen and
androgenlevels in serum from 74 women who developed postmenopausal
breast cancer and 148 matched controls. A study toevaluate pesticide
and PCB levels in serum from cases and noncases is being developed and
a study to analyzeantioxidants is planned. Analyses of serum from the
Breast Cancer Serum Bank will improve our understanding of therole of
diet and hormones, as well as environmental exposures, in the
etiology of breast cancer.
- References:
- Category: MEASUREMENTS
- Subcategory: BASIC RESEARCH
- Keywords for Experimental System/Species: HUMAN
- Keywords for Experimental Endpoints: HORMONE RECEPTORS, EXPOSURE MONITORING, CARCINOGENESIS
- Chemical Agents: NCI INTRAMURAL PROGRAM
- Performing Institution: PERFORMING INSTITUTION:
- Contact: ELAINE C. LEE; BUILDING 31; 11A21, NATIONAL CANCER INSTITUTE,
NIH,BETHESDA, MD 20892-2590; 301- 496-5515; LEEE@OD.NCI.NIH.GOV
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