Nelson AM, Okonda L, Mukadi Y, Moran C, Mbuyamba L, Kabongo B, Brown C, Mullick F; International Conference on AIDS.
Int Conf AIDS. 1991 Jun 16-21; 7: 247 (abstract no. W.B.2260).
Project SIDA, Kinshasa, Zaire
OBJECTIVE: To describe the histologic patterns of tuberculosis associated with clinical and immunologic stages of HIV infection in Zaire. METHODS: Biopsy and autopsy specimens from HIV-1 seropositive patients with a histologic pattern consistent with tuberculosis and presence of acid fast bacilli (AFB) on the tissue were evaluated for the following: pattern of lesions, type of necrosis (caseating (CN) vs. suppurative (SN)), number of Langhans giant cells (LGH), granuloma formation and number of AFB. Histologic findings were correlated with WHO clinical stage and, if available, T-cell phenotyping, interdermal reaction (PPD, candida) and treatment history. RESULTS: Preliminary results from 20 biopsies and 25 autopsies showed the following: TABULAR DATA, SEE ABSTRACT VOLUME. Histologic evidence of impaired cellular immune reaction and large numbers of AFB correlated with low %T4 and cutaneous anergy. Treatment did not affect findings in stage 4 disease. CONCLUSIONS: Tuberculosis in this population of HIV-1 infected Zairians is associated with histologic and clinical evidence of progressive loss of cellular immune reaction. Anergic and miliary tuberculosis were the most common forms seen in WHO Clinical Stage 4 disease.
Publication Types:
Keywords:
- Democratic Republic of the Congo
- Granuloma
- HIV Infections
- HIV-1
- Humans
- Tuberculin Test
- Tuberculosis
- Tuberculosis, Miliary
- anatomy & histology
Other ID:
UI: 102192864
From Meeting Abstracts