Main kinase page
tyrosine kinases
tk tree
tk tree with Pfam domains included
tk alignment (warning!! insertions are deleted)
Additional domains and groups (E.lt.10)(classification is based on catalytic domain only, and subgroups are sometimes
quite arbitrary, see tree in pdf format, above, and groupings, listed below)
Pfam links :
SH2
SH3
Ephrin_lbd
fn3
Furin-like
ig
Recep_L_domain
SAM
Focal_AT
Kringle
F5_F8_type_C
BTK
PH
Fz
Sema
TIG
PSI
EGF
WIF
FCH
Cadherin
pdb links
group A -- CSK (1k9a)
(1byg)
BTK (1k2p)
ABL (1opl)
(1opk)
(1fpu)
(1iep)
(1m52)
(1opj)
HCK (1ad5)
(2hck)
(1qcf)
LCK (1qpd)
1qpc(ANP)
(1qpe)
(1qpj)
3lck(*)
SRC (1ksw)
(1fmk)
(2src)
(2ptk)
group B -- Igf1 1k3a(ACP,S)
(1p4o)
(1m7n)
(1jqh)
IRK (1rqq)
(1gag)
(1ir3)
(1p14)
(1i44)
(1irk)
MuSK 1luf()
c-MET 1r0p()
1r1w()
group C -- TIE2 (1fvr)
c-KIT (1pkg)
VEGFR (1vr2)
FGFR2 (1gjo)
FGFR1 (1agw)
(1fgi)
(1fgk)
(2fgi)
group D -- Focal Adhesion Kinase (FAK) (1mp8)
EGFR (1m14)
(1m17)
group E -- Eph A2 1mqb()
Eph B2 1jpa()
Phospho.ELM links:
ABL (A);
CSK (A);
BTK (A);
ITK (A);
LCK (A);
HCK (A);
LYN (A);
FYN (A);
SRC (A);
YES (A);
TRKA (B);
TRKB (B);
IGF1R (B);
IRR (B);
ALK (B);
MER (B);
MET (B);
RON (B);
FGFR1 (C);
FGFR2 (C);
FGFR3 (C);
FGFR4 (C);
FLT x (C);
FLT x (C);
KIT (C);
PDGFRa (C);
PDGFRb (C);
TIE (C);
EGFR (D);
HER2-ErbB2 ();
TYK2 (D);
JAK1 (D);
JAKx (D);
JAK2 (D);
JAK3 (D);
FAK (D);
SYK (D);
ZAP70 (D);
EphB1 (E);
EphB2 (E);
EphB3 (E);
EphA3 (E);
EphA (E);
EphA8 (E);
FER (F);
FES (F);
group A - (BRK SRM FRK FGR FYN YES SRC BLK HCK LYN LCK ACK TNK1 BTK BMX TEC TXK ITK ABL ARG CSK CTK)
group B - (ALK LTK ROS INSR IGF1R IRR AXL MER TYRO3 MET RON RYK MUSK TRKA TRKB TRKC DDR1 DDR2 ROR1 ROR2 LMR1 LMR2 LMR3 CCK4)
group C - (RET SuRTK106 KDR FLT4 FLT1 FMS KIT FLT3 PDGFRa PDGFRb FGFR1 FGFR2 FGFR3 FGFR4 TIE1 TIE2)
group D - (EGFR ZAP70 SYK JAK1 TYK2 FAK2 JAK3 FAK PYK2)
group E - (EPHA1 EPHA2 EPHA3 EPHA4 EPHA5 EPHA6 EPHA7 EPHA8 EPHA10 EPHB1 EPHB2 EPHB3 EPHB4 EPHB6 )
group F - (FER FES)
Sequence entropy, over all 5915 protein kinases (red) and 506 tk kinases (green)
Residues which distinguish TK from other kinases (INSR.h as reference): R160 E256 A261 G103 F388 K177 E97 G82 R218 W370
residues in order of increasing entropy
380 154 256 223 160 34 251 246 182 10 141 177 61 248 161 155 145 158 219 97 157 156 105 163 250 180 33 103 181 252 162 142 261 15 178 13 8 245 18 144 74 221 109 249 138 77 247 264 183 82
covariation analysis
crystal structure of IRK (1ir3.pdb) with residues numbered according to alignment
residues in order of decreasing number of covariation partners
279 133 66 239 140 263 260 226 213 14 186 371 212 63 208 227 266 112 28 354 128 188 268 187 362 6 175 269 146 394 209 67 85 79 372 174 22 358 16 81 4 214 114 89 115 370 35 41 39 53
list of covariation partners, INSR.human sequence as reference
INSR residue,number (entropy) -- covariation partners
I1 (2.47) covaries with -- 3 78
T2 (3.83) covaries with -- 3 12 22 29 39 83 120 127 185 224 266 267 275 351 364
L3 (3.53) covaries with -- 1 2 52 85 148 209 238
L4 (3.80) covaries with -- 5 6 19 22 23 24 53 54 60 88 107 113 135 174 204 206 226 227 262 268 279 372 394
R5 (3.49) covaries with -- 4 11 27 389 391 394
E6 (3.65) covaries with -- 4 11 14 16 19 41 60 63 66 80 89 90 92 101 111 115 133 136 140 174 187 212 226 390 392 394
L7 (1.85) covaries with -- 8 12 13 15 90
G8 (1.63) covaries with -- 7 10 12 13 15 32 107 163 180 181 182 208 372
Q9 (3.47) covaries with -- 14 30 52 66 104 129 211 212
G10 (0.93) covaries with -- 8 175 210 268
S11 (3.38) covaries with -- 5 6 28 32 51 53 59 60 61 79 89 107 165 179 217 220 266 281
F12 (1.88) covaries with -- 2 7 8 13 15 180
G13 (1.62) covaries with -- 7 8 12 28
M14 (3.53) covaries with -- 6 9 16 19 21 28 29 35 37 60 63 67 69 79 83 91 112 114 115 128 140 146 186 209 220 238 239 263 353 357 360 376 379
V15 (1.59) covaries with -- 7 8 12 32 151
Y16 (3.47) covaries with -- 6 14 18 21 22 23 28 35 38 53 56 81 114 120 133 186 187 212 243 274 279 371 392
E17 (3.26) covaries with -- 30 63 112 128 129 179 259
G18 (1.65) covaries with -- 16 264
N19 (3.83) covaries with -- 4 6 14 22 27 28 29 30 38 41 54 55 63 115 146 204 210 268 368 372
A20 (2.95) covaries with -- 23 28 29 81 133 203 227 240 267 281
R21 (3.86) covaries with -- 14 16 26 28 59 66 85 93 100 128 175 243 267 268
D22 (3.89) covaries with -- 2 4 16 19 23 35 38 63 66 81 93 101 113 135 166 185 215 220 259 260 263 356 371 395
I23 (3.92) covaries with -- 4 16 20 22 30 63 66 81 88 107 129 227 267 282 367
k24 (3.71) covaries with -- 4 27 38 113 140 174
g25 (3.86) covaries with -- 28 39 79 89 158 176 360
E26 (3.77) covaries with -- 21 27 28 30 39 66 100 115 133 220 267 368
A27 (3.79) covaries with -- 5 19 24 26 29 39 41 128 133 209 262
E28 (4.07) covaries with -- 11 13 14 16 19 20 21 25 26 29 38 41 53 55 63 66 76 81 100 112 114 115 128 133 204 212 282 354 376
T29 (3.72) covaries with -- 2 14 19 20 27 28 55 81 88 128 133 368 394
R30 (3.87) covaries with -- 9 17 19 23 26 54 59 60 67 99 106 132 206 210 212 226 266 361
V31 (1.92) covaries with --
A32 (1.85) covaries with -- 8 11 15 39 61 64 65 155 163 180 181 182 208 210 214 239 368
V33 (1.42) covaries with --
K34 (0.62) covaries with -- 156 161 180
T35 (3.32) covaries with -- 14 16 22 40 41 42 62 67 69 85 130 134 166 186 187 210 224 239 357 360 371
V36 (2.85) covaries with -- 42 58 60 151 359 391
N37 (3.44) covaries with -- 14
E38 (3.78) covaries with -- 16 19 22 24 28 40 41 89 91 100 110 111 128 133 187 204 209 243 260
S39 (3.84) covaries with -- 2 25 26 27 32 41 42 60 64 78 79 83 85 111 114 133 151 155 166 175 356
A40 (3.71) covaries with -- 35 38 41 84 89 105 111 174 205 211 212 213 260 357 360
S41 (3.76) covaries with -- 6 19 27 28 35 38 39 40 42 60 81 211 212 213 220 227 239 260 269 357 371
L42 (3.80) covaries with -- 35 36 39 41 60 66 88 111 115 212 213 243 263 368 371 376 378
-43 (3.57) covaries with -- 54
-44 (0.00) covaries with --
-45 (0.00) covaries with --
-46 (0.00) covaries with --
-47 (0.00) covaries with --
-48 (0.00) covaries with --
-49 (1.00) covaries with --
-50 (1.58) covaries with --
-51 (3.17) covaries with -- 11 64 92 188 202 350 361
-52 (3.74) covaries with -- 3 9 56 166 382 389 390
R53 (3.81) covaries with -- 4 11 16 28 63 65 66 84 86 89 96 112 148 208 214 226 266 279 356 361 368
E54 (3.49) covaries with -- 4 19 30 43 59 87 90 111 140 157 175 184 186 217 260 354 393
R55 (3.77) covaries with -- 19 28 29 57 99 101 111 112 127 148 226 269 273 277 280 348 372 392 393 394
I56 (3.85) covaries with -- 16 52 63 90 101 114 116 131 166 204 205 208 213 274 360 372
E57 (3.29) covaries with -- 55 58 62 78 79 100 107 151 181 187 207 214 238 368 372
F58 (2.35) covaries with -- 36 57 140 165 239
L59 (3.32) covaries with -- 11 21 30 54 65 79 85 115 243 269 376
N60 (3.50) covaries with -- 4 6 11 14 30 36 39 41 42 77 79 96 146 147 204 226 245 262 263 352
E61 (1.08) covaries with -- 11 32 65 144 146 148 155 180 181 208 214
A62 (2.63) covaries with -- 35 57 67 69 79 83 140 162 273 277
S63 (3.62) covaries with -- 6 14 17 19 22 23 28 53 56 66 85 89 90 92 97 101 111 127 138 143 167 204 208 209 210 211 213 238 260 262 282
V64 (3.09) covaries with -- 32 39 51 65 85 100 107 155 240 356
M65 (2.20) covaries with -- 32 53 59 61 64 85 155
K66 (3.28) covaries with -- 6 9 21 22 23 26 28 42 53 63 85 90 96 99 128 129 131 133 134 135 140 148 155 166 167 175 177 181 186 188 206 209 211 215 220 226 260 263 266 269 277 357 372 394
G67 (3.67) covaries with -- 14 30 35 62 75 79 83 92 107 115 116 135 146 163 165 226 268 276 277 279 281 354 357 364 394
F68 (2.34) covaries with -- 69
T69 (3.36) covaries with -- 14 35 62 68 79 83 133 136 144 148 151 162 209 217 262 263 268 372 376 393
-70 (3.23) covaries with -- 279
-71 (0.00) covaries with --
-72 (0.00) covaries with --
-73 (2.58) covaries with --
C74 (1.68) covaries with -- 76
H75 (3.44) covaries with -- 67 77 79 210 226
H76 (2.38) covaries with -- 28 74 77 140 202
V77 (1.73) covaries with -- 60 75 76 79 80 82 106
V78 (2.12) covaries with -- 1 39 57 88 89 279
R79 (3.31) covaries with -- 11 14 25 39 57 59 60 62 67 69 75 77 80 81 82 83 101 114 116 134 135 269 357 391
L80 (2.63) covaries with -- 6 77 79 81 82 92 142 179
L81 (2.80) covaries with -- 16 20 22 23 28 29 41 79 80 82 104 113 146 148 206 215 226 260 263 265 268 279 348
G82 (1.81) covaries with -- 77 79 80 81 85 107
V83 (2.81) covaries with -- 2 14 39 62 67 69 79 85 99 115 133 140 146 214 239 263 269 273 280 281
V84 (2.70) covaries with -- 40 53 88 239 254 274 281 370
S85 (3.43) covaries with -- 3 21 35 39 59 63 64 65 66 82 83 88 91 99 116 140 142 146 174 209 212 266 273 376
-86 (3.69) covaries with -- 53 175 188
-87 (3.79) covaries with -- 54
K88 (3.79) covaries with -- 4 23 29 42 78 84 85 91 94 108 112 113 120 133 209 212 263 266 278 350
G89 (3.75) covaries with -- 6 11 25 38 40 53 63 78 91 92 93 98 110 111 126 136 174 186 187 263 278 394
Q90 (3.81) covaries with -- 6 7 54 56 63 66 98 112 115 122 129 136 186
P91 (3.33) covaries with -- 14 38 85 88 89 111 165 177 207
T92 (3.38) covaries with -- 6 51 63 67 80 89 95 112 166 239
L93 (3.19) covaries with -- 21 22 89 97 99 266 379
V94 (2.14) covaries with -- 88 132 188
V95 (2.11) covaries with -- 92 96 112
M96 (2.82) covaries with -- 53 60 66 95 97 98 99 105 140 188 213 268 349
E97 (1.29) covaries with -- 63 93 96 99 182 277
L98 (2.39) covaries with -- 89 90 96 103 146
M99 (2.69) covaries with -- 30 55 66 83 85 93 96 97 101 103 134 140 152 182 187 212 239 267
A100 (3.74) covaries with -- 21 26 28 38 57 64 101 107 112 133 166 167 175 187 228 262 279
H101 (3.59) covaries with -- 6 22 55 56 63 79 99 100 102 112 134 146 164 214 257
-102 (3.31) covaries with -- 101
G103 (1.43) covaries with -- 98 99 252
D104 (2.55) covaries with -- 9 81 106 135 174 175 188 215 260 263 279 281 350
L105 (1.38) covaries with -- 40 96 257
K106 (3.07) covaries with -- 30 77 104 110 135 188 212 261
S107 (3.50) covaries with -- 4 8 11 23 57 64 67 82 100 208 362 368
Y108 (2.54) covaries with -- 88 112 113 132 184 213 266
L109 (1.69) covaries with -- 116
R110 (3.27) covaries with -- 38 89 106 120 165 261 269
S111 (3.71) covaries with -- 6 38 39 40 42 54 55 63 89 91 112 117 208 212
L112 (3.73) covaries with -- 14 17 28 53 55 88 90 92 95 100 101 108 111 113 114 115 116 120 127 145 147 153 213 239 247 278 353 376 393
R113 (3.54) covaries with -- 4 22 24 81 88 108 112 129 140 175 227 239 260 279 353 361
P114 (3.85) covaries with -- 14 16 28 39 56 79 112 115 133 188 204 206 208 209 212 214 227 263 274 372 393 394
E115 (4.01) covaries with -- 6 14 19 26 28 42 59 67 83 90 112 114 128 140 146 175 204 212 238 263 353 389
A116 (3.94) covaries with -- 56 67 79 85 109 112 128 129 133 166 243 263 278 356 357 367
E117 (4.13) covaries with -- 111 123 140 275
N118 (4.17) covaries with -- 120
N119 (4.03) covaries with --
P120 (4.13) covaries with -- 2 16 88 110 112 118 122 129 239
g121 (4.09) covaries with --
r122 (4.15) covaries with -- 90 120
p123 (3.97) covaries with -- 117 125
p124 (4.08) covaries with --
-125 (4.00) covaries with -- 123
P126 (2.78) covaries with -- 89 220 228
T127 (3.59) covaries with -- 2 55 63 112 130
L128 (3.93) covaries with -- 14 17 21 27 28 29 38 66 115 116 129 130 133 136 147 174 186 204 211 226 239 267 273 274 282 360 361 377
Q129 (3.90) covaries with -- 9 17 23 66 90 113 116 120 128 136 239 263 277 279 356 358
E130 (3.54) covaries with -- 35 127 128 133 136 140 174 226
M131 (2.58) covaries with -- 56 66 135 138 213 257 260 363 371
I132 (3.11) covaries with -- 30 94 108 140 209 213 218 224 362
Q133 (3.86) covaries with -- 6 16 20 26 27 28 29 38 39 66 69 83 88 100 114 116 128 130 134 136 138 146 165 166 174 202 208 209 212 226 227 243 254 263 269 277 283 357 364 367 371 372 392 393
M134 (2.60) covaries with -- 35 66 79 99 101 133 136 140 226 268 361 364
A135 (2.86) covaries with -- 4 22 66 67 79 104 106 131 142 146 165 174 208 254 257 279 356 371
A136 (3.84) covaries with -- 6 69 89 90 128 129 130 133 134 140 165 243 274 279 350 361 378 390 392
E137 (2.03) covaries with -- 162 186 187 212 257 263 354 363
I138 (1.70) covaries with -- 63 131 133 142 157 176 249 253 254 259 260 362 363 366 369 370 381
A139 (2.08) covaries with -- 372 394
D140 (3.60) covaries with -- 6 14 24 54 58 62 66 76 83 85 96 99 113 115 117 130 132 134 136 143 148 167 174 175 176 186 202 210 218 220 226 239 257 260 262 269 365 372 376 392
G141 (0.98) covaries with -- 178 208
M142 (1.51) covaries with -- 80 85 135 138 146 157 362 388
A143 (3.42) covaries with -- 63 140 262 356 382 392 394
Y144 (1.66) covaries with -- 61 69 148 181
L145 (1.17) covaries with -- 112 260 352 362
N146 (2.73) covaries with -- 14 19 60 61 67 81 83 85 98 101 115 133 135 142 204 214 226 227 239 243 273 274 275 372 388
A147 (3.34) covaries with -- 60 112 128 351 389 398
K148 (3.42) covaries with -- 3 53 55 61 66 69 81 140 144 151 174 214 279 368
-149 (1.58) covaries with --
-150 (1.58) covaries with --
K151 (3.25) covaries with -- 15 36 39 57 69 148 186 202 239 279
F152 (2.65) covaries with -- 99 174 177 179 188 212 215 227 240 366 370
V153 (1.93) covaries with -- 112 164 260
H154 (0.29) covaries with --
R155 (1.15) covaries with -- 32 39 61 64 65 66 179 181 214 239 240
D156 (1.30) covaries with -- 34 158 161 180 183 215 216
L157 (1.29) covaries with -- 54 138 142 164 243
A158 (1.22) covaries with -- 25 156 160 161 215 216
A159 (2.06) covaries with -- 163 187
R160 (0.57) covaries with -- 158 240
N161 (1.15) covaries with -- 34 156 158 180 183 215 216 217
C162 (1.50) covaries with -- 62 69 137 173 249 265 381 388
M163 (1.38) covaries with -- 8 32 67 159 181 182 277
V164 (1.84) covaries with -- 101 153 157 239
A165 (3.19) covaries with -- 11 58 67 91 110 133 135 136 175 227 257 266 273 394
H166 (3.51) covaries with -- 22 35 39 52 56 66 92 100 116 133 167 187 205 243 262 266 275 279
D167 (3.63) covaries with -- 63 66 100 140 166 175 263 266 268 356
-168 (3.31) covaries with --
-169 (2.99) covaries with --
-170 (3.40) covaries with -- 173 394
-171 (2.69) covaries with --
-172 (3.20) covaries with --
-173 (3.53) covaries with -- 162 170
F174 (3.53) covaries with -- 4 6 24 40 85 89 104 128 130 133 135 140 148 152 175 202 227 263 268 277 279 350 372 393
T175 (3.53) covaries with -- 10 21 39 54 66 86 100 104 113 115 140 165 167 174 188 209 213 215 254 266 273 368 370 371 381
V176 (2.42) covaries with -- 25 138 140 188
K177 (1.03) covaries with -- 66 91 152
I178 (1.61) covaries with -- 141 239
G179 (2.13) covaries with -- 11 17 80 152 155 181
D180 (1.41) covaries with -- 8 12 32 34 61 156 161 181 208
F181 (1.46) covaries with -- 8 32 57 61 66 144 155 163 179 180 182 213 214 239 356
G182 (0.86) covaries with -- 8 32 97 99 163 181 356
M183 (1.75) covaries with -- 156 161 184 185
T184 (2.41) covaries with -- 54 108 183 239
R185 (2.70) covaries with -- 2 22 183 187 213 224 239 352 358 362 370
D186 (3.83) covaries with -- 14 16 35 54 66 89 90 128 137 140 151 187 188 204 208 209 210 211 212 214 215 220 224 226 227 243 253 255 260 263 279 353 356
I187 (3.46) covaries with -- 6 16 35 38 57 89 99 100 137 159 166 185 186 188 213 226 228 238 239 243 259 263 266 281 354 358 370
Y188 (3.82) covaries with -- 51 66 86 94 96 104 106 114 152 175 176 186 187 203 204 206 208 209 212 227 243 263 269 279 353 364 394
-189 (2.76) covaries with --
-190 (0.00) covaries with --
-191 (0.00) covaries with --
-192 (1.00) covaries with --
-193 (1.00) covaries with --
-194 (2.58) covaries with --
-195 (2.32) covaries with --
-196 (2.32) covaries with --
-197 (1.97) covaries with --
-198 (2.32) covaries with --
-199 (2.58) covaries with --
-200 (2.80) covaries with -- 203
-201 (3.04) covaries with --
-202 (3.74) covaries with -- 51 76 133 140 151 174 204 279 350
E203 (3.74) covaries with -- 20 188 200 227 278
T204 (3.61) covaries with -- 4 19 28 38 56 60 63 114 115 128 146 186 188 202 207 208 210 226 372 376
D205 (3.36) covaries with -- 40 56 166 206 207 208
Y206 (3.68) covaries with -- 4 30 66 81 114 188 205 208 211 263 279 372 393 394
Y207 (3.41) covaries with -- 57 91 204 205 208 209 356
R208 (3.62) covaries with -- 8 32 53 56 61 63 107 111 114 133 135 141 180 186 188 204 205 206 207 209 210 212 213 226 263 277 279 371 372 379 394
K209 (3.71) covaries with -- 3 14 27 38 63 66 69 85 88 114 132 133 175 186 188 207 208 210 211 212 213 220 227 263 279
G210 (3.72) covaries with -- 10 19 30 32 35 63 75 140 186 204 208 209 213 214 243 254 260 266 281
G211 (3.75) covaries with -- 9 40 41 63 66 128 186 206 209 212 213 218 226 227 266 267 349 371
K212 (3.62) covaries with -- 6 9 16 28 30 40 41 42 85 88 99 106 111 114 115 133 137 152 186 188 208 209 211 214 227 228 263 266 268 269 279 371
G213 (3.56) covaries with -- 40 41 42 56 63 96 108 112 131 132 175 181 185 187 208 209 210 211 214 224 238 243 245 262 273 275 278 283 350 354 356 358 362 370
L214 (3.38) covaries with -- 32 53 57 61 83 101 114 146 148 155 181 186 210 212 213 220 226 227 240 244 268 274 350
L215 (3.04) covaries with -- 22 66 81 104 152 156 158 161 175 186 216 220 227 239 263
P216 (1.83) covaries with -- 156 158 161 215 217 219
V217 (2.69) covaries with -- 11 54 69 161 216 218 219 275
R218 (2.21) covaries with -- 132 140 211 217 253 263 265 266
W219 (1.24) covaries with -- 216 217 221 222 252
M220 (2.45) covaries with -- 11 14 22 26 41 66 126 140 186 209 214 215 224 239 240 260 263 266 279 350
A221 (1.69) covaries with -- 219
P222 (2.20) covaries with -- 219
E223 (0.44) covaries with --
S224 (2.55) covaries with -- 2 35 132 185 186 213 220 239 244 259 260 268 279 354 358 363 371 388
L225 (2.43) covaries with --
K226 (3.75) covaries with -- 4 6 30 53 55 60 66 67 75 81 128 130 133 134 140 146 186 187 204 208 211 214 227 238 240 269 278 281 356 357 358 361 372 394
D227 (3.52) covaries with -- 4 20 23 41 113 114 133 146 152 165 174 186 188 203 209 211 212 214 215 226 239 240 260 269 273 279 281 282 353 356
-228 (2.99) covaries with -- 100 126 187 212
-229 (1.98) covaries with --
-230 (0.97) covaries with --
-231 (0.00) covaries with --
-232 (1.58) covaries with --
-233 (1.00) covaries with --
-234 (0.00) covaries with --
-235 (1.00) covaries with --
-236 (1.00) covaries with --
-237 (3.00) covaries with --
G238 (3.57) covaries with -- 3 14 57 63 115 187 213 226 246 269 273 352 359 393
V239 (3.80) covaries with -- 14 32 35 41 58 83 84 92 99 112 113 120 128 129 140 146 151 155 164 178 181 184 185 187 215 220 224 227 240 243 260 263 266 278 352 353 358 363 371 388 397 398
F240 (3.17) covaries with -- 20 64 152 155 160 214 220 226 227 239 241 244 260 277
-241 (1.19) covaries with -- 240
T242 (1.87) covaries with -- 273
T243 (3.55) covaries with -- 16 21 38 42 59 116 133 136 146 157 166 186 187 188 210 213 239 358 362 388
S244 (3.00) covaries with -- 214 224 240 266 378 379
S245 (1.64) covaries with -- 60 213 250
D246 (0.76) covaries with -- 238 248 388
M247 (1.74) covaries with -- 112
W248 (1.12) covaries with -- 246 249 259 260 269 354 363 369 371 388
S249 (1.70) covaries with -- 138 162 248
F250 (1.40) covaries with -- 245 259 370 388
G251 (0.72) covaries with --
V252 (1.50) covaries with -- 103 219
V253 (2.22) covaries with -- 138 186 218 266
L254 (2.38) covaries with -- 84 133 135 138 175 210 371
W255 (1.95) covaries with -- 186 279
E256 (0.30) covaries with --
I257 (2.26) covaries with -- 101 105 131 135 137 140 165 266 268
T258 (3.02) covaries with -- 362
S259 (2.28) covaries with -- 17 22 138 187 224 248 250 260 262 280 352 354 355 358 362 366 371 388
L260 (3.03) covaries with -- 22 38 40 41 54 63 66 81 104 113 131 138 140 145 153 186 210 220 224 227 239 240 248 259 262 263 274 279 353 358 363 366 367 369 370 371 381
A261 (1.57) covaries with -- 106 110 264 265 267
E262 (3.70) covaries with -- 4 27 60 63 69 100 140 143 166 213 259 260 265 354 393
Q263 (3.64) covaries with -- 14 22 42 60 66 69 81 83 88 89 104 114 115 116 129 133 137 167 174 186 187 188 206 208 209 212 215 218 220 239 260 266 267 269 279 281 354
P264 (1.75) covaries with -- 18 261 265 267 268 269 279
Y265 (2.64) covaries with -- 81 162 218 261 262 264 266 267 268 279
Q266 (3.74) covaries with -- 2 11 30 53 66 85 88 93 108 165 166 167 175 187 210 211 212 218 220 239 244 253 257 263 265 267 268 279 393
G267 (3.52) covaries with -- 2 20 21 23 26 99 128 211 261 263 264 265 266 268 274 279 347 394
L268 (3.53) covaries with -- 4 10 19 21 67 69 81 96 134 167 174 212 214 224 257 264 265 266 267 269 279 280 281 350 356 372 396
S269 (3.73) covaries with -- 41 55 59 66 79 83 110 133 140 188 212 226 227 238 248 263 264 268 273 276 277 350 353 354 358
-270 (3.86) covaries with --
-271 (3.62) covaries with --
-272 (3.75) covaries with -- 350
N273 (3.73) covaries with -- 55 62 83 85 128 146 165 175 213 227 238 242 269 275 280 357
E274 (3.88) covaries with -- 16 56 84 114 128 136 146 214 260 267 279
Q275 (3.44) covaries with -- 2 117 146 166 213 217 273 276 277 282 283 351
V276 (2.74) covaries with -- 67 269 275 280
L277 (3.51) covaries with -- 55 62 66 67 97 129 133 163 174 208 240 269 275 279 354
K278 (3.84) covaries with -- 88 89 112 116 203 213 226 239 279 282
F279 (3.89) covaries with -- 4 16 53 67 70 78 81 100 104 113 129 135 136 148 151 166 174 186 188 202 206 208 209 212 220 224 227 255 260 263 264 265 266 267 268 274 277 278 283 350 351 354 363 368 370 371 381 394
V280 (2.63) covaries with -- 55 83 259 268 273 276 351
M281 (3.69) covaries with -- 11 20 67 83 84 104 187 210 226 227 263 268 282 283 350 356 372
D282 (3.63) covaries with -- 23 28 63 128 227 275 278 281 362 378 393
G283 (2.92) covaries with -- 133 213 275 279 281 362
G284 (2.86) covaries with --
-285 (1.58) covaries with --
-286 (0.00) covaries with --
-287 (0.00) covaries with --
-288 (0.00) covaries with --
-289 (0.00) covaries with --
-290 (0.00) covaries with --
-291 (0.00) covaries with --
-292 (0.00) covaries with --
-293 (0.00) covaries with --
-294 (0.00) covaries with --
-295 (0.00) covaries with --
-296 (0.00) covaries with --
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-347 (3.09) covaries with -- 267
-348 (3.31) covaries with -- 55 81
-349 (3.51) covaries with -- 96 211 350 351 352 354 362 379
-350 (3.67) covaries with -- 51 88 104 136 174 202 213 214 220 268 269 272 279 281 349 351 352 354 357 358 392
Y351 (3.07) covaries with -- 2 147 275 279 280 349 350 352 354 355 358 362 366 369 370 371
L352 (2.73) covaries with -- 60 145 185 238 239 259 349 350 351 353 354 355 358 362 363 366 370 381
D353 (3.67) covaries with -- 14 112 113 115 186 188 227 239 260 269 352 354 357 358 361 366 368 371
Q354 (3.56) covaries with -- 28 54 67 137 187 213 224 248 259 262 263 269 277 279 349 350 351 352 353 355 358 362 363 367 369 370 391 394
P355 (2.68) covaries with -- 259 351 352 354 356 358 362 363 366 370
D356 (3.75) covaries with -- 22 39 53 64 116 129 135 143 167 181 182 186 207 213 226 227 268 281 355 358 371
N357 (3.88) covaries with -- 14 35 40 41 66 67 79 116 133 226 273 350 353 358 360 362 364 366 368 372
C358 (2.99) covaries with -- 129 185 187 213 224 226 239 243 259 260 269 350 351 352 353 354 355 356 357 361 362 363 366 370
P359 (2.87) covaries with -- 36 238
E360 (3.89) covaries with -- 14 25 35 40 56 128 357 364 367 382 393
R361 (3.84) covaries with -- 30 51 53 113 128 134 136 226 353 358 362 363 366 394
V362 (2.91) covaries with -- 107 132 138 142 145 185 213 243 258 259 282 283 349 351 352 354 355 357 358 361 363 366 370 381 388 392
T363 (3.21) covaries with -- 131 137 138 224 239 248 260 279 352 354 355 358 361 362 366 367 370 381 388
D364 (3.87) covaries with -- 2 67 133 134 188 357 360 371 394
L365 (2.52) covaries with -- 140 369
M366 (2.42) covaries with -- 138 152 259 260 351 352 353 355 357 358 361 362 363 370 371 381
R367 (3.71) covaries with -- 23 116 133 260 354 360 363 368
M368 (3.81) covaries with -- 19 26 29 32 42 53 57 107 148 175 279 353 357 367 371 379
C369 (1.88) covaries with -- 138 248 260 351 354 365 370 371
W370 (2.03) covaries with -- 84 138 152 175 185 187 213 250 260 279 351 352 354 355 358 362 363 366 369 371 381
Q371 (3.64) covaries with -- 16 22 35 41 42 131 133 135 175 208 211 212 224 239 248 254 259 260 279 351 353 356 364 366 368 369 370 377 379 392 393 394
F372 (3.95) covaries with -- 4 8 19 55 56 57 66 69 114 133 139 140 146 174 204 206 208 226 268 281 357 376 392 394
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N376 (3.50) covaries with -- 14 28 42 59 69 85 112 140 204 372
P377 (2.83) covaries with -- 128 371 379
K378 (3.68) covaries with -- 42 136 244 282
M379 (3.64) covaries with -- 14 93 208 244 349 368 371 377
R380 (0.14) covaries with --
P381 (2.35) covaries with -- 138 162 175 260 279 352 362 363 366 370 391
T382 (3.27) covaries with -- 52 143 360
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F388 (1.95) covaries with -- 142 146 162 224 239 243 246 248 250 259 362 363 391
L389 (3.77) covaries with -- 5 52 115 147
E390 (3.69) covaries with -- 6 52 136
I391 (2.28) covaries with -- 5 36 79 354 381 388
V392 (3.74) covaries with -- 6 16 55 133 136 140 143 350 362 371 372
N393 (3.85) covaries with -- 54 55 69 112 114 133 174 206 238 262 266 282 360 371
L394 (4.00) covaries with -- 4 5 6 29 55 66 67 89 114 139 143 165 170 188 206 208 226 267 279 354 361 364 371 372 398
L395 (2.67) covaries with -- 22
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-397 (3.52) covaries with -- 239
-398 (3.52) covaries with -- 147 239 394
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