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Title FDG-PET evaluation of pleural abnormalities
Creator/Author Lowe, V.J. ; Patz, E. ; Harris, P.L. [Duke Univ. Medical Center, Durham, NC (United States)][and others]
Publication Date1994 May 01
OSTI IdentifierOSTI ID: 198088
Report Number(s)CONF-940605--
Other Number(s)JNMEAQ; ISSN 0161-5505
Resource TypeJournal Article
Resource RelationJournal of Nuclear Medicine ; VOL. 35 ; ISSUE: Suppl.5 ; 41. annual meeting of the Society of Nuclear Medicine, Orlando, FL (United States), 5-8 Jun 1994 ; PBD: May 1994
Subject55 BIOLOGY AND MEDICINE, BASIC STUDIES ; FLUORODEOXYGLUCOSE; UPTAKE; POSITRON COMPUTED TOMOGRAPHY; SENSITIVITY; IMAGES; PATIENTS; NEOPLASMS; FLUORINE 18; LABELLED COMPOUNDS; CHEST
Description/Abstract Pleural abnormalities identified on anatomical studies are often nonspecific and may represent benign or malignant disease. We prospectively evaluated the ability of FDG-PET to identify malignancy in patients with pleural abnormalities detected on chest radiographs or chest CT. Thirty-two patients with pleural abnormalities (pleural masses, thickening or effusions) found on chest radiographs or CT were evaluated by FDG-PET. Regions of interest (ROI) were identified on the PET images correlating to anatomic abnormalities and standard uptake ratios (SUR`s) of these ROI`s were calculated. A SUR value of 2.5 or greater was considered positive for malignancy. Physicians blinded to biopsy results graded their confidence of malignancy (1-5 scale) and graded lesion FDG uptake with respect to mediastinal radioactivity. Twenty-three of the patients had definitive diagnoses by tissue biopsy. Seventeen of these patients had malignant (SUR=7.9{plus_minus}3.8) and 6 had benign (SUR=2.8{plus_minus}2.4) causes of their pleural abnormalities (p=0.001). All but two malignant cases had SURs higher than 2.5 and one of these two was correctly interpreted by the observers. SURs lower than 2.5 were seen in four of the six (67%) benign pleural abnormalities. Using a combination of both visual and semiquantitative analysis, the sensitivity of FDG-PET for detecting malignant pleural abnormalities was 94%. Active infections in the pleural space had increased FDG uptake on PET studies while other benign pleural abnormalities did not. FDG-PET has very high sensitivity for detecting malignant pleural abnormalities and can differentiate benign from malignant pleural abnormalities.
Country of PublicationUnited States
LanguageEnglish
Formatpp. 228P-229P.932 ; PL:
System Entry Date2001 May 03

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