Getachew A, Kibrebeal M, Guta Z; International Conference on AIDS.
Int Conf AIDS. 1996 Jul 7-12; 11: 117 (abstract no. Mo.B.1358).
Department of Internal Medicine, Addis Ababa University, Addis Ababa, Ethiopia. Fax: 251-1-513099.
Setting: Black Lion Hospital, a tertiary care referral hospital in Addis Ababa. Objective: To determine the prevalence of HIV-1 infection in patients with pleural tuberculosis and compate the clinical and radiological characteristics, effects and side effects of drugs, compliance to treatment and outcome by HIV status. Methods: A hospital based, prospective study involving 90 adult patients with pleural tuberculosis. 120 surgical patients admitted for non-HIV related conditions served as controls. Results: 22% of the patients with pleural tuberculosis versus 6.7% for the controls (p is less than 0.01) were seropositive for HIV-1. Amongst patients with pleural tuberculosis, HIV seropositive patients were more likely to be male, and had longer duration of illness prior to coming to hospital (P is less than 0.05). They had more disseminated disease (P is less than 0.01), bilateral pleural effusion (P is less than 0.05), adverse reaction to antituberculosis drugs (p is less than 0.05) and increased mortality (p is less than 0.05). Hepatitis was the most common side effect observed. There was no difference in the size of the effusion, clinical improvement, radiographic resolution or defaulter rate. Conclusion: HIV associated pleural tuberculosis commonly occurs with other forms of extra pulmonary TB and responds well to treatment. Hepatitis is a frequent side effect and entails poor prognosis. We therefore recommend careful documentation of a previous history of liver function tests before initiation of treatment. The finding of bilateral pleural effusion may indicate the presence of underlying HIV infection.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Adult
- Ethiopia
- HIV Infections
- HIV Seropositivity
- HIV-1
- Humans
- Male
- Patient Compliance
- Pleural Effusion
- Prevalence
- Prospective Studies
- Tuberculosis, Pleural
- Tuberculosis, Pulmonary
- therapy
Other ID:
UI: 102217320
From Meeting Abstracts