GEDRI - Submit Research Project Inventory Record

Global Endocrine Disruptor Research Initiative
Research Project Inventory Submission

Please fill out the following form to submit a project for the Global Endocrine Disruptor Reseach Inventory.

0. Country

1. Sponsoring Organization (Agency):
1a. Sponsoring Abbreviation:
1b. Full Sponsor Name:

2. Project Title (mandatory field:

3. Project Focus:

primary:
human health effects: ecological effects: exposure assessment:

secondary (if necessary):
human health effects: ecological effects: exposure assessment:

4. Brief Project Description:

Molecular approaches have attained a central position in modern  experimental andhuman toxicology by providing the means to study basic  underlying mechanisms. Molecular methods can be used to identify  casual associations that would otherwise beobscure and to make better  quantitative estimates of these associations at relevantlevels of  exposure. The use of molecular approaches in toxicology should thus  result inbetter estimates of risks to human heath. Toxic effects of  endocrine disruptors can bedivided into two main classes on the basis  of the mechanism of disease causation andreversibility of effects:  traditional deterministic toxicity and stochastic  toxicity.Deterministic toxicity overwhelms the body's compensatory  processes, therebyexceeding the toxicity threshold and leading to  pathological effects; the effects arehowever reversible, up to the  late stages of the disease process. Toxic effects thatarise from  stochastic process have no clear threshold for toxicity, so that  exposure tolow doses of an agent over prolonged periods can give rise  to serious effects that arenot necessarily related to the level of  exposure. Stochastic effects are irreversible orpoorly reversible  when low doses are given in the early stages of the disease. Most  (ifnot all) molecular effects are stochastic; they occur as a result  of a small number ofirreversible changes in the information coded in  DNA, resulting in mutagenesis,carcinogenesis and teratogenesis. Risk  assessment is ultimately based on aquantitative estimate of the dose  of the toxicologically relevant metabolite(s) that isdelivered to  target tissues. A new form of dosimetry is increasingly being  attempted thatis based on the analysis of the products of chemicals  with macromolecules in vivo. Ourstudies include the measurement of DNA  adducts from the target tissues by (1)fluorescence spectroscopy, (2)  the use of monoclonal and polyclonal antibodies, (3)32P- labeling  followed by HPLC separation. Hemoglobin adducts in the exposedanimals  will also be carried out, since there is increasing acceptance that  hemoglobinadducts are a relevant dosimeter of the exposed population.

5. Selected References (max 2):

author:
title:
citation:
year:

author:
title:
citation:
year:

6. Keyword For Inventory Category:

primary: methods: models: measurement:
secondary (if necessary): methods: models: measurement:

7. Keyword For Inventory Subcategory:

primary (only one):
hazard identification: biomakers: exposure and risk models:
basic research: mixtures: exposure determination:
exposure follow up: multidisciplinary research: sentinel species:
database development:

secondary (as many as relevant):
hazard identification: biomakers: exposure and risk models:
basic research: mixtures: exposure determination:
exposure follow up: multidisciplinary research: sentinel species:
database development:

8. Keywords For Experimental System/Species

(as many as relevant)
species:
invertebrates: fish: amphibian: reptilian: avian:
mammalian: rodents: human:
you may add to this list:
add the common and scientific name species:
common: scientific:
study type:
in vitro: in vivo: ex vivo: in computero:
field study: laboratory study: mesocosm study: epidemiology:
fate and transport:
exposure monitoring: environmental fate and transport:
bioaccumulation:

9. Keywords For Experimental Endpoints:

(as many as relevant):
health effect:
carcinogenesis: neurological (incl. behavior): immunology:
reproductive (incl. developmental): other:
hormonal measures:
adrenal hormones: growth factors: hormone receptors:
peptide hormones: pituitary hormones: sex steroids:
thyroid hormones: other:
level of study:
behavior: histopathology: physiology: biochemistry: enzymology:
gene expression: population dynamics: epidemiology:
transgenic model: computer model: other:
chemistry metabolism:
toxicokinetics: tissue residue: xenobiotic metabolism:
cytochrome p450: analyte detection: analyte quantitation: exposure monitoring: physiologically based-pharmacokinetics:
other:
life stage:
female: male: embryo: infant: puberty: adult:
metamorphosis: multigeneration: other:
risk assessment:
biologically based-dose response: risk factors: susceptible subpopulations:

other:

10. Keywords For Agents Under Study:

(as many as relevant):
alkylphenols: anti androgens or androgens: cadmium: chlorotriazines:
diethylstilbestrol: dioxins: anti estrogens or estrogens: fungicides:
herbicides: mercury: metals: lead: organochlorines:
PAHs: PCBs: insecticides: PCDDs: PCDFs: pesticides: phenols:
phthalates: phytoestrogens:
specific name: CAS number:

11. Performing Institution:

12. Contact Person:

Name:
Organization:
Street Address:
City, State, Zip, Country:
* Phone:
* email:

Unformatted:

13. Project ID# (if available):

14. Project Start Date (MM/DD/YYYY):

15. Anticipated Completion Date (MM/DD/YYYY):

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Last Modified: 28 July 1998

Global Endocrine Disruptor Research Initiative Research Project Inventory Submission

http://www.epa.gov/endocrine/AddProject.html

Global Endocrine Disruptor Research Initiative
Research Project Inventory Submission