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Our Science – Waalkes Website

Michael P. Waalkes, Ph.D.

Selected Publications
1)  Pi J, Diwan BA, Sun Y, Liu J, Qu W, He Y, Styblo M, Waalkes MP.
Arsenic-induced malignant transformation of human keratinocytes: Involvement of Nrf2.
Free Radic. Biol. Med. 2008. [Journal]
2)  Liu J, Qian SY, Guo Q, Jiang J, Waalkes MP, Mason RP, Kadiiska MB.
Cadmium generates reactive oxygen- and carbon-centered radical species in rats: Insights from in vivo spin-trapping studies.
Free Radic. Biol. Med. 2008. [Journal]
3)  Waalkes MP, Liu J.
Early-life arsenic exposure: methylation capacity and beyond.
Environ. Health Perspect. 116: A104, 2008. [Journal]
4)  Wu J, Liu J, Waalkes MP, Cheng ML, Li L, Li CX, Yang Q.
High dietary fat exacerbates arsenic-induced liver fibrosis in mice.
Exp. Biol. Med. (Maywood). 233: 377-84, 2008. [Journal]
5)  Benbrahim-Tallaa L, Waalkes MP.
Inorganic arsenic and human prostate cancer.
Environ. Health Perspect. 116: 158-64, 2008. [Journal]
6)  Coppin JF, Qu W, Waalkes MP.
Interplay between cellular methyl metabolism and adaptive efflux during oncogenic transformation from chronic arsenic exposure in human cells.
J. Biol. Chem. 2008. [Journal]
7)  Liu J, Waalkes MP.
Liver is a target of arsenic carcinogenesis.
Toxicol. Sci. 2008. [Journal]
8)  Liu J, Shi JZ, Yu LM, Goyer RA, Waalkes MP.
Mercury in traditional medicines: Is cinnabar toxicologically similar to common mercurials?.
Exp. Biol. Med. (Maywood). 2008. [Journal]
9)  Liu J, Lu Y, Wu Q, Goyer RA, Waalkes MP.
Mineral Aresenicals in Traditional Medicines: Orpiment, Realgar, and Arsenolite.
J. Pharmacol. Exp. Ther. 2008. [Journal]
10)  Shimada H, Yasutake A, Hirashima T, Takamure Y, Kitano T, Waalkes MP, Imamura Y.
Strain difference of cadmium accumulation by liver slices of inbred Wistar-Imamichi and Fischer 344 rats.
Toxicology in vitro : an international journal published in association with BIBRA. 22: 338-43, 2008. [Journal]
11)  Rosen MB, Lee JS, Ren H, Vallanat B, Liu J, Waalkes MP, Abbott BD, Lau C, Corton JC.
Toxicogenomic dissection of the perfluorooctanoic acid transcript profile in mouse liver: evidence for the involvement of nuclear receptors PPAR alpha and CAR.
Toxicol. Sci. 103: 46-56, 2008. [Journal]
12)  Xie Y, Liu J, Benbrahim-Tallaa L, Ward JM, Logsdon D, Diwan BA, Waalkes MP.
Aberrant DNA methylation and gene expression in livers of newborn mice transplacentally exposed to a hepatocarcinogenic dose of inorganic arsenic.
Toxicology. 236: 7-15, 2007. [Journal]
13)  Qu W, Ke H, Pi J, Broderick DK, French JE, Webber MM, Waalkes MP.
Acquisition of apoptotic resistance in cadmium-transformed human prostate epithelial cells: Bcl-2 overexpression blocks the activation of JNK signal transduction pathway.
Environ Health Perspect. 115: 1094-100, 2007. [Journal]
14)  Liu J, Cheng ML, Yang Q, Shan KS, Shen J, Zhou Y, Zhang X, Dill AL, Waalkes MP.
Blood metallothionein transcript as a biomarker for metal sensitivity: low blood metallothionein transcripts in arsenicosis patients from Guizhou, China.
Environ Health Perspect. 115: 1101-6, 2007. [Journal]
15)  Yang Z, Yang S, Qian SY, Hong J, Kadiiska MB, Tennant RW, Waalkes MP, Liu J.
Cadmium-induced toxicity in rat primary mid-brain neuro-glia cultures: role of oxidative stress from microglia.
Toxicol Sci. 98: 488-94, 2007. [Journal]
16)  Benbrahim-Tallaa L, Liu J, Webber MM, Waalkes MP.
Estrogen signaling and disruption of androgen metabolism in acquired androgen-independence during cadmium carcinogenesis in human prostate epithelial cells.
Prostate. 67: 135-45, 2007. [Journal]
17)  Shen J, Liu J, Xie Y, Diwan BA, Waalkes MP.
Fetal onset of aberrant gene expression relevant to pulmonary carcinogenesis in lung adenocarcinoma development induced by in utero arsenic exposure.
Toxicol. Sci. 95: 313-20, 2007. [Journal]
18)  Prozialeck WC, Vaidya VS, Liu J, Waalkes MP, Edwards JR, Lamar PC, Bernard AM, Dumont X, Bonventre JV.
Kidney injury molecule-1 is an early biomarker of cadmium nephrotoxicity.
Kidney Int. 72: 985-93, 2007. [Journal]
19)  Benbrahim-Tallaa L, Webber MM, Waalkes MP.
Mechanisms of acquired androgen independence during arsenic-induced malignant transformation of human prostate epithelial cells.
Environ. Health Perspect. 115: 243-7, 2007. [Journal]
20)  Pi J, Bai Y, Reece JM, Williams J, Liu D, Freeman ML, Fahl WE, Shugar D, Liu J, Qu W, Collins S, Waalkes MP.
Molecular mechanism of human Nrf2 activation and degradation: Role of sequential phosphorylation by protein kinase CK2.
Free Radic. Biol. Med. 42: 1797-806, 2007. [Journal]
21)  Qu W, Liu J, Fuquay R, Saavedra JE, Keefer LK, Waalkes MP.
The nitric oxide prodrug, V-PYRRO/NO, mitigates arsenic-induced liver cell toxicity and apoptosis.
Cancer Lett. 256: 238-45, 2007. [Journal]
22)  Waalkes MP, Liu J, Diwan BA.
Transplacental arsenic carcinogenesis in mice.
Toxicol Appl Pharmacol. 2007. [Journal]
23)  Liu J, Xie Y, Cooper R, Ducharme DM, Tennant R, Diwan BA, Waalkes MP.
Transplacental exposure to inorganic arsenic at a hepatocarcinogenic dose induces fetal gene expression changes in mice indicative of aberrant estrogen signaling and disrupted steroid metabolism.
Toxicol. Appl. Pharmacol. 220: 284-91, 2007. [Journal]
24)  Benbrahim-Tallaa L, Waterland RA, Dill AL, Webber MM, Waalkes MP.
Tumor suppressor gene inactivation during cadmium-induced malignant transformation of human prostate cells correlates with overexpression of de novo DNA methyltransferase.
Environ. Health Perspect. 115: 1454-9, 2007. [Journal]
25)  Qu W, Fuquay R, Sakurai T, Waalkes MP.
Acquisition of apoptotic resistance in cadmium-induced malignant transformation: specific perturbation of JNK signal transduction pathway and associated metallothionein overexpression.
Mol. Carcinog. 45: 561-71, 2006. [Journal]
26)  Devesa V, Adair BM, Liu J, Waalkes MP, Diwan BA, Styblo M, Thomas DJ.
Arsenicals in maternal and fetal mouse tissues after gestational exposure to arsenite.
Toxicology. 224: 147-55, 2006. [Journal]
27)  Ota E, Nagashima Y, Shiomi K, Sakurai T, Kojima C, Waalkes MP, Himeno S.
Caspase-independent apoptosis induced in rat liver cells by plancitoxin I, the major lethal factor from the crown-of-thorns starfish Acanthaster planci venom.
Toxicon. 48: 1002-10, 2006. [Journal]
28)  Kojima C, Qu W, Waalkes MP, Himeno S, Sakurai T.
Chronic exposure to methylated arsenicals stimulates arsenic excretion pathways and induces arsenic tolerance in rat liver cells.
Toxicol. Sci. 91: 70-81, 2006. [Journal]
29)  He YY, Pi J, Huang JL, Diwan BA, Waalkes MP, Chignell CF.
Chronic UVA irradiation of human HaCaT keratinocytes induces malignant transformation associated with acquired apoptotic resistance.
Oncogene. 25: 3680-8, 2006. [Journal]
30)  Li D, An D, Zhou Y, Liu J, Waalkes MP.
Current status and prevention strategy for coal-arsenic poisoning in Guizhou, China.
Journal of health, population, and nutrition. 24: 273-6, 2006. [Journal]
31)  Liu J, Cheng ML, Shi JZ, Yang Q, Wu J, Li CX, Waalkes MP.
Differential effects between maotai and ethanol on hepatic gene expression in mice: Possible role of metallothionein and heme oxygenase-1 induction by maotai.
Exp. Biol. Med. (Maywood). 231: 1535-41, 2006. [Journal]
32)  Sakurai T, Kojima C, Waalkes MP, Himeno S.
Effects of exogenous cysteine on inorganic and organic arsenicals-induced cytolethality.
Appl Organometallic Chem. 20: 549-556, 2006. [Journal]
33)  Waalkes MP, Liu J, Ward JM, Diwan BA.
Enhanced urinary bladder and liver carcinogenesis in male CD1 mice exposed to transplacental inorganic arsenic and postnatal diethylstilbestrol or tamoxifen.
Toxicol. Appl. Pharmacol. 215: 295-305, 2006. [Journal]
34)  Liu J, Benbrahim-Tallaa L, Qian X, Yu L, Xie Y, Boos J, Qu W, Waalkes MP.
Further studies on aberrant gene expression associated with arsenic-induced malignant transformation in rat liver TRL1215 cells.
Toxicol. Appl. Pharmacol. 216: 407-15, 2006. [Journal]
35)  Zhang XJ, Chen DX, Xu HH, Zhao ML, Fang N, Du H, Zhou YS, Cheng ML, Yuan W, Jiang L, Xiao H, Wa QB, Liu LM, Liu J, Waalkes MP.
Increased glycophorin A somatic cell variant frequency in arsenic-exposed patients of Guizhou, China.
Toxicol. Lett. 167: 47-53, 2006. [Journal]
36)  Li GJ, Choi BS, Wang X, Liu J, Waalkes MP, Zheng W.
Molecular mechanism of distorted iron regulation in the blood-CSF barrier and regional blood-brain barrier following in vivo subchronic manganese exposure.
Neurotoxicology. 27: 737-44, 2006. [Journal]
37)  Cover C, Liu J, Farhood A, Malle E, Waalkes MP, Bajt ML, Jaeschke H.
Pathophysiological role of the acute inflammatory response during acetaminophen hepatotoxicity.
Toxicol. Appl. Pharmacol. 216: 98-107, 2006. [Journal]
38)  Sakurai T, Kojima C, Kobayashi Y, Hirano S, Sakurai MH, Waalkes MP, Himeno S.
Toxicity of a trivalent organic arsenic compound, dimethylarsinous glutathione in a rat liver cell line (TRL 1215).
Br. J. Pharmacol. 149: 888-97, 2006. [Journal]
39)  Huff J, Lunn RM, Waalkes MP, Tomatis L, Infante PF.
Cadmium-induced cancers in animals and in humans.
International journal of occupational and environmental health. 13: 202-12, , ,. [Journal]
40)  Liu J, Xie Y, Merrick BA, Shen J, Ducharme DM, Collins J, Diwan BA, Logsdon D, Waalkes MP.
Transplacental arsenic plus postnatal 12-O-teradecanoyl phorbol-13-acetate exposures associated with hepatocarcinogenesis induce similar aberrant gene expression patterns in male and female mouse liver.
Toxicol. Appl. Pharmacol. 213: 216-23, 2006. [Journal]
41)  Waalkes MP, Liu J, Kasprzak KS, Diwan BA.
Hypersusceptibility to cisplatin carcinogenicity in metallothionein-I/II double knockout mice: production of hepatocellular carcinoma at clinically relevant doses.
Int. J. Cancer. 119: 28-32, 2006. [Journal]
42)  Liu J, Xie Y, Ducharme DM, Shen J, Diwan BA, Merrick BA, Grissom SF, Tucker CJ, Paules RS, Tennant R, Waalkes MP.
Global gene expression associated with hepatocarcinogenesis in adult male mice induced by in utero arsenic exposure.
Environ. Health Perspect. 114: 404-11, 2006. [Journal]
43)  Fickert P, Wagner M, Marschall HU, Fuchsbichler A, Zollner G, Tsybrovskyy O, Zatloukal K, Liu J, Waalkes MP, Cover C, Denk H, Hofmann AF, Jaeschke H, Trauner M.
24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice.
Gastroenterology. 130: 465-81, 2006. [Journal]
44)  Waalkes MP, Liu J, Ward JM, Powell DA, Diwan BA.
Urogenital carcinogenesis in female CD1 mice induced by in utero arsenic exposure is exacerbated by postnatal diethylstilbestrol treatment.
Cancer Res. 66: 1337-45, 2006. [Journal]
45)  Shen J, Wanibuchi H, Waalkes MP, Salim EI, Kinoshita A, Yoshida K, Endo G, Fukushima S.
A comparative study of the sub-chronic toxic effects of three organic arsenical compounds on the urothelium in F344 rats; gender-based differences in response.
Toxicol. Appl. Pharmacol. 210: 171-80, 2006. [Journal]
46)  Leslie EM, Liu J, Klaassen CD, Waalkes MP.
Acquired cadmium resistance in metallothionein-I/II(-/-) knockout cells: role of the T-type calcium channel Cacnalpha1G in cadmium uptake.
Mol. Pharmacol. 69: 629-39, 2006. [Journal]
47)  Kojima C, Sakurai T, Waalkes MP, Himeno S.
Cytolethality of glutathione conjugates with monomethylarsenic or dimethylarsenic compounds.
Biol. Pharm. Bull. 28: 1827-32, 2005. [Journal]
48)  Benbrahim-Tallaa L, Webber MM, Waalkes MP.
Acquisition of androgen independence by human prostate epithelial cells during arsenic-induced malignant transformation.
Environ. Health Perspect. 113: 1134-9, 2005. [Journal]
49)  Waalkes MP, Liu J, Kasprzak KS, Diwan BA.
Metallothionein-I/II double knockout mice are no more sensitive to the carcinogenic effects of nickel subsulfide than wild-type mice.
International journal of toxicology. 24: 215-20, , ,. [Journal]
50)  Benbrahim-Tallaa L, Waterland RA, Styblo M, Achanzar WE, Webber MM, Waalkes MP.
Molecular events associated with arsenic-induced malignant transformation of human prostatic epithelial cells: aberrant genomic DNA methylation and K-ras oncogene activation.
Toxicol. Appl. Pharmacol. 206: 288-98, 2005. [Journal]
51)  Liu J, He YY, Chignell CF, Clark J, Myers P, Saavedra JE, Waalkes MP.
Limited protective role of V-PYRRO/NO against cholestasis produced by alpha-naphthylisothiocyanate in mice.
Biochem. Pharmacol. 70: 144-51, 2005. [Journal]
52)  Sakurai T, Ochiai M, Kojima C, Ohta T, Sakurai MH, Takada NO, Qu W, Waalkes MP, Himeno S, Fujiwara K.
Preventive mechanism of cellular glutathione in monomethylarsonic acid-induced cytolethality.
Toxicol. Appl. Pharmacol. 206: 54-65, 2005. [Journal]
53)  Liu J, Waalkes MP.
Nitric oxide and chemically induced hepatotoxicity: beneficial effects of the liver-selective nitric oxide donor, V-PYRRO/NO.
Toxicology. 208: 289-97, 2005. [Journal]
54)  Qu W, Diwan BA, Reece JM, Bortner CD, Pi J, Liu J, Waalkes MP.
Cadmium-induced malignant transformation in rat liver cells: role of aberrant oncogene expression and minimal role of oxidative stress.
Int J Cancer. 114: 346-55, 2005. [Journal]
55)  Pi J, Yamauchi H, Sun G, Yoshida T, Aikawa H, Fujimoto W, Iso H, Cui R, Waalkes MP, Kumagai Y.
Vascular dysfunction in patients with chronic arsenosis can be reversed by reduction of arsenic exposure.
Environ Health Perspect. 113: 339-41, 2005. [Journal]
56)  Qu W, Liu J, Fuquay R, Shimoda R, Sakurai T, Saavedra JE, Keefer LK, Waalkes MP.
The nitric oxide prodrug, V-PYRRO/NO, protects against cadmium toxicity and apoptosis at the cellular level.
Nitric Oxide. 12: 114-20, 2005. [Journal]
57)  Stauber AJ, Brown-Borg H, Liu J, Waalkes MP, Laughter A, Staben RA, Coley JC, Swanson C, Voss KA, Kopchick JJ, Corton JC.
Constitutive expression of peroxisome proliferator-activated receptor alpha-regulated genes in dwarf mice.
Mol Pharmacol. 67: 681-94, 2005. [Journal]
58)  Liu J, Waalkes M.
Focal adhesion kinase as a potential target in arsenic toxicity.
Toxicol Sci. 84: 212-3, 2005. [Journal]
59)  Lang JY, Chen H, Zhou J, Zhang YX, Zhang XW, Li MH, Lin LP, Zhang JS, Waalkes MP, Ding J.
Antimetastatic effect of salvicine on human breast cancer MDA-MB-435 orthotopic xenograft is closely related to Rho-dependent pathway.
Clin Cancer Res. 11: 3455-64, 2005. [Journal]
60)  Pi J, He Y, Bortner C, Huang J, Liu J, Zhou T, Qu W, North SL, Kasprzak KS, Diwan BA, Chignell CF, Waalkes MP.
Low level, long-term inorganic arsenite exposure causes generalized resistance to apoptosis in cultured human keratinocytes: Potential role in skin co-carcinogenesis.
Int J Cancer. 116: 20-6, 2005. [Journal]
61)  Xie Y, Trouba KJ, Liu J, Waalkes MP, Germolec DR.
Biokinetics and subchronic toxic effects of oral arsenite, arsenate, monomethylarsonic acid, and dimethylarsinic acid in v-Ha-ras transgenic (Tg.AC) mice.
Environ Health Perspect. 112: 1255-63, 2004. [Journal]
62)  Waalkes MP, Liu J, Goyer RA, Diwan BA.
Metallothionein-I/II double knockout mice are hypersensitive to lead-induced kidney carcinogenesis: role of inclusion body formation.
Cancer Res. 64: 7766-72, 2004. [Journal]
63)  Shimada H, Takamure Y, Shimada A, Yasutake A, Waalkes MP, Imamura Y.
Strain differences of cadmium-induced hepatotoxicity in Wistar-Imamichi and Fischer 344 rats: involvement of cadmium accumulation.
Toxicology. 203: 189-97, 2004. [Journal]
64)  Waalkes MP, Liu J, Kasprzak KS, Diwan BA.
Minimal influence of metallothionein over-expression on nickel carcinogenesis in mice.
Toxicol Lett. 153: 357-64, 2004. [Journal]
65)  Zhou T, Jia X, Chapin RE, Maronpot RR, Harris MW, Liu J, Waalkes MP, Eddy EM.
Cadmium at a non-toxic dose alters gene expression in mouse testes.
Toxicol Lett. 154: 191-200, 2004. [Journal]
66)  Goyer RA, Liu J, Waalkes MP.
Cadmium and cancer of prostate and testis.
Biometals. 17: 555-8, 2004. [Journal]
67)  Waalkes MP, Liu J, Chen H, Xie Y, Achanzar WE, Zhou YS, Cheng ML, Diwan BA.
Estrogen signaling in livers of male mice with hepatocellular carcinoma induced by exposure to arsenic in utero.
J Natl Cancer Inst. 96: 466-74, 2004. [Journal]
68)  Leslie EM, Haimeur A, Waalkes MP.
Arsenic transport by the human multidrug resistance protein 1 (MRP1/ABCC1). Evidence that a tri-glutathione conjugate is required.
J Biol Chem. 279: 32700-8, 2004. [Journal]
69)  Chen H, Li S, Liu J, Diwan BA, Barrett JC, Waalkes MP.
Chronic inorganic arsenic exposure induces hepatic global and individual gene hypomethylation: implications for arsenic hepatocarcinogenesis.
Carcinogenesis. 25: 1779-1786, 2004. [Journal]
70)  Liu J, Qu W, Saavedra JE, Waalkes MP.
The nitric oxide donor, O2-vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (V-PYRRO/NO), protects against cadmium-induced hepatotoxicity in mice.
J Pharmacol Exp Ther. 310: 18-24, 2004. [Journal]
71)  Wang AG, Xia T, Yuan J, Yu RA, Yang KD, Chen XM, Qu W, Waalkes MP.
Effects of phenobarbital on metabolism and toxicity of diclofenac sodium in rat hepatocytes in vitro.
Food Chem Toxicol. 42: 1647-53, 2004. [Journal]
72)  Liu J, Walker N, Waalkes MP.
Hybridization buffer systems impact the quality of filter array data.
J Pharmacol Toxicol Methods. 50: 67-71, 2004. [Journal]
73)  Waalkes MP, Liu J, Ward JM, Diwan BA.
Animal models for arsenic carcinogenesis: inorganic arsenic is a transplacental carcinogen in mice.
Toxicol Appl Pharmacol. 198: 377-84, 2004. [Journal]
74)  Sakurai T, Ochiai M, Kojima C, Ohta T, Sakurai MH, Takada NO, Qu W, Waalkes MP, Fujiwara K.
Role of glutathione in dimethylarsinic acid-induced apoptosis.
Toxicol Appl Pharmacol. 198: 354-65, 2004. [Journal]
75)  Yamauchi H, Aminaka Y, Yoshida K, Sun G, Pi J, Waalkes MP.
Evaluation of DNA damage in patients with arsenic poisoning: urinary 8-hydroxydeoxyguanine.
Toxicol Appl Pharmacol. 198: 291-6, 2004. [Journal]
76)  Liu J, Li C, Qu W, Leslie E, Bonifant CL, Buzard GS, Saavedra JE, Keefer LK, Waalkes MP.
Nitric oxide prodrugs and metallochemotherapeutics: JS-K and CB-3-100 enhance arsenic and cisplatin cytolethality by increasing cellular accumulation.
Mol Cancer Ther. 3: 709-14, 2004. [Journal]
77)  Jiang JG, Tang JB, Chen CL, Liu BX, Fu XN, Zhu ZH, Qu W, Cianflone K, Waalkes MP, Wang DW.
Expression of cyclooxygenase-2 in human esophageal squamous cell carcinomas.
World J Gastroenterol. 10: 2168-73, 2004. [Journal]
78)  Achanzar WE, Lamar P, Tokar EJ, Rivette AS, DeOcampo D, Prozialeck WC, Webber MM, Waalkes MP.
Human prostate cell lines mimic heterogeneity of cadherin expression in human prostate cancer.
UroOncology. 4: 15-25, 2004. [Journal]
79)  Jiang Y, Liu J, Waalkes M, Kang YJ.
Changes in the gene expression associated with carbon tetrachloride-induced liver fibrosis persist after cessation of dosing in mice.
Toxicol Sci. 79: 404-10, 2004. [Journal]
80)  Waalkes MP, Liu J, Ward JM, Diwan BA.
Mechanisms underlying arsenic carcinogenesis: hypersensitivity of mice exposed to inorganic arsenic during gestation.
Toxicology. 198: 31-8, 2004. [Journal]
81)  Sakurai T, Kojima C, Ochiai M, Ohta T, Sakurai MH, Waalkes MP, Fujiwara K.
Cellular glutathione prevents cytolethality of monomethylarsonic acid.
Toxicol Appl Pharmacol. 195: 129-41, 2004. [Journal]
82)  Waalkes MP, Ward JM, Diwan BA.
Induction of tumors of the liver, lung, ovary and adrenal in adult mice after brief maternal gestational exposure to inorganic arsenic: promotional effects of postnatal phorbol ester exposure on hepatic and pulmonary, but not dermal cancers.
Carcinogenesis. 25: 133-41, 2004. [Journal]
83)  Liu J, Xie Y, Ward JM, Diwan BA, Waalkes MP.
Toxicogenomic analysis of aberrant gene expression in liver tumors and nontumorous livers of adult mice exposed in utero to inorganic arsenic.
Toxicol Sci. 77: 249-57, 2004. [Journal]
84)  He YY, Huang JL, Sik RH, Liu J, Waalkes MP, Chignell CF.
Expression profiling of human keratinocyte response to ultraviolet A: implications in apoptosis.
J Invest Dermatol. 122: 533-43, 2004. [Journal]
85)  Kowara R, Salnikow K, Diwan BA, Bare RM, Waalkes MP, Kasprzak KS.
Reduced Fhit protein expression in nickel-transformed mouse cells and in nickel-induced murine sarcomas.
Mol Cell Biochem. 255: 195-202, 2004. [Journal]
86)  Xie Y, Liu J, Liu Y, Klaassen CD, Waalkes MP.
Toxicokinetic and genomic analysis of chronic arsenic exposure in multidrug-resistance mdr1a/1b(-/-) double knockout mice.
Mol Cell Biochem. 255: 11-8, 2004. [Journal]
87)  Pi J, Qu W, Reece JM, Kumagai Y, Waalkes MP.
Transcription factor Nrf2 activation by inorganic arsenic in cultured keratinocytes: involvement of hydrogen peroxide.
Exp Cell Res. 290: 234-45, 2003. [Journal]
88)  Waalkes MP.
Cadmium carcinogenesis.
Mutat Res. 533: 107-20, 2003. [Journal]
89)  Rossman TG, Waalkes MP.
Commentary: Metals and human cancer.
Mutat Res. 533: 1-2, 2003. [Journal]
90)  Shankar K, Vaidya VS, Corton JC, Bucci TJ, Liu J, Waalkes MP, Mehendale HM.
Activation of PPAR-alpha in streptozotocin-induced diabetes is essential for resistance against acetaminophen toxicity.
FASEB J. 17: 1748-50, 2003. [Journal]
91)  Li C, Luo J, Li L, Cheng M, Huang N, Liu J, Waalkes MP.
The collagenolytoic effects of the traditional Chinese medicine preparation, Han-Dan-Gan-Le, on carbon tetrachloride-induced liver fibrosis in rats.
Life Sci. 72: 1563-71, 2003. [Journal]
92)  Li C, Liu J, Waalkes MP, Jaeschke H.
Gene array analysis of the hepatic response to endotoxin in glutathione peroxidase-deficient mice.
Toxicol Lett. 144: 397-406, 2003. [Journal]
93)  Pi J, Horiguchi S, Sun Y, Nikaido M, Shimojo N, Hayashi T, Yamauchi H, Itoh K, Yamamoto M, Sun G, Waalkes MP, Kumagai Y.
A potential mechanism for the impairment of nitric oxide formation caused by prolonged oral exposure to arsenate in rabbits.
Free Radic Biol Med. 35: 102-13, 2003. [Journal]
94)  Li C, Liu J, Saavedra JE, Keefer LK, Waalkes MP.
The nitric oxide donor, V-PYRRO/NO, protects against acetaminophen-induced nephrotoxicity in mice.
Toxicology. 189: 173-80, 2003. [Journal]
95)  Liu J, Lei D, Waalkes MP, Beliles RP, Morgan DL.
Genomic analysis of the rat lung following elemental mercury vapor exposure.
Toxicol Sci. 74: 174-81, 2003. [Journal]
96)  Shimoda R, Achanzar WE, Qu W, Nagamine T, Takagi H, Mori M, Waalkes MP.
Metallothionein is a potential negative regulator of apoptosis.
Toxicol Sci. 73: 294-300, 2003. [Journal]
97)  Takiguchi M, Achanzar WE, Qu W, Li G, Waalkes MP.
Effects of cadmium on DNA-(cytosine-5) methyltransferase activity and DNA methylation status during cadmium-induced cellular transformation.
Exp Cell Res. 286: 355-65, 2003. [Journal]
98)  Liu J, Li C, Waalkes MP, Clark J, Myers P, Saavedra JE, Keefer LK.
The nitric oxide donor, V-PYRRO/NO, protects against acetaminophen-induced hepatotoxicity in mice.
Hepatology. 37: 324-33, 2003. [Journal]
99)  Waalkes MP, Ward JM, Liu J, Diwan BA.
Transplacental carcinogenicity of inorganic arsenic in the drinking water: Induction of hepatic, ovarian, pulmonary and adrenal tumors in mice.
Toxicol Appl Pharmacol. 186: 7-17, 2003. [Journal]
100)  Liu J, Chen H, Kadiiska M, Xie Y, Waalkes MP.
Application of filter arrays in the study of arsenic toxicity and carcinogenesis. In: Chappel WR (Ed).
Arsenic Exposure and Health Effects. Amsterdam, Elsevier: 295-303, 2003. [Journal]
101)  Achanzar WE, Brambila EM, Diwan BA, Webber MM, Waalkes MP.
Inorganic arsenite-induced malignant transformation of human prostate epithelial cells.
J Natl Cancer Inst. 94: 1888-91, 2002. [Journal]
102)  Achanzar WE, Webber MM, Waalkes MP.
Altered apoptotic gene expression and acquired apoptotic resistance in cadmium-transformed human prostate epithelial cells.
Prostate. 52: 236-44, 2002. [Journal]
103)  Qu W, Diwan BA, Liu J, Goyer RA, Dawson T, Horton JL, Cherian MG, Waalkes MP.
The metallothionein-null phenotype is associated with heightened sensitivity to lead toxicity and an inability to form inclusion bodies.
Am J Pathol. 160: 1047-56, 2002. [Journal]
104)  Qu W, Ikejima K, Zhong Z, Waalkes MP, Thurman RG.
Glycine blocks the increase in intracellular free Ca2+ due to vasoactive mediators in hepatic parenchymal cells.
Am J Physiol Gastrointest Liver Physiol. 283: G1249-56, 2002. [Journal]
105)  Chen H, Liu J, Waalkes MP.
Molecular changes associated with arsenic-induced malignant transformation in rodent liver cells: A review.
Biomed Res Trace Elements. 13: 186-91, 2002. [Journal]
106)  Brambila EM, Achanzar WE, Qu W, Webber MM, Waalkes MP.
Chronic arsenic-exposed human prostate epithelial cells exhibit stable arsenic tolerance: mechanistic implications of altered cellular glutathione and glutathione S-transferase.
Toxicol Appl Pharmacol. 183: 99-107, 2002. [Journal]
107)  Sakurai T, Qu W, Sakurai MH, Waalkes MP.
A major human arsenic metabolite, dimethylarsinic acid, requires reduced glutathione to induce apoptosis.
Chem Res Toxicol. 15: 629-37, 2002. [Journal]
108)  Liu J, Saavedra JE, Lu T, Song JG, Clark J, Waalkes MP, Keefer LK.
O(2)-Vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate protection against D-galactosamine/endotoxin-induced hepatotoxicity in mice: genomic analysis using microarrays.
J Pharmacol Exp Ther. 300: 18-25, 2002. [Journal]
109)  Liu J, Kadiiska MB, Corton JC, Qu W, Waalkes MP, Mason RP, Liu Y, Klaassen CD.
Acute cadmium exposure induces stress-related gene expression in wild-type and metallothionein-I/II-null mice.
Free Radic Biol Med. 32: 525-35, 2002. [Journal]
110)  Qu W, Bortner CD, Sakurai T, Hobson MJ, Waalkes MP.
Acquisition of apoptotic resistance in arsenic-induced malignant transformation: role of the JNK signal transduction pathway.
Carcinogenesis. 23: 151-9, 2002. [Journal]
111)  Liu J, Liu Y, Powell DA, Waalkes MP, Klaassen CD.
Multidrug-resistance mdr1a/1b double knockout mice are more sensitive than wild type mice to acute arsenic toxicity, with higher arsenic accumulation in tissues.
Toxicology. 170: 55-62, 2002. [Journal]
112)  Liu J, Zheng B, Aposhian HV, Zhou Y, Chen ML, Zhang A, Waalkes MP.
Chronic arsenic poisoning from burning high-arsenic-containing coal in Guizhou, China.
Environ Health Perspect. 110: 119-22, 2002. [Journal]
113)  Kuester RK, Waalkes MP, Goering PL, Fisher BL, McCuskey RS, Sipes IG.
Differential hepatotoxicity induced by cadmium in Fischer 344 and Sprague-Dawley rats.
Toxicol Sci. 65: 151-9, 2002. [Journal]
114)  Brambila E, Liu J, Morgan DL, Beliles RP, Waalkes MP.
Effect of mercury vapor exposure on metallothionein and glutathione s-transferase gene expression in the kidney of nonpregnant, pregnant, and neonatal rats.
J Toxicol Environ Health A. 65: 1273-88, 2002. [Journal]
115)  Achanzar WE, Diwan BA, Liu J, Quader ST, Webber MM, Waalkes MP.
Cadmium-induced malignant transformation of human prostate epithelial cells.
Cancer Res. 61: 455-58, 2001. [Journal]
116)  Liu J, Chen H, Miller DS, Saavedra JE, Keefer LK, Johnson DR, Klaassen CD, Waalkes MP.
Overexpression of glutathione S-transferase-pi and multidrug resistance transport proteins is associated with acquired tolerance to inorganic arsenic.
Mol. Pharmacol. 60: 302-9, 2001. [Journal]
117)  Chen H, Liu J, Merrick BA, Waalkes MP.
Genetic events associated with arsenic-induced malignant transformation: applications of cDNA microarray technology.
Mol Carcinog. 30: 79-87, 2001. [Journal]
118)  Liu J, Corton C, Dix DJ, Liu Y, Waalkes MP, Klaassen CD.
Genetic background but not metallothionein phenotype dictates sensitivity to cadmium-induced testicular injury in mice.
Toxicol Appl Pharmacol. 176: 1-9, 2001. [Journal]
119)  Chen H, Liu J, Zhao CQ, Diwan BA, Merrick BA, Waalkes MP.
Association of c-myc overexpression and hyperproliferation with arsenite-induced malignant transformation.
Toxicol Appl Pharmacol. 175: 260-8, 2001. [Journal]
120)  Qu W, Kasprzak KS, Kadiiska M, Liu J, Chen H, Maciag A, Mason RP, Waalkes MP.
Mechanisms of arsenic-induced cross-tolerance to nickel cytotoxicity, genotoxicity, and apoptosis in rat liver epithelial cells.
Toxicol Sci. 63: 189-95, 2001. [Journal]

This page was last updated on 6/24/2008.