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Tuan Vo Dinh Oak Ridge National Laboratory |
Keywords:
Biomedical photonics, biosensors, biochips, biotechnology for the study of gene expression and functional genomics; development of novel medical diagnostics technology for the detection of cancer, diabetes and heart diseases.
Description of Research:
The focus of the laboratory of T. Vo-Dinh involves the investigation and development of novel methods and advanced technologies for the study of gene expression, gene function, and applications in biomedical diagnostics and therapy.Some areas of current research interests are:
- Study of molecular and electronic spectroscopies of biological compounds of biomedical interests.
- Investigation and development of a laser-induced methods using luminescence and Raman spectroscopies.
- Investigation of structural characterization of biological compounds
such as carcinogens and drugs in biomembrane systems. - Development of antibody-based fluoro-immuno sensors for the detection
of toxicologically important compounds in microsamples of body fluids or in single cells for gene expression study. - Investigation of molecular spectroscopies of tumors and development
of the non-invasive laser-based "optical biopsy" for biomedical diagnosis: cancer, diabetes, heart diseases. - Investigation of novel methods for study gene function.
- Development of a novel integrated biochip for gene diagnostics.
- Development of novel technologies for high-thoughput drug screening.
Selected Publications:
- Cullum, B.M., G.D. Griffin, G.H. Miller, and T. Vo-Dinh, Intracellular Measurements in Mammary Carcinoma Cells Using Fiber-optic Nanosensors, Anal. Biochem., 277, 25 (2000).
- Vo-Dinh, T., J. P. Alaire, B. M. Cullum, G. D. Griffin, Antibody-based Nanoprobe for Measurements of a Fluorescent Analyte in a Single Cell, Nature Biotechnology, 18, July 2000.
- Vo-Dinh T. B.M. Cullum, and D.L. Stokes, Nanosensors and Biochips: Frontiers in Biomolecular Diagnostics, Sensors and Actuators, B 74, 2 (2001).
- T. Vo-Dinh,Nano-Biosensors: Probing the Sanctuary of Individual Living Cells.” Journal of Cellular Biochemistry, Suppl. Vol. 39, 154 (2002).
- M. Culha, D.L. Stokes, L. R. Allain, and T.Vo-Dinh, Surface-enhanced Raman scattering (SERS) Substrate Based on Self-assembled Monolayer (SAM) for Use in Gene Diagnostics, Anal. Chem., 75, 6196-6201 (2003).
- T. Vo-Dinh, G.D. Griffin, D.L. Stokes and A. L. Wintenberg, Multi-functional Biochip for Medical Diagnostics and Pathogen Detection, Sensors and Actuators B, 90, 104 (2003)
- P.M. Kasili, J. M. Song, and T. Vo-Dinh, Optical Sensor for the Detection of Caspase-9 Activity in a Single Cell, J. Am. Chem. Soc., 126, 2799-2806 (2004).