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Abstract
Grant Number: 1R01ES014065-01A1 Project Title: Comparative Toxicogenomics Database (CTD)
PI Information: Name Title BOYER, JAMES L. james.boyer@yale.edu PROFESSOR Abstract: DESCRIPTION (provided by applicant): The goal of this proposal is to establish an authoritative public database, the Comparative Toxicogenomics Database (CTD; http://ctd.mdibl.org), that promotes understanding about the effects of environmental chemicals on human health. The etiology of most chronic diseases involves interactions between environmental and genetic factors. Although more than 85,000 chemicals are used in commerce today, the complex molecular mechanisms underlying the actions of most of these chemicals and their effects on human health are poorly understood. In CTD we will present scientifically reviewed information on environmental chemicals, significant genes, and their interactions in vertebrates and invertebrates. The specific aims of this proposal are to: 1) curate and integrate chemical-gene interactions from published literature and high-throughput experimental data (e.g., microarrays); 2) curate cross-species toxicologically important genes and their proteins; and 3) transform the CTD prototype into a robust, production-quality database ready for increased public use and more sophisticated data search and analysis capabilities. CTD will be the first database to focus its curation on chemical-gene interactions and genes of toxicological significance in diverse species to elucidate structure-function correlations. These data will be key to building network models of chemical actions and providing important insights into differences in susceptibility to environmentally-induced toxicity and disease. Insights from CTD will also have important implications for toxicity prediction and environmental regulation. We are developing the publicly available Comparative Toxicogenomics Database (CTD) to promote understanding about the effects of environmental chemicals on human health. CTD will provide information on significant chemicals, genes, and their interactions in vertebrates and invertebrates. These data will provide important insights into the mechanisms of chemical actions and the genetic basis of differential toxicity among organisms and individuals, and will also have important implications for toxicity prediction and environmental regulation.
Public Health Relevance:
This Public Health Relevance is not available.Thesaurus Terms:
chemical information system, environmental health, environmental toxicology, gene environment interaction, molecular biology information system, toxicology information system
chemical structure function, data quality /integrity, disease /disorder etiology, environmental contamination, environmental exposure, gene expression, information retrieval, literature citation, microarray technology, protein structure function, species difference
Institution: MOUNT DESERT ISLAND BIOLOGICAL LAB Old Bar Harbor Road Salisbury Cove, ME 04672 Fiscal Year: 2006 Department: Project Start: 18-AUG-2006 Project End: 30-APR-2011 ICD: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES IRG: ZRG1