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Sponsored by: |
National Institute on Alcohol Abuse and Alcoholism (NIAAA) |
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Information provided by: | National Institutes of Health Clinical Center (CC) |
ClinicalTrials.gov Identifier: | NCT00001675 |
This study was designed to learn more about the areas of the brain involved in the experience of positive and negative emotions.
Patients who would like to participate in this study will first undergo a screening process to see if they will be eligible for the study. Patients eligible to participate in the study will go through two sessions.
During session one, researchers will attempt to evoke positive and negative emotions by showing patients slides of different emotion-arousing stimuli (pictures of pleasant and unpleasant scenes). While patients are viewing these slides, researchers will be measuring patient's heart rate, sweating, and eye-blinking.
During session two, patients will undergo an MRI of the brain while seeing similar emotion-arousing pictures as in session one. In addition, patients may be asked to play a simple computer game for a reward of money while researchers use the MRI to measure brain activity.
Researchers hope to develop methods to evoke positive and negative emotions and simultaneously (at the same time) see brain activation in normal volunteers, alcoholics, and recovered alcoholics.
Condition |
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Alcoholism Healthy |
Study Type: | Observational |
Official Title: | Functional Neuroanatomy of Positive and Negative Affect in Alcoholics and Non-Alcoholics |
Estimated Enrollment: | 1420 |
Study Start Date: | January 1998 |
Objective:
The purpose of this protocol is three fold: 1) to develop methods with which we can evoke positive and negative affect and visualize concomitant brain activation in normal controls, alcoholics, and recovering alcoholics, 2) to determine how individual differences in evoked brain responses relate to generalized trait personality and behavior differences (as assessed by psychometric questionnaire instruments and behavioral measures, and 3) to determine whether individual differences in evoked brain responses relate specifically to genetic polymorphisms in genes governing neurotransmitter activity.
Study population:
Health non-alcoholic adult volunteers, healthy adolescents aged 12 to 18 years (with or without a family history of alcohol use disorder), inpatient or outpatient alcoholics, and recovering alcoholics.
Design:
In this event-related functional magnetic resonance imaging (fMRI) study we will attempt to evoke positive and negative affect via several different standardized methods including: (1) pictures of emotion-arousing stimuli; (2) pictures of emotional facial expression; (3) cues signaling reward or punishment. This is an omnibus protocol designed to cover many different functional magnetic imaging studies all using similar techniques to evoke and measure positive and negative affect in the brain. Most subjects will not participate in studies involving all methods described in the protocol.
Outcome measures:
The outcome measure is differences in blood oxygenation dependent level (BOLD) signal measured using standard fMRI techniques and analyzed using AFNI software.
Ages Eligible for Study: | 12 Years to 65 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Adult subjects will participate only if they:
Are physically healthy.
Are between 18-65 years of age.
Have 20/40 vision or corrected to 20/40
Are right handed.
Have no ferromagnetic objects in their bodies which might be adversely affected by MRI (e.g. surgical clips; metal fragments in or near brain; eye or blood vessels; cardiac or neurological pacemaker; cochlear or eye implant - any doubt about presence of these objects will result in exclusion from this study).
Test HIV negative (since AIDS-related dementia compromises brain function).
Have no indication of any organic brain syndrome.
Have no active homicidal or suicidal ideation, or active symptoms of post-traumatic stress disorder.
Are not currently receiving psychotropic medication for emotional distress.
Are not pregnant or lactating.
Are not having any symptoms of alcohol withdrawal at the time of scan.
Adolescents will be subject to the same screening criteria. However, diagnosis of DSM-IV Axis I disorders Conduct Disorder, Attention Deficit Hyperactivity Disorder, Oppositional Defiant Disorder, Anxiety Disorders, and Mood Disorders will not be exclusion criteria in adolescent subjects.
Contact: Patient Recruitment and Public Liaison Office | (800) 411-1222 | prpl@mail.cc.nih.gov |
Contact: TTY | 1-866-411-1010 |
United States, Maryland | |
National Institutes of Health Clinical Center, 9000 Rockville Pike | Recruiting |
Bethesda, Maryland, United States, 20892 |
Study ID Numbers: | 980056, 98-AA-0056 |
Study First Received: | November 3, 1999 |
Last Updated: | January 31, 2009 |
ClinicalTrials.gov Identifier: | NCT00001675 |
Health Authority: | United States: Federal Government |
Brain Imaging Affect Limbic System Cerebral Blood Volume Alcoholism Emotion |
Brain Operant Autonomic Relapse Normal Volunteer |
Mental Disorders Alcoholism Substance-Related Disorders |
Disorders of Environmental Origin Alcohol-Related Disorders Healthy |