DAVID Gene Report
2864983
leukemia inhibitory factor (cholinergic differentiation factor) Related Genes Homo sapiens
SP_COMMENT
function:LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.,
pharmaceutical:In phase II clinical trial. The drug is being developed by Amrad to assist embryo implantation in women who have failed to become pregnant despite assisted reproductive technologies (ART).,
similarity:Belongs to the LIF/OSM family.,
subcellular location:Secreted.,
ENTREZ_GENE_SUMMARY
Leukaemia inhibitory factor is a cytokine that induces macrophage differentiation. Neurotransmitters and neuropeptides, well known for their role in the communication between neurons, are also capable of activating monocytes and macrophages and inducing chemotaxis in immune cells. LIF signals through different receptors and transcription factors. LIF in conjunction with BMP2 acts in synergy on primary fetal neural progenitor cells to induce astrocytes.,
GENPEPT_ACCESSION
AAA51699 ,
AAA53188 ,
AAA59517 ,
AAC05174 ,
AAH69540 ,
AAH93733 ,
AAH93735 ,
CAA32147 ,
EAW59863 ,
Genomic_DNA ,
JOINED ,
mRNA ,
GENE_SYMBOL
LIF ,
GENE_NAME
D factor,
Differentiation-stimulating factor,
Emfilermin,
LIF,
Leukemia inhibitory factor precursor,
MLPLI,
Melanoma-derived LPL inhibitor,
leukemia inhibitory factor (cholinergic differentiation factor),
GENERIF_SUMMARY
LIF stimulates proliferation of rat pituitary tumor cells in culture, inhibits secretion of prolactin and growth hormone and induces tyrosine phosphorylation of STAT3 in the cells. ,
The entire structure of the LIF gene of 48 alleles in the Japanese population was sequenced. ,
Oncostatin M and leukemia inhibitory factor regulate the growth of normal human breast epithelial cells ,
LIF does not activate STAT3, ERK, or gp130 receptor in human N tera-2/D1 EC cells. The suppressor of cytokine signaling 1 (SOCS-1) is constitutively expressed, suggesting that LIF signal transduction is inhibited by elevated levels of SOCS-1 expression. ,
experimental N-Myc overexpression results in down-regulation of leukemia inhibitory factor (LIF), a modulator of endothelial cell proliferation ,
LIF stimulates (45)Ca release and enhances expression of receptor activator of NF-kappa B ligand (RANKL) and osteoprotegerin in neonatal mouse calvarial cultures, but has no effect on the expression of RANK. ,
role for LIF in loss of autocrine prolactin suppression contributing to unrestrained prolactinomas prolactin secretion. ,
LIF regulates cell survival of normal human endometrial stromal cells dose-dependently. ,
Leukemia inhibitory factor (LIF), cardiotrophin-1, and oncostatin M share structural binding determinants in the immunoglobulin-like domain of LIF receptor ,
LIF has a role in src family kinase-independent signal transduction and gene induction ,
Leukemia inhibitory factor (LIF) increased overall expansion of human neural precursor cells grown in culture; Following LIF withdrawal, 200 genes showed significant decreases ,
binding of ETS transcription factors to the ETS binding sites in the human LIF promoter is critical for its inducibility in response to T cell activators and play an important functional role within the endocrine-immune network. ,
role in hepatocyte growth factor expression ,
Decreased concentartion of LIF in infertile women do not seem to have a genetic basis due to the low frequency of LIF gene alterations. ,
Constitutive expression of cytokines in brain induces changes in gene expression characteristic of chronic inflammation leading to either temporal weight reduction (CNTF) or severe cachexia (leukemia inhibitory factor). ,
immunocytochemical staining and mRNA expression of LIF and its receptor are consistent with the concept that LIF might be involved in growth initiation of primordial follicles through its receptor ,
At early human post-implantation stage, LIF is produced from decidua and chorionic villi and may exert its action on trophoblasts. Anembryonic pregnancy cannot be accounted for by defective expression of either LIF or LIF-Rbeta in most circumstances. ,
Both IL-6 and LIF can be very efficiently induced by IL-1beta in articular chondrocytes in vitro, more so in osteosarthritis than in normal cells. ,
LIFRbeta and the signaling subunit gp130 are expressed in hESCs and human LIF can induce STAT3 phosphorylation and nuclear translocation in hESCs. ,
LCH represents a cytokine-driven condition partially mediated by TNF, IL-11, and LIF. These three cytokines are all osteoclastogenic, suggesting a pathogenetic pathway for the osteolytic lesions in LCH. ,
These results indicated that LIF induced multi-lineage differentiation of adult stem-like cells in kidney via cadherin 16. ,
role of leukemia inhibitory factor (LIF) and its receptors in human embryo implantation ,
demonstrate using RNAi that Stat3 activation is necessary in the invasive phenotype of trophoblast cells and can be controlled via Leukemia Inhibitory Factor (LIF) ,
different members of the TGF-beta superfamily may also contribute in the reproductive process by enhancing endometrial proimplantatory LIF secretion and reducing proinflammatory IL-6 release by endometrial epithelium ,
LIF plays an essential role in the preimplantation embryo development and the blastocyst implantation and its gene mutations in women contribute to the implantation failure and subsequent infertility. ,
Data show that increased leukemia inhibitory factor secretion enhances airway reactivity and intracellular calcium signaling. ,
results suggest that the LIF gene mutations affect fertility ,
Since we demonstrated that not only SDF-1, but also HGF and LIF are upregulated in damaged tissues, we postulate that CXCR4+ c-Met+ LIF-R+ TCSC could be mobilized from the BM into the PB, where they play a role in tissue repair/regeneration. ,
Down-regulation of PRB in the endometrium is concomitant with the presence of glycodelin in the endometrium, suggesting interaction. ,
Suppressor of cytokine signaling-1 may prevent leukemia inhibitory factor signaling in human embryonic stem cells. ,
There is no receptivity defect with regard to LIF and IL-11 secretions by eutopic endometrium in infertile women with endometriosis. ,
Ciliary neurotrophic factor/LIF signaling pathway acts via regulation of nitric oxide production to modulate developmental programmed cell death of postmitotic rod precursor cells. ,
The regulation of LIF and its receptor (LIFR) expression in pancreatic carcinoma cells were studied. ,
provides a structural template to understand the formation and orientation of the high-affinity signaling complex between LIF, LIF receptor, and gp130 ,
interleukin-8 (CXCL-8) is induced by tumor necrosis factor-alpha and leukemia inhibitory factor in pancreatic carcinoma cells ,
CHROMOSOME
22,
ENTREZ_GENE_ID
3976 ,
UNIGENE
Hs.2250 ,
PIR_NREF_ID
NF00088240,
NF00135554,
UNIPROT_ID
LIF_HUMAN ,
Q52LZ2_HUMAN ,
CYTOBAND
22q12.2,
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