US 7,399,752 B2
High affinity nucleic acid ligands to lectins
David H. Parma, Boulder, Colo. (US); Brian Hicke, Boulder, Colo. (US); Philippe Bridonneau, Boulder, Colo. (US); and Larry Gold, Boulder, Colo. (US)
Assigned to Gilead Science, Inc., Foster City, Calif. (US)
Filed on Apr. 07, 2003, as Appl. No. 10/409,627.
Application 09/849928 is a division of application No. 08/952793, granted, now 6,280,932, previously published as PCT/US96/09455, filed on Jun. 05, 1996.
Application 10/409627 is a continuation of application No. 09/849928, filed on May 04, 2001, granted, now 6,544,959.
Application 08/952793 is a continuation in part of application No. 08/479724, filed on Jun. 07, 1995, granted, now 5,780,228.
Application 08/479724 is a continuation in part of application No. 08/472256, filed on Jun. 07, 1995, granted, now 6,001,988.
Application 08/472256 is a continuation in part of application No. 08/472255, filed on Jun. 07, 1995, granted, now 5,766,853.
Application 08/472255 is a continuation in part of application No. 08/477829, filed on Jun. 07, 1995, abandoned.
Application 08/477829 is a continuation in part of application No. 07/714131, filed on Jun. 10, 1991, granted, now 5,475,096.
Application 07/714131 is a continuation in part of application No. 07/536428, filed on Jun. 11, 1990, abandoned.
Prior Publication US 2004/0043923 A1, Mar. 04, 2004
Int. Cl. A61K 31/70 (2006.01); C07H 21/02 (2006.01); C07H 21/00 (2006.01); C12Q 1/68 (2006.01); C12P 19/34 (2006.01)
U.S. Cl. 514—44  [536/23.1; 536/25.3; 435/6; 435/91.2] 21 Claims
 
1. A method of inhibiting binding between L-selectin and a carbohydrate ligand of said L-selectin, comprising the step of contacting a nucleic acid ligand to said L-selectin with said L-selectin wherein said nucleic acid ligand to L-selectin is selected from the group consisting of SEQ ID NO: 67-117, 129-196, and 293-388.