Bani-Sadr F, Le Doussal L, Garand R, Billand E, Raffi F; International Conference on AIDS.

Int Conf AIDS. 1998; 12: 1159-60 (abstract no. 60871).

Hopital Raymond Poincare, Garches, France.

The large granular lymphocyte (LGL) proliferation is a relatively rare lymphoproliferative disorder of either T (CD3+) or natural killer (CD3-) lymphocytes. In non HIV-infected patients, T LGL is usually a clonal proliferation associated with neutropenia. OBJECTIVE: To describe the clinical and immunologic aspects of LGL proliferation in a monocentric cohort of HIV-1 infected patients. PATIENTS: Consecutive sample of 7 patients with increased numbers of LGL (> 1000/mm3) for more than 6 months. RESULTS: 5 Caucasian men and 2 African women (4 homosexuals, 2 heterosexuals and 1 drug addict) were studied. At diagnosis, the CDC stage was A2 in 2 patients, B1 in 1 patient, B3 in 2 patients and C in 2 patients. One patient had undergone splenectomy. The LGL proliferation was associated with persistent lymphocytosis (> 3000/mm3) in all cases and with neutropenia below 1500/mm3 in 5 cases. The LGL coexpress CD3 and CD8 but not CD16 in all cases. In 4 cases, DNA studies using TCR b and g probe showed no clonal rearrangement of T-cell receptor gene. The neutropenia was present before any therapy in 1 patient. The 4 others patients received potential neutropenic therapies such as cotrimoxazole and/or zidovudine. These ones were stopped in 3 cases without correction of neutropenia. The mean follow-up was 23 months. Bacterial infections occurred in 3 cases, sinusitis (n = 2) and pneumonia (n = 2). In 4 cases, the LGL count decreased parallel to the HIV viral load decrease under 2.6 log copies/ml. CONCLUSIONS: 1-Neutropenia may be secondary to LGL proliferation in HIV+ patients. 2-LGL were polyclonally expanded and their proliferation seemed to be correlate to HIV viral load.

Publication Types:

• Meeting Abstracts

Keywords:

• Acquired Immunodeficiency Syndrome
• Antigens, CD3
• Antigens, CD8
• Female
• HIV Infections
• HIV Seropositivity
• Humans
• Lymphocytes
• Lymphocytosis
• Male
• Neutropenia
• Receptors, Antigen, T-Cell
• Zidovudine
• immunology

Other ID:

• 98410487

UI: 102232816

From Meeting Abstracts