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Cognitive and Emotional Health Project: The Healthy Brain







Boston Naming Test (BNT)

MacArthur Studies of Successful Aging (Inouye et al. 1993; Berkman et al., 1993; Albert et al., 1995)

o Boston Naming Test; Delayed Recognition Span Test; Similarities; Figure copying; Delayed recall

Normative Aging Study (Jones KJ, Albert MS et al. 1991)

o Auditory & visual continuous performance tasks (Mirsky 1978); Boston Naming Test, Controlled Oral Word Association Test; Wechsler Memory Scale (memory for paragraphs, line drawings, paired associates); tests of delayed recall & recognition; Visual Reproductions subtest of WMS; clock drawing, clock copying; Gorham's Proverb Interpretation Test; Visual-Verbal Test; competing motor programs; Block Design subtest of WAIS, Digit Symbol Substitution Subtest of WAIS; Vocabulary subtest of WAIS.

Payton M et al. (1998) Relations of bone and blood lead to cognitive function: the VA Normative Aging Study.

Washington Heights, Northern Manhattan (Stern Y et al.1992)

o 1-hour test battery developed for use in this study: Orientation (10 orientation items from MMSE); Verbal reasoning (Similarities subtest of WAIS-R); Nonverbal reasoning (Identities and Oddities subtest of Mattis Dementia Rating Scale); Letter fluency (Controlled Word Association Test); Category fluency (animals, foods, clothing); Repetition (repeat high-frequency phrases from Boston Diagnostic Aphasia Examination Repetition of Phrases subtest); Auditory comprehension (first 6 items of Complex Ideational Material subtest of Boston Diagnostic Aphasia Examination); Word list learning and memory (Selective Reminding Test); Visuoperceptual skills (Figure matching - Benton Visual Retention Test); Nonverbal memory (multiple choice version of Benton Visual Retention Test); Visuoconstructional skills (Rosen Drawing Test); Attention (target-detection tasks).

o 2128 residents of Washington Heights in northern New York City were followed for 5 years, from 1991-1996. Dementia evaluations were also conducted. Patients who met criteria for probable or possible AD with a clinical dementia rating (CDR) scale score of 0.5 or higher were considered to have a clinical diagnosis of dementia.

Stricks L, Pittman J, Jacobs DM, Sano M, Stern Y. Normative data for a brief neuropsychological battery administered to English- and Spanish-speaking community-dwelling elders. J International Neuropsychological Society. 1998;4:311-8.

Romas SN, Mayeux R, Tang MX et al. (2000). No association between a presenilin 1 polymorphism and Alzheimer disease.

Devi G et al. (2000). Familial aggregation of Alzheimer disease among whites, African Americans, and Caribbean Hispanics in northern Manhattan.

Tang MX, Stern Y et al. (1998). The APOE-episilon4 allele and the risk of Alzheimer Disease among African Americans, White, and Hispanics.

Mayo AD Patient Registry (Petersen RC, Kokmen E et al. 1990)

o WAIS, WMS, Controlled Oral Word Association Test; Wide Range Achievement Test (WRAT); Free and Cued Selective Reminding Test; Auditory Verbal Learning Test (AVLT); Trail Making Test (TMT); Boston Naming Test (BNT); Multi-Lingual Aphasia Exam Token Test; Category Fluency Test (CFT); Mattis Dementia Rating Scale; MMSE; Short Test of Mental Status; Unified Parkinson's Disease Rating Scale; Hachinski Ischemic Scale; Dementia Rating Scale; Global Deterioration Scale

Petersen RC et al. (1999). Mild cognitive impairment: Clinical characterization and outcome.

Aging, Brain Imaging, and Cognition (Godfrey Pearlson MH60504, #35)

Community-based sample of 334 persons aged 20-96 followed from 1999-2004

"MMSE, TICS-m, NART-R, WAIS-R, TMT (Trail Making Test?), BTA, CPT, WCST (Wisconsin Card Sort Test), CET, HVLT-R, BVMT-R, WMS-R, PMT, RDT, BNT-30 (Boston Naming Test), verbal fluency, BFRT, CFT, pegboard, comparison speed."