Functionnal Organization of Somatosensory Responses in the Secondary Somatosensitive Area and Insula - Full Text View

Sponsored by:	Centre Hospitalier Universitaire de Saint Etienne
Information provided by:	Centre Hospitalier Universitaire de Saint Etienne
ClinicalTrials.gov Identifier:	NCT00542906

Purpose

The implication of the second somatosensory area (SII) and the insular cortex in the processing of somatosensory imputs is now well established. However the functionnal anatomy of these areas hidden in the depth of the sylvian scissure remain mostly unknown.

The aim of this fMRI study is to determine the functionnal cartography of SII and insula. The localization of responses to different somatosensory stimuli (slight touch, warm, cold, heat pain and arthrokinesia) applied on the left hand of 25 healthy volonteers, will be compared.

Condition	Intervention
Healthy	Other: localization

MedlinePlus related topics: Anatomy

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Treatment, Open Label, Single Group Assignment
Official Title:	Functionnal Organization of Somatosensory Responses in the Secondary Somatosensitive Area (SII) and Insula : an fMRI Study

Further study details as provided by Centre Hospitalier Universitaire de Saint Etienne:

Primary Outcome Measures:

Comparison of euclidian distances between the centroids of clusters activations for the different types of stimulations into SII and insula. [ Time Frame: one day ] [ Designated as safety issue: No ]

Secondary Outcome Measures:

Determine the Talairach coordinates of the centroids of clusters of activations for the different types of somatosensory stimuli into SII and insula [ Time Frame: one day ] [ Designated as safety issue: No ]

Estimated Enrollment:	25
Study Start Date:	October 2007
Estimated Study Completion Date:	March 2009
Primary Completion Date:	October 2007 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
1 healthy volunteers	Other: localization localization of the several types of somatosensory stimuli

Detailed Description:

Aims : Demonstrate that localization of the several types of somatosensory stimuli is different into SII and into insula. If possible, we'll determine a functionnal cartography of these areas.

Eligibility

Ages Eligible for Study:	18 Years to 50 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

25 healthy volonteers will be included ranging in age from 18 to 50 years
contraception needed for women
right handed
All the subjects have to give their written informed consent.

Exclusion Criteria:

pregnancy
neurological or psychiatric disease
drugs taken <12h before fMRI
contra-indications to fMRI : pacemaker, clip, metallic device
Refusing to be informed of the presence of a cerebral abnormality, detected during MRI.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00542906

Contacts

Contact: Laure Mazzola, MD

0033477127805

lauremazzola@yahoo.fr

Locations

France
Service de Neurologie - CHU de Saint-Etienne	Recruiting
Saint-Etienne, France, 42055
Contact: Laure Mazzola, MD 0033477127805 lauremazzola@yahoo.fr
Sub-Investigator: Roland PEYRON, MD PhD

Sponsors and Collaborators

Centre Hospitalier Universitaire de Saint Etienne

Investigators

Principal Investigator:

Laure Mazzola, MD

CHU de Saint-Etienne

More Information

Publications:

Mazzola L, Isnard J, Mauguiere F. Somatosensory and pain responses to stimulation of the second somatosensory area (SII) in humans. A comparison with SI and insular responses. Cereb Cortex. 2006 Jul;16(7):960-8. Epub 2005 Sep 21.

Peyron R, Schneider F, Faillenot I, Convers P, Barral FG, Garcia-Larrea L, Laurent B. An fMRI study of cortical representation of mechanical allodynia in patients with neuropathic pain. Neurology. 2004 Nov 23;63(10):1838-46.

Responsible Party:	Centre Hospitalier Universitaire de Saint Etienne ( Francoise LORCA )
Study ID Numbers:	0701023
Study First Received:	October 11, 2007
Last Updated:	June 4, 2008
ClinicalTrials.gov Identifier:	NCT00542906
Health Authority:	France: Direction Générale de la Santé

Keywords provided by Centre Hospitalier Universitaire de Saint Etienne:

healthy volunteers
Somatosensory stimuli
fMRI

second somatosensory area
insular cortex
functionnal anatomy

Study placed in the following topic categories:

Neoplasm Metastasis
Healthy

ClinicalTrials.gov processed this record on February 10, 2009