HARVARD MEDiCAL SCHDDL
THEDEPARTMENTOFPHARMACOLOGY
     i3S S"AlT"CK ST., RDSTON 16, YASS.

February 19, 1949

Dr. Joshua Lederberg
Department of Genetics
University of Wisconsin
College of Agriculture
Madison 6, Wisconsin

Dear Doctor Lederberg:

     I am ver;; sorry for the long delay in replying to your
letter of December 14.  Our secretary, who sent out the reprints
you requested, evidently misplaced the letter and only returned
it to me yesterday.

     The only treatment of Lineweaver-Burk equations of which
I am aware, that develops a unique statistical treatment occurs in
an addendum to an article in the Journal of Pharmacolom and Experimental
Therapeutics in the late 30's or early 40's.  I am sorry to say,
however, that I cannot locate the reference and have not had time
to thumb through the issues of those years to.Idiscover it again.
It impressed me on first reading because it was the only discussion
I had noticed that took serious account of the inadequacies of the
simple Lineweaver-Burk treatment and the difficulties of properly
weighting the points.

I am sorry I can not be more helpful.

Sincerely yours,

Avram Goldstein

P.S.  I have located the article in question and am afraid it is not,
after all, what you are after.  It is an Appendix by H.F. Dorn, to
the artic&e by C.18 Wight and J.C. Sabine in J.Pharm.Xxp.Thcrap.
78:  375. 1943.