	US 7,381,736 B2
	Thiazole and thiadiazole inhibitors of tyrosine phosphatases
Zacharia S. Cheruvallath, San Diego, Calif. (US); Colin J. Loweth, San Diego, Calif. (US); Ruth F. Nutt, Santa Fe, N. Mex. (US); Darryl Rideout, San Diego, Calif. (US); Joseph E. Semple, San Diego, Calif. (US); Jing Wang, San Diego, Calif. (US); Feiyue Wu, Poway, Calif. (US); Shankari Mylvaganam, San Diego, Calif. (US); Hengyi Zhu, San Diego, Calif. (US); and Jianzhong Sun, San Diego, Calif. (US)
Assigned to Metabasis Therapeutics, Inc., La Jolla, Calif. (US)
Filed on Sep. 02, 2005, as Appl. No. 11/219,402.
Claims priority of provisional application 60/642292, filed on Jan. 06, 2005.
Claims priority of provisional application 60/638447, filed on Dec. 22, 2004.
Claims priority of provisional application 60/607034, filed on Sep. 02, 2004.
Prior Publication US 2006/0194768 A1, Aug. 31, 2006
Int. Cl. A61K 31/427 (2006.01); C07D 277/18 (2006.01)

U.S. Cl. 514—370 [548/202; 548/193]

19 Claims

1. A compound that has formula II:

or a pharmaceutically acceptable salt, ester, enol ether, enol ester, solvate or hydrate thereof, wherein:

D is

E is CH₂;

s is 0;

R⁸and R⁹are H;

R¹⁰is halo;

R¹¹is halo;

R¹²is H;

R¹³is CF₂PO₃H₂;

R¹⁴is halo;

R¹⁵is H;

R¹⁶is NHC(O)COOH or COOH;

and

R¹⁷is COO-alkyl.