Allegre T, Cailleres S, Tadrist Z, Leprince Y, Jarry JM, Sault MC, Blanc AP; International Conference on AIDS.
Int Conf AIDS. 1994 Aug 7-12; 10: 175 (abstract no. PB0128).
Hopital Cezanne, Aix-en-provence, France.
Pulmonary lymphoma is rarely reported in AIDS patients. A 28 year old HIV infected male was admitted to the hospital with dyspnea, cough, and fever. He was intravenous drug user and his past history was remarkable for pneumocystis carini pneumonia; The CD4 positive cell count was 16/mm3.X-ray film of the chest showed multiple bilateral pulmonary nodules; Computed tomographic scan revealed also many lung nodules. Biopsy specimen was obtained by thoracoscopy and revealed a high grade polymorphic non Hodgkin's lymphoma of B cell type; the search of viral protein in the tumor showed existence of latent membrane proteins of Epstein Barr virus (EBV): LMP1 and EBNA2. Other radiological investigations, bone marrow biopsy were negative. Patient were treated with combined chemotherapy including adriamycin, cyclophosphamide, vincristine, methotrexate, and steroid, without success; he died ten months later after diagnosis of lymphoma. Lymphoma, the most prevalent HIV releated neoplasm after Kaposi's sarcoma, occurs in four to ten percent of patients with HIV disease, and .EBV seems to be associated in many cases. The most frequent sites after nodals involvement are: the central nervous system, the gastro intestinal tract, the liver and the bone marrow. Pulmonary involvement has been reported in less than ten percent of cases.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Biopsy
- HIV Infections
- HIV Seropositivity
- Herpesvirus 4, Human
- Humans
- Lung Neoplasms
- Lymphoma
- Lymphoma, B-Cell
- Lymphoma, Non-Hodgkin
- Male
- Pneumonia, Pneumocystis
Other ID:
UI: 102208396
From Meeting Abstracts