The Relative Importance of Factors Influencing Selenium Toxicity Joy A. Gober Abstract Selenium is the constituent most frequently identified as potentially impacting fish and wildlife species on irrigated lands in the States by the Department of Interior's National Irrigation Water Quality Program. Concentration of selenium is usually the first factor assessed. However, other factors should also be considered including the chemical form of selenium present, antagonism or synergism with other chemical constituents, substrate cation-exchange capacity, species sensitivity, exposure, dietary habits, behavior, age, vigor, water velocity, and temperature. In order to more effectively remediate for adverse impacts to fish and wildlife from selenium, accurate cause and effect relationships must be identified. A decision methodology that addresses the potential factors previously listed and guides the user toward the most appropriate focus is recommended. This approach might prove useful for potential future remediation sites and help ensure the most effective use of time, effort, and money. KEY TERMS: Selenium; irrigation drainage; biota.