FOTHERGILL AW, RINALDI MG, SCHWOCHO LR, OHYA S; Interscience Conference on Antimicrobial Agents and Chemotherapy (41st : 2001 : Chicago, Ill.).

Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 2001 Dec 16-19; 41: abstract no. J-822.

University of Texas Health Science Center, San Antonio, TX

BACKGROUND: New azole antimycotics continue to reach the market, many with the promise of increased activity over those agents that are currently available. In an effort to evaluate the new azole CS-758 (formerly R-120758, SAN - Sankyo), we compared its activity to that of amphotericin B (AMB - Bristol Myers Squibb), fluconazole (FLU - Pfizer), and itraconazole (ITRA - Janssen). METHODS: A total of 250 isolates were tested to include 150 systemic fungi, 12 zygomycetes, 48 hyalohyphomycetes, 25 phaeohyphomycetes, and 15 dermatophytes. All were clinical isolates submitted to the FTL for evaluation. Susceptibility testing was accomplished according to the methods outlined in the NCCLS document, M38-P. The minimum inhibitory concentration (MIC) was defined as the lowest concentration that resulted in an 80% reduction in turbidity as compared to a drug-free control tube for azoles and 100% inhibition for AMB. RESULTS: SAN consistently had MICs lower than the other agents tested. Geometric mean MICs for the hyalohyphomycetes such as Paecilomyces lilacinus and Fusarium spp. were AMB 4.5 microg/ml, FLU 101.6 microg/ml, ITRA 4.2 microg/ml, and SAN 0.5 microg/ml. Scedosporium spp., notoriously resistant, gave similar results with AMB 11.3 microg/ml, FLU 35.9 microg/ml, ITRA 2.0 microg/ml, and SAN 0.29 microg/ml. Those for the systemic fungi were impressive with AMB 0.2 microg/ml, FLU 10 microg/ml, ITRA 0.06 microg/ml, and SAN 0.007 microg/ml. CONCLUSION: The new azole, SAN, proves to be an active agent against the mould fungi. Further studies are warranted to determine if activity seen in vitro is indicative of activity in vivo. This being the case, this agent may prove to provide therapy options for refractory infections.

Publication Types:

• Meeting Abstracts

Keywords:

• Amphotericin B
• Arthrodermataceae
• Fluconazole
• Fungi
• In Vitro
• Itraconazole
• Microbial Sensitivity Tests
• R-120758
• Triazoles

Other ID:

• GWAIDS0029112

UI: 102268744

From Meeting Abstracts