DAVID: Database for Annotation, Visualization, and Integrated Discovery (Laboratory of Immunopathogenesis and Bioinformatics (LIB); National Institute of Allergies and Infectious Diseases (NIAID); Science Applications International Corporation (SAIC)

SP_COMMENT

PTM:N-glycosylated., PTM:The soluble form derives from the membrane form by proteolytic processing., disease:Defects in FASLG are the cause of autoimmune lymphoproliferative syndrome type 1B (ALPS1B) [MIM:601859]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly., function:Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects., similarity:Belongs to the tumor necrosis factor family., subcellular location:Cell membrane; Single-pass type II membrane protein. Secreted. Note=May be released into the extracellular fluid, probably by cleavage form the cell surface., subunit:Homotrimer.,

ENTREZ_GENE_SUMMARY

The protein encoded by this gene is the ligand for FAS. Both are transmembrane proteins. Interaction of FAS with this ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE).,

GENE_SYMBOL

FASLG,

GENERIF_SUMMARY

Mouse cells expressing human membrane-bound, but not soluble, Fas ligand induce inflammation in vivo., Expression of FasL gene in T cells of renal allograft recipients, Differential secretion of Fas ligand microvesicles during activation-induced death of T cells, Induction of FasL expression by adhesion of endometrial stromal cells to the extracellular matrix may take part in the development of immunotolerance by inducing apoptosis of cytotoxic T lymphocytes, Western blot analysis showed that butyrate increased Fas and Fas ligand levels in butyrate-induced apoptosis., Expression of Fas and Fas ligand in esophageal tissue mucosa and carcinomas, A minimal region of the fasL promoter has been identified containing the transcription start site and a noncanonical c-Myc-binding element, which mediates fasL promoter repression by the activated vitamin D3 receptor in T lymphocytes., expression was found mainly on astrocytes and microglial cells; no significant difference between cases with and without pontosubicular neuron necrosis, Up-regulation in highly malignant multiple myeloma plasma cells negatively regulates erythroblast maturation; a major pathogenetic mechanism of anemia in multiple myeloma., evaluation of the FasL gene FASL on chromosome 1q23 as a candidate susceptibility gene for Type I diabetes, The results indicate that FasL inhibition by all-trans-RA involves a novel mechanism whereby the transcriptional function of NFAT is blocked., Fas/FasL pathway can be employed by monocytes/macrophages to induce VSMC apoptosis in the atherosclerotic lesions., upregulation of Fas by IFN-gamma in SNU-638 may accelerate the apoptosis pathway through the Fas and FasL interaction between gastric cancer cells and immune cells, physiological function of human sFasL is to delete the potentially auto-reactive "memory" lymphocytes, HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas ligand promoter, FasL protein is an important mediator of apoptosis., Differential expressions of Fas and Fas ligand in human placenta, Genetic polymorphisms of FasL (CD178) in human longevity, Ets-1 and Sp1 have a role in regulating FasL expression in human vascular smooth muscle cells, The endometrial cells expressed Fas and low levels of FasL, expressed during acute cellular rejection episodes after kidney transplantation, "trophoblast-cytokine-Fas/FasL triad" determines the ability of the Fas/FasL system to regulate trophoblast viability, Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles., Abnormal expression and function of Fas ligand of lachrymal glands and peripheral blood was found in Sjogren's syndrome patients with enlarged exocrine glands., findings support the hypothesis that the expression of FasL in normal ovary is hormonally sensitive, the role of Fas/Fas ligand (FasL) in tum orgenesis, immune escape, counterattack in colonic cancer, Regulation of fas ligand expression by IL-8 in human endometrium., inhibiton of CD95L expression by vitamin E, serum and peritoneal fluid of women with moderate to severe endometriosis contain elevated concentrations of soluble Fas ligand compared to women with minimal or mild endometriosis and women without endometriosis, tranduces, in synergy with non-cytotoxic anti-Fas monoclonal antibody (mAb), signals for apoptosis and nuclear translocation of the NF-kappaB (p65/p50) heterodimer, fas ligand is up-regulated in acute lung injury and the acute respiratory distress syndrome, The human papillomavirus type 16 E5 protein impairs TRAIL- and FasL-mediated apoptosis in HaCaT cells by different mechanisms., T cells from systemic lupus erythematosus patients kill autologous monocytes through apoptotic pathways involving the ligand FasL., In transgenic mice, the human FASL promoter induces reporter expression in intestinal epithelial cells. Non-lymphoid FasL is expressed in response to peripheral T cell activation & regulates T cells that infiltrate peripheral tissues., Cleavage of FasL by MMP-7 occurs at the leucine residues in sequence "ELAELR" within the region between the transmembrane and trimerization domains. When this site is unavailable, a "SL," is cleaved. MMP-7 differentially processes murine and human FasL, homeostatic regulation of myelopoiesis in bone marrow is mediated via an autoregulatory feedback loop via the Fas-FasL pathway, A role for the Fas/Fas ligand apoptotic pathway in regulating myeloid progenitor cell kinetics., Somatostatin receptor subtype 2 sensitizes human pancreatic cancer cells to ligand-induced apoptosis, The Fas ligand may be involved in the apoptosis of astrocytic tumors, and the apoptotic index can be a useful parameter for assessing prognosis of astrocytic tumors., expression and function of fas ligand in human myeloid leukemia cells, Fas-L expression may be associated with the escape from of immunal surveillance., Fas system as an inducer of apoptosis in cutaneous leishmaniasis, To see if variants of the FasL gene played a role in Hashimoto's thyroiditis and Graves' disease, 2 FasL polymorphisms (C -843 T in the promoter, A IVS2nt-124 G in intron 2)were studied. No association was found., Bax, Bcl-2, fas and Fas-L antigen expression in human seminoma, Through the high and sustained expression of FasL that is transcriptionally regulated, synovial gamma delta T cells of the V delta 1 subtype may efficiently lyse a wide variety of cell types at sites of inflammation., An AP-1 site located in the 5' untranslated region of the CD95L gene is required for TCR/CD3-mediated induction of the human CD95L promoter., Cross-talk between glioma cells and neutrophils through the Fas/FasL system stimulated expression of IL-6 and IL-8 in glioma cells, enhanced neutrophil viability, and stimulated cytokine production in neutrophils., JNK/p38 > c-Jun > Fas ligand > Fas pathway plays an important role in mediating cisplatin-induced apoptosis in ovarian cancer cells, expression and function in human urinary bladder transitional cell carcinomas; correlates with tumor progression, results showed that Fas and/or Fas-Ligand, Bcl-2, and tissue transglutaminase may be involved in apoptotic pathways leading to mucosal atrophy in children with coeliac disease, cytokine-induced trophoblast apoptosis is mediated in part by the FasL/Fas pathway, suggesting that cytokines promote sensitivity to Fas-mediated apoptosis, Toxic epidermal necrolysis and Stevens-Johnson syndrome are induced by this protein., apoptosis mediated by Fas-FasL and engagement of CTLA-4 are involved in modulation of the immune response in patients infected with Paracoccidioides brasiliensis, Longitudinal data indicate that FasL mRNA increases in peripheral blood mononuclear cells of multiple sclerosis (MS) patients, especially during the secondary progressive course, and is downregulated during clinical activity in relapsing remitting MS., Fas-FasL interactions may contribute to mechanisms of neuronal loss and neuritic degeneration in Alzheimer disease., ATG-induced apoptosis in T cells involves both Fas and TNF pathways and TNF-alpha is produced much earlier than Fas and FasL expression., Lethal cytokines, such as FasL, may contribute to peritoneal cell turnover and the loss of mesothelium in peritoneal dialysis., CTLA4-FasL fusion protein inhibits the primary mixed leukocyte reaction (MLR), induces specific hyporesponsiveness in the secondary MLR, and may potentially induce hyporesponsiveness by promoting both anergy and apoptosis of alloresponsive clones., Fas/Fas-L and Bcl-2 expression participate in regulation of apoptosis in extravillous trophoblast(EVT) along invasion to decidua. Increased apoptosis in invasive phenotype of EVT may be attributable to increased Fas and Fas-L and decreased Bcl-2., Fas ligand increases Kv1.3 channel activity through the same canonical apoptotic signaling cascade that is required for potassium efflux, cell shrinkage, and apoptosis, apoptosis by FasL-dependent ligation is not modulated by Bcl-2 in vivo, FasL is implicated in differentiation, growth, invasion and metastasis of gastric cancer by inducing apoptosis of infiltrating lymphocytes., Data suggest that increased intrathecal release of Fas, but not FasL or caspase 3, in the cerebrospinal fluid of infants with hydrocephalus may serve as an indicator of brain injury from progressive ventricular dilatation., Levels in CSF are elevated in in neuro-Behcet's disease., induction of CD95/CD95L expression does not have a role in p53-induced apoptosis, Modulation of FasL by placental as well as maternal hormonal milieu induces apoptosis in decidual cells, glandular cells, and immune cells, facilitating trophoblast invasion and peritrophoblastic immunotolerance., Fas ligand is not constitutively expressed in normal peripheral blood or neoplastic B lymphocytes, Data show that Fas ligand is expressed on cytotoxic effector and memory cells, suggesting that the Fas/FasL system is involved in the inflammatory process observed in silicosis patients., Progesterone-induced apoptosis in immortalized normal and malignant HOSE cells involves enhanced expression of FASL., These results support a role for Egr-1, -2, and -3 in nonlymphoid expression of Fas ligand, TRAIL, and tumor necrosis factor., hepatitis C virus core protein plays a role in the induction of functional FasL in a hepatoblastoma cell line, Fas and Fas ligand expression in leukocytes during systemic inflammation, As brief as a >10-min exposure of human T cells to fibronectin-associated recombinant FasL induces T cell activation and potentiates proinflammatory capacities, e.g., adhesion to extracellular matrix, IFN-gamma secretion, and retention in inflamed areas., FasL blocks expression of CD28 at the transcriptional level, expression of CD95 in 15/17 human melanoma cell lines analysed, but complete lack of CD95 ligand (CD95L), expression levels in hepatocellular carcinoma, compard with HBxAg levels, activated langerhan's cells are capable of expressing CD95-L in a functional location, thus bearing the potential to exert tolerogenic capabilities against CD95-expressing T cells, This review considers the role of the FasL-Fas system as a double-edged sword in the central nervous system, NF-kappaB activation and FasL overexpression occur in PBMCs and atherosclerotic lesions of patients with carotid stenosis. The NF-kappaB-FasL pathway could be involved in the mechanisms underlying plaque instability in humans, The observed impact of FasL on adhesion and transendothelial migration provides evidence for novel biological functions of FasL., Fas engagement with Fas ligand induced activation of Akt and upregulation of endothelial nitric oxide synthase expression without induction of apoptosis., Fas and FasL have roles in progression of breast cancer, CD95L derived from placenta acts systemically and is primary cause of liver damage in HELLP syndrome. Blocking CD95L can reduce liver cell apoptosis. Strategy may have therapeutic advantages., examined the correlation between injury of the hepatocytes and mRNA expression of FasL and perforin/granzyme B in liver tissue to investigate the roles of both the FasL and the perforin/granzyme B pathways in chronic hepatitis B, The sensitivity of FasL expressing tumor cells to lysis by cytotoxic T-cells was similar to that of FasL non-expressors, To evaluate the impact of genetic variations to apoptosis during progression of acquired immunodeficiency syndrome (AIDS), we have performed an extensive genetic analysis of Fas and Fas ligand ( FasL) genes., Results show that FasL in endometrial stromal cells in culture has a cyclic expression model, suggesting that there may be a regulation at the translation level., FASL secretion was analyzed in melanoma cells in culture. The secretion was associated with secretory vesicles upon melanoma activation with phytohemagglutonins or alpha-MSH., Significantly lower soluble form of fas is associated with bile duct carcinoma, fasL gene expression is induced by Hepatitis B virus X protein through enhancing transcriptional activity of Egr-2 and Egr-3, The function of endothelial FasL during atherosclerosis was studied in APOE(-) mice transgenic for human FasL. Overexpression of endothelial FasL is antiinflammatory and inhibits atherosclerosis under hypercholesterolemic conditions., The frequent expression and coexpression of Fas, FasL, and c-FLIP in urothelial carcinomas implicates c-FLIP as an inhibitor of the Fas-FasL-induced death pathway in these tumors., addition of IL-12 might increase the efficacy of IL-2 immunotherapy by inhibition of the IL-10-mediated negative feed-back loop on IL-2-mediated sFasL release, CD95L, which is found elevated in many human cancer patients, has tumorigenic activities on human cancer cells, Cardiomyocyte necrosis and/or apoptosis via activated tumor necrosis factor (TNF) and the Fas/Fas ligand (FasL) system may be related to the development of ongoing myocardial damage., serum sFasL in biliary disease may be derived predominantly from activated immune cells and not from cancer cells, High levels of Max and stress-induced NFkappaB activation may result in elevated expression of Fas ligand in human lung cancer cells and possibly contribute to Fas ligand-associated immune escape mechanisms., FasL protein levels show that C57BL/10 cortical cultures are more resistant to death receptor-mediated apoptotic cell death as compared to C57BL/6 strain mice., FasL induces NF-kappaB activation and IL-8 production by a novel mechanism, distinct from that of TNF-alpha, CD95 and/or DR5 can induce apoptosis of CD40-activated chronic lymphocytic leukemia cells, Data report that antagonism of the type 1 insulin-like growth factor receptor in combination with inhibitors of the epidermal growth factor receptor synergistically sensitizes human malignant glioma cells to CD95L-induced apoptosis., sFasL may be involved in either induction of apoptosis or autoimmune diseases., upregulation of mesangial FasL may contribute to the glomerular inflammation in proliferative lupus nephritis, A lymphoproliferative disorder could be associated with mutation in this ligand., activation of p38 MAPK and c-Jun N-terminal kinase pathways by hepatitis B virus X protein mediates apoptosis via induction of Fas/FasL and TNFR1/TNFa expression, Fas and TRAIL play an important role in the H. pylori-mediated apoptosis of gastric epithelial cells., FasL is produced by and stored in the first trimester human syncytiotrophoblasts only and they lack surface membranal FasL., Supernatants from T cell blasts, pulse-stimulated with phytohemagglutinin contained FasL expressed on microvesicles ., Heart graft biopsies haveelevated FasL mRNA expression levels compared to the expression levels before and after acute rejection, results suggest that p21 and FasL gene activation is required for myeloid leukemia cell survival or maturation but not for cell death via Sp1 and NFkappaB as regulators of these genes, Effect of hibuscus polyphenol extracs in human gastric carcinoma cells is mediated via p53 signaling and p38 MAPK/FasL cascade pathway., The extracellular domains of FasL are sufficient to drive membrane FasL-induced formation of supramolecular Fas-FasL complexes, whereas soluble FasL-induced Fas aggregation is dependent on lipid rafts and the intracellular domain of Fas., Serum levels may be affected by insulin resistance, but is not an effective markers of silent myocardial ischemia in type 2 diabetes., FasL-mediated cytotoxicity is regulated by the FasL cytoplasmic tail, Cutaneous T cell lymphoma cells express functional FasL possibly contributing to bystander cytotoxicity within tumor infiltrates., The data suggest that lower expression of surface Fas, but higher levels of apoptosis-inhibiting sFas, contribute to the resistance of fibroblasts in lung fibrosis against apoptosis., Fas ligand is an apoptotic pathway of hepatocellular carcinoma cells., membrane-associated FasL is pro-apoptotic, whereas mFasL can be released from T lymphocytes., We evaluate a family with 4 of its 5 members harboring a mutation causing skipping of exon-6; ALPS in one male patient was caused by haploinsufficiency of membrane CD95 expression. Our data challenge the hypothesis that sCD95 causes autoimmunity, a linear pathway for Nef-induced FasL expression that encompasses p38 and AP-1 has been elucidated. Furthermore, chemical inhibition of the p38 pathway attenuates HIV-1-mediated bystander killing of CD8 cells in vitro, FASL polymorphisms contribute to susceptibility of lung cancer., The expression of FasL is upregulated in colon cancer and the functionally expressed FasL can induce apoptosis of Fas-expressing T lymphocytes., Up-regulation of FasL expression plays an important role in invasive depth, histological classification and metastasis of gallbladder carcinoma., NF-kappaB may regulate Fas-mediated apoptosis in HIVAN by controlling the expression of Fas ligand in renal epithelium, sFasL and matrilysin are expressed in seminal plasma and have a role in regulation of the function of the Fas system, The FasL expressed in human colon cancer cells may be regulated by endogenous factors in the microenvironment of the host and facilitate the escape of tumor cells from the host immune system., Data strongly indicate that an increment of soluble FAS/soluble FASL ratio after treatment could be an excellent marker of chemosensitivity in colorectal cancer., FASL expression on tumor-derived exosomes is required for induction of T-cell apoptosis, which appears to be a novel mechanism of tumor immune evasion., Plasma levels may be a marker for chronic hepatitis C infections., During tuberculosis, predisposition of CD4 T-cell subsets to apoptosis may involve both low expression of Bcl-2 and excessive expression of Fas ligand (FasL)., the trans-activation ability of Tat at the long terminal repeat does not correlate with T cell apoptosis but that the ability of Tat to up-regulate CD178 mRNA expression and induce apoptosis in T cells is critically dependent on the C terminus of Tat, Our data indicate an associaton between premature rupture of membranes and increased prevalence of neonatal AG genotype at -670 Fas promoter gene., results suggest that hepatitis C virus and Fas ligand play a key role in hepatocarcinogenesis, The combination of some polymorphisms of Fas or FasL significantly influenced CD4+ T cell production and viral load decrease, showing that these genes can play a role in the immunoreconstitution triggered by antiretroviral therapy., the intracellular Fas ligand (FasL) domain binding to the adaptor protein PSTPIP results in a cytoplasmic localization of FasL, These results indicate that aplastic anemia T cells are "preactivated", characterized by overexpression of FasL, especially intracellular FasL which can be stimulated to release in bioactive exosomes-bound form., Colon cancer cells can escape the immune surveillance and killing via decreasing Fas expression, and can counterattack the immune system via increasing FasL expression, FasL is recruited into lipid rafts for maximum Fas receptor contact and cell death-inducing potency, The FasLigand expression was up-regulated during acute kidney traft rejection episodes., Treatment of melanoma lines with soluble Fas ligand resulted in programmed cell death that was proportional to the pre-existing levels of surface Fas., FCH/SH3 proteins might play an important role for the subcellular distribution and lysosomal association of FasL., a novel fusion protein, designated scFvCD7, Localization to lipid rafts appears to be predominantly mediated by the characteristic cytoplasmic proline-rich domain of Fas ligand., thymosin beta-4 increases colon carcinoma apoptosis resistance triggered by FasL and apoptosis inhibitors by downregulating Fas and upregulating Survivin expression, Fas downregulation and a consequential increased resistance to FasL-triggered apoptosis resulting from upregulated MMP-7 in colorectal cancer cells could be a key mechanism for their escape from the immune surveillance, Data obtained demonstrate that the combination of arsenite with inhibitors of COX-2 may affect the target cancer cells via induction of FasL-mediated death signaling., A marked up-regulation of TLR2 and Fas-FasL was detected in primary human gingival epithelial cells (HGEC) stimulated with heat-killed P. gingivalis, FAS and FASLG polymorphisms appear to jointly contribute to risk of bladder cancer in the southern Chinese population., Genetic variants in the FAS and FASLG gene may contribute to the etiology of melanoma in the general population, particularly in those with a low risk of sunlight-induced melanoma., FasL-associated adaptor protein Nck is involved in the actin-dependent transport of FasL-bearing secretory lysosomes to the mimunological synapse., chromatin remodeling is a primary event in the activation of TNFSF6 expression in primary and leukemia T cells, angiostatins K1-3, K1-4 and K1-4.5 mediate anti-angiogenesis in a process involvingp53, FasL, AKT and mRNA deregulation, Study concludes that polymorphisms of FASL and FAS associate with type II diabetes and estimates of insulin resistance in Danish white subjects., findings show that deletion of primary thymocytes and Thy278 cells upon CD3 stimulation is considerably impaired by neutralizing CD95L antibody, The glucocorticoid receptor down-regulates fasL promoter by competing with NFkappaB for binding to the common response element., Fas/FasL-mediated signaling pathways play crucial roles in apoptotic disturbances of T cell subsets, especially of CD4+ T cells from systemic lupus erythematosus patients with active disease., Our findings identify a novel proinflammatory role of FasL in keratinocytes that is independent of caspase activity and is separable from apoptosis., most CD4(+)CD25(+)FOXP3(+) T cells found in cord blood are naive and exhibit low CD95 expression. Furthermore, most of these newborn T(regs) are not sensitive toward CD95L similar to naive T(regs) from adult individuals., Thus, m-CD95L expressing APC might be used in clinical settings to obtain tolerance induction in allogeneic transplantation systems or autoimmune diseases., sFas, sFas-L, and MMP-3, which were significantly elevated in sera of active untreated AOSD patients and paralleled disease activity, may be involved in the pathogenesis of this disease, Fas and FasL serum concentrations in patients coinfected with HIV and HCV indicate programmed cell death., Epithelial cell apoptosis and associated upregulation of Fas and apoptotic Fas pathway genes in epithelial cells of lungs with bleomycin-induced fibrosis., Thus, our work unveils that Fas ligand-mediated apoptosis induces scrambling of mitochondrial and secretory organelles via a global alteration of membrane traffic that is modulated by apical caspases., These results suggest that the FAS-1377G>A and -670A>G and FASL-844C>T polymorphisms do not significantly affect the susceptibility to lung cancer in Koreans., sFas concentrations are increased and sFasL are decreased in subjects at high cardiovascular risk, suggesting that these proteins may be novel markers of vascular injury., We found that signaling through CD62L up-regulated FasL., These results suggest that apoptosis triggered by the release of soluble FasL from invading trophoblasts contributes to the loss of smooth muscle from the walls of spiral arteries during pregnancy., Pemphigus vulgaris patient IgG works together with Fas-L and tumor necrosis factor-alpha in experimental cell cultures to induce acantholysis via basal cell shrinkage., The data demonstrated that HIV-1 Tat enhances C. parvum-induced cholangiocyte apoptosis via a paracrine-mediated, FasL-dependent mechanism., expression of FasL is upregulated in testes of patients with Sertoli cell-only syndrome & maturation arrest, suggesting that it may be associated with apoptotic elimination or altered maturation of Fas-expressing germ cells by activation of caspase-3., Significantly high Fas Ligand Protein is associated with aggressive NK-cell leukemia, interaction between membrane-bound hyaluronan and the cell surface CD44 was involved in the up-regulation of FasL expression on T cells and subsequent activation-induced cell death, phosphorylation and ubiquitin signals regulate the sorting of FasL to secretory lysosomes by controlling entry into multivesicular bodies, Treatment with oleandrin facilitated nuclear translocation of FKHR in human, but not murine cells by dephosphorylating Akt., These findings indicate that functional polymorphisms in FAS and FASL contribute to increased apoptosis of tumor infiltration lymphocytes and risk of breast cancer., These findings suggest that ADAM10 represents an important molecular modulator of FasL-mediated cell death., results indicate that the -844C > T polymorphism is not related with the susceptibility to hepatitis C virus infection, the severity of liver damage and the progression of fibrosis in our cohort of Spanish patients, FasL CC genotype was found to increase the risk of ovarian carcinoma and a protective effect of the GGCT genotype was observed, Germ-line functional polymorphisms affecting either the levels of expression or the biological activity of both Fas and FasL genes could be contributing to the genetic risk to develop T-cell lymphoblastic lymphomas., ADAM10 and SPPL2a were identified as two proteases implicated in FasL processing and release of the FasL intracellular domain, which has been shown to be important for retrograde FasL signaling, The frequent expression and coexpression of Fas, FasL and c-FLIP in colorectal carcinoma implicates c-FLIP as an inhibitor of the Fas-FasL-induced death pathway in these tumours., The serum levels of soluble FASL were studied in patients with multiple organ failure with complicating peritonitis., Fas/FasL gene polymorphysms are possible that different mechanisms function in apoptosis balance in papillary thyroid cancer development, heterozygous human FasL mutation can dominantly interfere with normal FasL apoptotic function and lead to an ALPS phenotype, designated Type Ib, FasL expression was associated with higher tumour stage., Serum level of FASL was determined during chemotherapy of lung neoplasms., The FAS-1377, FAS-670, and FASL-844 polymorphisms were not found to be markers of melanoma risk., Allografted cells undergo Fas-mediated apoptosis induced by CD8+ T cells. Our objective was to prevent human keratinocytes from immunologically induced apoptosis by blocking the Fas ligand/Fas interaction.,

ENTREZ_GENE_ID

356,

PIR_NREF_ID

NF00091774, NF00125290, NF00129194,

CYTOBAND

1q23,