Energy Citations Database

Bibliographic Citation

 
Document
For copies of Journal Articles, please contact the Publisher or your local public or university library and refer to the information in the Resource Relation field.
For copies of other documents, please see the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or Document Availability.
Title Recovery of glucose metabolism in reperfused canine myocardium demonstrated by positron-CT (PCT)
Creator/Author Schwaiger, M. ; Sochor, H. ; Parodi, O. ; Grover, M. ; Hansen, H.W. ; Selin, C. ; Schelbert, H.R.
Publication Date1984 Jan 01
OSTI IdentifierOSTI ID: 6438119
Report Number(s)CONF-840619-
Other Number(s)CODEN: JNMEA
Resource TypeConference
Specific TypeJournal Article
Resource RelationJ. Nucl. Med. ; Vol/Issue: 25:5; 31. annual meeting of the Society of Nuclear Medicine; 5 Jun 1984; Los Angeles, CA, USA
Research OrgUCLA School of Medicine, Los Angeles, CA
Subject550501 -- Metabolism-- Tracer Techniques ;560162 -- Radionuclide Effects, Kinetics, & Toxicology-- Animals, Plants, Microorganisms, & Cells ;551001 -- Physiological Systems-- Tracer Techniques; FLUORODEOXYGLUCOSE-- TISSUE DISTRIBUTION;FLUORODEOXYGLUCOSE-- UPTAKE;MYOCARDIUM-- METABOLISM;MYOCARDIUM-- POSITRON COMPUTED TOMOGRAPHY; ANAEROBIC CONDITIONS;BIOLOGICAL RECOVERY;DOGS;DYNAMIC FUNCTION STUDIES;RADIOPHARMACEUTICALS;TRACER TECHNIQUES
Related SubjectANIMALS;ANTIMETABOLITES;BODY;CARDIOVASCULAR SYSTEM;COMPUTERIZED TOMOGRAPHY;DIAGNOSTIC TECHNIQUES;DISTRIBUTION;DRUGS;EMISSION COMPUTED TOMOGRAPHY;HEART;ISOTOPE APPLICATIONS;LABELLED COMPOUNDS;MAMMALS;MUSCLES;ORGANS;RECOVERY;TOMOGRAPHY;VERTEBRATES
Description/Abstract The authors previously examined with PCT in chronic dogs the long term metabolic recovery during reperfusion after a 3 hr ischemic insult.^ Increased regional glucose utilization at 24 hrs of R accurately identified reversible tissue injury documented by late improvement in segmental function by ultrasonic crystals.^ To define the early metabolic events after a 3 hr LAD balloon occlusion, regional blood flow and glucose utilization was studied in 8 dogs with PCT, N-13 ammonia (NA) and F-18 deoxyglucose (FDG) at 2 hrs and at 24 hrs after R.^ The dogs were then thoracotomized and MBF by microspheres, arterio-venous differences for glucose, lactate and O/sub 2/ across the reperfused segment (LAD vein) and the left ventricle (coronary sinus) measured.^ Immediately after reperfusion, MBF and FDG uptake were 27 +- 24% and 21 +- 48% lower in the reperfused territory (RT) than in control myocardium (C).^ At 24 hrs, MBF by microspheres was and 22 +- 25% lower and FDG uptake 175 +- 73% higher in RT than in C. In the RT, consumption of glucose (by Fick method) was 202 +- 107% higher, of lactate 96 +- 85% lower and of O/sub 2/ 42 +- 26% lower than in the entire LV.^ PCT measured FDG uptake correlated with glucose consumption (r=0.94) and confirmed that the segmentally increased FDG uptake at 24 hrs reflected increased glucose utilization that, as indicated by the reduced lactate consumption, was partly anaerobic.^The authors conclude that initially after R, glucose metabolism is depressed but increases above C within 24 hrs, a time course that now can be determined noninvasively with PCT and is useful for predicting functional recovery.
Country of PublicationUnited States
LanguageEnglish
FormatPages: 37
System Entry Date2001 May 13

Top