Bibliographic Citation
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Title | Recovery of glucose metabolism in reperfused canine myocardium demonstrated by positron-CT (PCT) |
Creator/Author | Schwaiger, M. ; Sochor, H. ; Parodi, O. ; Grover, M. ; Hansen, H.W. ; Selin, C. ; Schelbert, H.R. |
Publication Date | 1984 Jan 01 |
OSTI Identifier | OSTI ID: 6438119 |
Report Number(s) | CONF-840619- |
Other Number(s) | CODEN: JNMEA |
Resource Type | Conference |
Specific Type | Journal Article |
Resource Relation | J. Nucl. Med. ; Vol/Issue: 25:5; 31. annual meeting of the Society of Nuclear Medicine; 5 Jun 1984; Los Angeles, CA, USA |
Research Org | UCLA School of Medicine, Los Angeles, CA |
Subject | 550501 -- Metabolism-- Tracer Techniques ;560162 -- Radionuclide Effects, Kinetics, & Toxicology-- Animals, Plants, Microorganisms, & Cells ;551001 -- Physiological Systems-- Tracer Techniques; FLUORODEOXYGLUCOSE-- TISSUE DISTRIBUTION;FLUORODEOXYGLUCOSE-- UPTAKE;MYOCARDIUM-- METABOLISM;MYOCARDIUM-- POSITRON COMPUTED TOMOGRAPHY; ANAEROBIC CONDITIONS;BIOLOGICAL RECOVERY;DOGS;DYNAMIC FUNCTION STUDIES;RADIOPHARMACEUTICALS;TRACER TECHNIQUES |
Related Subject | ANIMALS;ANTIMETABOLITES;BODY;CARDIOVASCULAR SYSTEM;COMPUTERIZED TOMOGRAPHY;DIAGNOSTIC TECHNIQUES;DISTRIBUTION;DRUGS;EMISSION COMPUTED TOMOGRAPHY;HEART;ISOTOPE APPLICATIONS;LABELLED COMPOUNDS;MAMMALS;MUSCLES;ORGANS;RECOVERY;TOMOGRAPHY;VERTEBRATES |
Description/Abstract | The authors previously examined with PCT in chronic dogs the long term metabolic recovery during reperfusion after a 3 hr ischemic insult.^ Increased regional glucose utilization at 24 hrs of R accurately identified reversible tissue injury documented by late improvement in segmental function by ultrasonic crystals.^ To define the early metabolic events after a 3 hr LAD balloon occlusion, regional blood flow and glucose utilization was studied in 8 dogs with PCT, N-13 ammonia (NA) and F-18 deoxyglucose (FDG) at 2 hrs and at 24 hrs after R.^ The dogs were then thoracotomized and MBF by microspheres, arterio-venous differences for glucose, lactate and O/sub 2/ across the reperfused segment (LAD vein) and the left ventricle (coronary sinus) measured.^ Immediately after reperfusion, MBF and FDG uptake were 27 +- 24% and 21 +- 48% lower in the reperfused territory (RT) than in control myocardium (C).^ At 24 hrs, MBF by microspheres was and 22 +- 25% lower and FDG uptake 175 +- 73% higher in RT than in C. In the RT, consumption of glucose (by Fick method) was 202 +- 107% higher, of lactate 96 +- 85% lower and of O/sub 2/ 42 +- 26% lower than in the entire LV.^ PCT measured FDG uptake correlated with glucose consumption (r=0.94) and confirmed that the segmentally increased FDG uptake at 24 hrs reflected increased glucose utilization that, as indicated by the reduced lactate consumption, was partly anaerobic.^The authors conclude that initially after R, glucose metabolism is depressed but increases above C within 24 hrs, a time course that now can be determined noninvasively with PCT and is useful for predicting functional recovery. |
Country of Publication | United States |
Language | English |
Format | Pages: 37 |
System Entry Date | 2001 May 13 |
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