	US 7,399,795 B2
	Surface modification of contact lenses
Yu-Chin Lai, Pittsford, N.Y. (US); and Edmond T. Quinn, Rochester, N.Y. (US)
Assigned to Bausch & Lomb Incorporated, Rochester, N.Y. (US)
Filed on May 30, 2006, as Appl. No. 11/442,826.
Application 11/442826 is a continuation of application No. 10/728531, filed on Dec. 05, 2003, granted, now 7,084,188.
Prior Publication US 2006/0217454 A1, Sep. 28, 2006
Int. Cl. C08F 290/96 (2006.01); G02C 7/04 (2006.01)

U.S. Cl. 523—107 [523/106; 424/422; 351/160 H]

6 Claims

1. A surface modified medical device comprising:

a medical device manufactured from a monomer mixture containing 20 to 80 weight % of at least one prepolymer selected from the group consisting of reactive functionalized fumaric or itaconic-containing polymeric compounds having the following formula:

YCO—CH═CHCOW(R₁)_n(SiR₂R₃O)_m(SiR₂R₃)(R₁)_nWOCCH═CH—COY

and

CH₂═C(CH₂COY)COW(R₁)_n(SiR₂R₃O)_m(SiR₂R₃) (R₁)_nWOC(CH₂COY)C═CH₂

wherein R₁is selected from the group consisting of alkylenes and alkylenes containing ether linkages, R₂and R₃are independently selected from the group consisting of alkyl groups, phenyl groups, alkyl groups substituted with halogen, phenyl groups substituted with halogen, alkyl groups containing ether linkages and phenyl groups containing ether linkages, W is O or NH, n is an integer between 1 and 10, m is an integer between 2 and 200, and Y is a residue having a reactive functional group selected from the group consisting of hydroxyl, carboxyl, oxazolone, epoxy and anhydride functional groups; and

one or more reactive, hydrophilic polymers applied to the surface of said medical device;

whereby a chemical reaction between said reactive functionalized famaric- or itaconic-containing polymeric material and said one or more reactive, hydrophilic polymers forms covalent bonds therebetween.