Bibliographic Citation
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Title | The sunburn cell in hairless mouse epidermis: quantitative studies with UV-A radiation and mono- and bifunctional psoralens |
Creator/Author | Young, A.R. ; Magnus, I.A. |
Publication Date | 1982 Oct 01 |
OSTI Identifier | OSTI ID: 6561869 |
Other Number(s) | CODEN: JIDEA |
Resource Type | Journal Article |
Resource Relation | J. Invest. Dermatol. ; Vol/Issue: 79:4 |
Research Org | Department of Photobiology, Institute of Dermatology, London, England |
Subject | 560121 -- Radiation Effects on Cells-- External Source-- (-1987); ;EPIDERMIS-- BIOLOGICAL RADIATION EFFECTS;PSORALEN-- RADIOSENSITIVITY EFFECTS; BIOLOGICAL PATHWAYS;DOSE-RESPONSE RELATIONSHIPS;MICE;RADIATION DOSES;ULTRAVIOLET RADIATION |
Related Subject | ANIMAL TISSUES;ANIMALS;ANTICOAGULANTS;BIOLOGICAL EFFECTS;BODY;COUMARINS;DOSES;DRUGS;ELECTROMAGNETIC RADIATION;EPITHELIUM;HEMATOLOGIC AGENTS;HETEROCYCLIC COMPOUNDS;MAMMALS;ORGANIC COMPOUNDS;ORGANIC OXYGEN COMPOUNDS;ORGANS;RADIATION EFFECTS;RADIATIONS;RODENTS;SKIN;TISSUES;VERTEBRATES |
Description/Abstract | The production of the sunburn cell by UV-A radiation and topical psoralens in hairless mouse epidermis has been studied.^It has been shown that the appearance of this cell is dependent on the dose of both UV-A radiation and of the psoralen.^The time-course with 8-methoxypsoralen has peak sunburn cell numbers at 28 hr postirradiation.^A comparison of 2 bifunctional (8-methoxypsoralen and 5-methoxypsoralen) and 2 monofunctional (angelicin and 3-carbethoxypsoralen) psoralens showed the former are more potent.^This suggests that DNA crosslink lesions may play a rle in sunburn cell production. |
Country of Publication | United States |
Language | English |
Format | Pages: 218-221 |
System Entry Date | 2001 May 13 |
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