Energy Citations Database

Bibliographic Citation

 
Document
For copies of Journal Articles, please contact the Publisher or your local public or university library and refer to the information in the Resource Relation field.
For copies of other documents, please see the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or Document Availability.
Title The sunburn cell in hairless mouse epidermis: quantitative studies with UV-A radiation and mono- and bifunctional psoralens
Creator/Author Young, A.R. ; Magnus, I.A.
Publication Date1982 Oct 01
OSTI IdentifierOSTI ID: 6561869
Other Number(s)CODEN: JIDEA
Resource TypeJournal Article
Resource RelationJ. Invest. Dermatol. ; Vol/Issue: 79:4
Research OrgDepartment of Photobiology, Institute of Dermatology, London, England
Subject560121 -- Radiation Effects on Cells-- External Source-- (-1987); ;EPIDERMIS-- BIOLOGICAL RADIATION EFFECTS;PSORALEN-- RADIOSENSITIVITY EFFECTS; BIOLOGICAL PATHWAYS;DOSE-RESPONSE RELATIONSHIPS;MICE;RADIATION DOSES;ULTRAVIOLET RADIATION
Related SubjectANIMAL TISSUES;ANIMALS;ANTICOAGULANTS;BIOLOGICAL EFFECTS;BODY;COUMARINS;DOSES;DRUGS;ELECTROMAGNETIC RADIATION;EPITHELIUM;HEMATOLOGIC AGENTS;HETEROCYCLIC COMPOUNDS;MAMMALS;ORGANIC COMPOUNDS;ORGANIC OXYGEN COMPOUNDS;ORGANS;RADIATION EFFECTS;RADIATIONS;RODENTS;SKIN;TISSUES;VERTEBRATES
Description/Abstract The production of the sunburn cell by UV-A radiation and topical psoralens in hairless mouse epidermis has been studied.^It has been shown that the appearance of this cell is dependent on the dose of both UV-A radiation and of the psoralen.^The time-course with 8-methoxypsoralen has peak sunburn cell numbers at 28 hr postirradiation.^A comparison of 2 bifunctional (8-methoxypsoralen and 5-methoxypsoralen) and 2 monofunctional (angelicin and 3-carbethoxypsoralen) psoralens showed the former are more potent.^This suggests that DNA crosslink lesions may play a rle in sunburn cell production.
Country of PublicationUnited States
LanguageEnglish
FormatPages: 218-221
System Entry Date2001 May 13

Top