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Section 1: Groundwork, 1 1 The Excitement of Developmental Biology, 3 Where the subject came from, 3 Central position in biology, 3 Impact on society, 4 Future impact, 4 2 General Problems of Development, 6 Nuclear totipotency, cloning of animals, 7 3 Key Molecular Components, 10 Genes, 10 Signalling systems, 13 Cytoskeleton, 16 Cell adhesion molecules, 18 Appendix,19 Transcription factor families, 19 Inducing factor families, 20 Cell adhesion molecules, 24 Extracellular matrix components, 25 4 Common Features of Development, 27 Gametogenesis, 27 Fertilization, 30 Early development, 30 Morphogenetic processes, 35 Evolution of developmental mechanisms,41 5 Developmental Genetics, 48 Developmental mutants, 48 Screening for mutants, 53 Cloning of genes, 55 Transgenesis, 55 Limitations of developmental genetics, 57 6 Experimental Embryology, 60 Normal development, 60 Developmental commitment, 63 Acquisition of commitment, 66 Homeotic genes, 68 7 Techniques for the Study of Development, 73 Microscopy, 73 Study of gene expression by biochemical methods, 76 In situ methods, 79 Microinjection, 81 Cell-labelling methods, 83 Reporter genes, 84 Section 2: Major Model Organisms, 87 8 Model Organisms, 89 Availability and cost, 89 Access and micromanipulation, 90 Genetics and genome maps, 90 Relevance, 91 9 Xenopus,93 Oogenesis, maturation, fertilization, 93 Embryonic development, 94 Experimental methods, 100 Regional specification, 103 Inductive interactions, 108 10 TheZebrafish, 116 Normal development, 116 Mutagenesis, 117 Regional specification, 120 11 The Chick, 122 Normal development, 123 Regional specification of the early embryo, 129 Description of organogenesis in the chick, 131 12 The Mouse, 140 Normal development, 140 Technology of mouse development, 149 Regional specification in development, 158 Other topics in mouse development, 162 13 Drosophila,165 Insects, 165 Normal development, 166 Drosophila developmental genetics, 169 Overview of the developmental program, 173 The dorsoventral pattern, 174 The anteroposterior system, 178 14 Caenorhabditis elegans, 191 Normal development, 191 Regional specification in the embryo, 193 Analysis of postembryonic development, 198 Programmed cell death, 200 Section 3: Organogenesis and Regeneration, 205 15 Tissues, 207 Epithelial tissues, 207 Connective tissues, 207 Muscle, 209 Neural tissues, 209 Blood and blood vessels, 209 16 Development of the Nervous System, 212 Overall structure and cell types, 212 Anteroposterior patterning of the neural plate, 216 Dorsoventral patterning of the neural tube, 219 Neurogenesis and gliogenesis, 220 The neural crest, 224 Development of neuronal connectivity 227 17 Development of Mesodermal Organs, 236 Somitogenesis, 236 The kidney, 242 Gonadal development, 245 Limb development, 250 18 Drosophila Imaginal Discs, 262 Metamorphosis, 262 Genetic study of larval development, 262 Mitotic recombination, 264 Disc development, 268 Regional patterning of the wing disc, 272 Regional patterning of the leg disc, 275 19 Stem Cells and Tissue Growth, 278 Size and proportion, 278 Renewal tissues, 279 Growth in stature, 288 Postnatal disorders of growth and differentiation, 291 Cancer, 291 20 Regeneration of Missing Parts, 296 Distribution of regenerative capacity, 296 Planarian regeneration, 297 Vertebrate limb regeneration, 300