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Title Structural analysis of complementary DNA and amino acid sequences of human and rat androgen receptors
Creator/Author Chang, C. ; Kokontis, J. ; Liao, S. (Univ. of Chicago, IL (USA))
Publication Date1988 Oct 01
OSTI IdentifierOSTI ID: 5546989
Other Number(s)ISSN0027-8424; CODEN: PNASA
Resource TypeJournal Article
Resource RelationProceedings of the National Academy of Sciences of the United States of America ; Vol/Issue: 85:19
Subject550201 -- Biochemistry-- Tracer Techniques; MESSENGER-RNA-- HYBRIDIZATION;RECEPTORS-- AMINO ACID SEQUENCE;RECOMBINANT DNA-- MOLECULAR STRUCTURE; ANDROGENS;CYSTEINE;ELECTROPHORESIS;GENES;GLUCOCORTICOIDS;MAN;METHIONINE;RATS;SULFUR 35;TRITIUM COMPOUNDS
Related SubjectADRENAL HORMONES;AMINO ACIDS;ANDROSTANES;ANIMALS;BETA DECAY RADIOISOTOPES;BETA-MINUS DECAY RADIOISOTOPES;CARBOXYLIC ACIDS;CORTICOSTEROIDS;DAYS LIVING RADIOISOTOPES;DNA;DRUGS;EVEN-ODD NUCLEI;HORMONES;HYDROGEN COMPOUNDS;HYDROXY COMPOUNDS;ISOTOPES;KETONES;LIGHT NUCLEI;LIPOTROPIC FACTORS;MAMMALS;MEMBRANE PROTEINS;MOLECULAR STRUCTURE;NUCLEI;NUCLEIC ACIDS;ORGANIC ACIDS;ORGANIC COMPOUNDS;ORGANIC SULFUR COMPOUNDS;PREGNANES;PRIMATES;PROTEINS;RADIOISOTOPES;RNA;RODENTS;STEROID HORMONES;STEROIDS;SULFUR ISOTOPES;THIOLS;VERTEBRATES
Description/Abstract Structural analysis of cDNAs for human and rat androgen receptors (ARs) indicates that the amino-terminal regions of ARs are rich in oligo- and poly(amino acid) motifs as in some homeotic genes.^The human AR has a long stretch of repeated glycines, whereas rat AR has a long stretch of glutamines.^There is a considerable sequence similarity among ARs and the receptors for glucocorticoids, progestins, and mineralocorticoids within the steroid-binding domains.^The cysteine-rich DNA-binding domains are well conserved.^Translation of mRNA transcribed from AR cDNAs yielded 94- and 76-kDa proteins and smaller forms that bind to DNA and have high affinity toward androgens.^These rat or human ARs were recognized by human autoantibodies to natural Ars.^Molecular hybridization studies, using AR cDNAs as probes, indicated that the ventral prostate and other male accessory organs are rich in AR mRNA and that the production of AR mRNA in the target organs may be autoregulated by androgens.
Country of PublicationUnited States
LanguageEnglish
FormatPages: 7211-7215
System Entry Date2001 May 13

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