Table of Contents
PPT Slide
PPT Slide
Diabetic Neuropathy
Myelinated Neuron
PNS Anatomy
Diabetic Peripheral Nerve Damage
Neuropathic Symptoms and Signs
PNS Anatomy
Neuropathic Symptoms
Neuropathic Signs
Diabetic Peripheral Neuropathy
San Antonio Consensus Statement
DCCT Design
DCCT Neurological Outcome
PPT Slide
Aldose Reductase and Alcar Trials
Sural Nerve Biopsies in Man
Axon Counts in Human Sural Nerves
Axon Loss in Diabetic Neuropathy
Aldose Reductase: Zenerstat
Change in NCS: Sural and Composite with Zenarestat
Change in Nerve fiber Density with Zenarestat
Zenarestat Increases the MNFD for Small Myelinated Fibers
Aldose Reductase: Zenerstat Phase III Trial
Nerve Growth Factor
PPT Slide
Change in the Lower Limb NIS With NGF
Changes in CDT and HPT in the hNGF-Diabetic Neuropathy Study
Nerve Growth Factor Phase III
Measures in Current and Proposed Trials
Measures in Current and Proposed Trials
Clinical Endpoints
Entry Criteria
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