LOCUS       CAA57767                 361 aa            linear   PRI 07-OCT-2008
DEFINITION  Brain 4 [Homo sapiens].
ACCESSION   CAA57767
VERSION     CAA57767.1  GI:732756
DBSOURCE    embl accession X82324.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1
  AUTHORS   de Kok,Y.J., van der Maarel,S.M., Bitner-Glindzicz,M., Huber,I.,
            Monaco,A.P., Malcolm,S., Pembrey,M.E., Ropers,H.H. and Cremers,F.P.
  TITLE     Association between X-linked mixed deafness and mutations in the
            POU domain gene POU3F4
  JOURNAL   Science 267 (5198), 685-688 (1995)
   PUBMED   7839145
REFERENCE   2  (residues 1 to 361)
  AUTHORS   Cremers,F.P.M.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-JUL-1994) F.P.M. Cremers, Human Genetics Dept,
            University Hospital Nijmegen, PO Box 9101, 6500 HB Nijmegen,
            NETHERLANDS
FEATURES             Location/Qualifiers
     source          1..361
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq21.1"
                     /tissue_type="brain"
                     /dev_stage="fetal"
     Protein         1..361
                     /name="Brain 4"
     Region          186..260
                     /region_name="Pou"
                     /note="Pou domain - N-terminal to homeobox domain;
                     cl02582"
                     /db_xref="CDD:121419"
     Region          279..336
                     /region_name="homeodomain"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; cd00086"
                     /db_xref="CDD:28970"
     Site            order(279..283,285,302,308,321,323..324,327..328,330..332,
                     334..335)
                     /site_type="DNA binding"
                     /db_xref="CDD:28970"
     Site            order(281,284,324,327..328,331)
                     /site_type="other"
                     /note="specific DNA base contacts"
                     /db_xref="CDD:28970"
     CDS             1..361
                     /standard_name="Brain 4"
                     /coded_by="X82324.1:33..1118"
                     /db_xref="GDB:351386"
                     /db_xref="GOA:P49335"
                     /db_xref="HGNC:9217"
                     /db_xref="HSSP:P14859"
                     /db_xref="InterPro:IPR000327"
                     /db_xref="InterPro:IPR001356"
                     /db_xref="InterPro:IPR012287"
                     /db_xref="InterPro:IPR013847"
                     /db_xref="InterPro:IPR016362"
                     /db_xref="UniProtKB/Swiss-Prot:P49335"
ORIGIN      
        1 mataasnpys ilsstslvha dsagmqqgsp frnpqkllqs dylqgvpsng hplghhwvts
       61 lsdggpwsst latspldqqd vkpgredlql gaiihhrsph vahhsphtnh pnawgaspap
      121 npsitssgqp lnvysqpgft vsgmlehggl tpppaaasaq slhpvlrepp dhgelgshhc
      181 qdhsdeetpt sdeleqfakq fkqrriklgf tqadvglalg tlygnvfsqt ticrfealql
      241 sfknmcklkp llnkwleead sstgsptsid kiaaqgrkrk krtsievsvk gvlethflkc
      301 pkpaaqeiss ladslqleke vvrvwfcnrr qkekrmtppg dqqphevysh tvktdtschd
      361 l
//