Inhibition of growth of the dimorphic fungus Paracoccidioides brasiliensis by ajoene.

Antimicrob Agents Chemother. 1989 September; 33(9): 1641–1644.

PMCID: PMC172723

G San-Blas, F San-Blas, F Gil, L Mariño, and R Apitz-Castro

Centro de Microbiología y Biología Celular, Instituto Venezolano de Investigaciones Científicas, Carcas, Venezuela.

This article has been cited by other articles in PMC.

Abstract

Ajoene, a garlic-derived compound that prevents platelet activation, inhibited the growth of Paracoccidioides brasiliensis, a fungal pathogen for humans, by affecting the integrity of the fungal cytoplasmic membrane. This action may be the basis for the study of ajoene as a possible specific antifungal drug.

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Selected References

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