Home Inroduction/Background Opening Remarks State of the Research Advocates' Remarks Recommendations and Findings Closing Remarks Appendices


APPENDIX IX: DES BIBLIOGRAPHY*(Selected References)

DIETHYLSTILBESTROL BIBLIOGRAPHY:
KEY REFERENCES PUBLISHED PRIOR TO 1993


Ablin RJ, Bartkus JM, Gonder MJ. In vitro effects of diethylstilbestrol and the LHRH analogue leuprolide on natural killer cell activity. Immunopharmacology 15:95-101, 1988

Dieckmann WJ, Davis ME, Rynkiwwicz LM, Pottinger RE. Does the administration of diethylstilbestrol during pregnancy have therapeutic value? Am J Obstet Gynecol 66:1062-1081, 1953

Dodds EC, Goldberg L, Lawson W, Robinson R. Estrogenic activity of certain synthetic compounds. Nature 141:247-248, 1938

FDA Drug Bulletin: Diethylstilbestrol Contraindicated in Pregnancy. Washington, DC: U.S. Department of Health, Education and Welfare (DHEW), 1971

Fink DJ: DES Task Force Summary Report. Washington, D.C.: Government Printing Office (DHEW publication No. NIH 79-1688), 1978

Greenwald P, Barlow JJ, Nasca PC, Burnett WS. Vaginal cancer after maternal treatment with synthetic estrogens. N Engl J Med 285:390-392, 1971

Herbst AL. Clear cell adenocarcinoma and the current status of DES-exposed females. Cancer 48:484-488, 1981

Herbst AL, Anderson S, Hubby MM, Haenszel WM, Kaufman RH, Noller KL. Risk factors for the development of diethylstilbestrol-associated clear cell adenocarcinoma: A case-control study. Am J Obstet Gynecol 154:814-822, 1986 (Comment in Am J Obstet Gynecol 172:1651-1652, 1995)

Herbst AL, Scully RE. Adenocarcinoma of the vagina in adolescence. A report of seven cases including six clear cell carcinomas (so-called mesonephromas). Cancer 25:745-757, 1970

Herbst AL, Ulfelder H, Poskanzer DC. Adenocarcinoma of the vagina: Association of maternal stilbestrol therapy with tumor appearance in young women. N Engl J Med 284:878-881, 1971

Kalland T, Campbell T. Effects of diethylstilbestrol on human natural killer cells in vitro. Immunopharmacology 8:19-25, 1984

Kaufman RH, Adam E, Noller KL, Irwin JF, Gray M. Upper genital tract changes and infertility in diethylstilbestrol-exposed women. Am J Obstet Gynecol 154:1312-1318, 1986

Melnick S, Cole P, Anderson D, Herbst AL. Rates and risks of diethylstilbestrol-related clear cell adenocarcinoma of the vagina and cervix. N Engl J Med 316:514-516, 1987

Noller KL, Blair PB, O'Brien PC, Melton LJ III, Offord JR, Kaufman RH, Colton T. Increased occurrence of autoimmune disease among women exposed in utero to diethylstilbestrol. Fertil Steril 49:1080-1082, 1988

Report of the 1985 DES Task Force. U.S. Office of the Assistant Secretary of Health. Bethesda, MD: U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, 1987

Robboy SJ, Noller KL, O'Brien, P, Kaufman RH, Townsend D, Barnes AB, Gundersen J, Lawrence D, Bergstrahl E, McGorray S, Tilley B, Anton J, Chazen G. Increased incidence of cervical and vaginal dysplasia in 3,980 diethylstilbestrol-exposed young women. Experience of the National Collaborative Diethylstilbestrol Adenosis Project. JAMA 252:2979-2983, 1984

Robboy SJ, Szyfelbein WM, Goellner JR, Kaufman RH, Taft PD, Richart RM, Gaffey TA, Prat J, Virata R, Hatab PA, McGorray SP, Noller KL, Townsend D, Labarthe D, Barnes AB. Dysplasia and cytologic findings in 4,589 young women enrolled in the Diethylstilbestrol-Adenosis (DESAD) Project. Am J Obstet Gynecol 140:579-586, 1981

Smith OW, Smith GV. The influence of diethylstilbestrol on the progress and outcome of pregnancy as based on a comparison of treated with untreated primagravidas. Am J Obstet Gynecol 56:994-1000,1948

Ways SC, Mortola JF, Zvaifler NJ, Weiss RJ, Yen SS. Alterations in immune responsiveness in women exposed to diethylstilbestrol in utero. Fertil Steril 48:193-197, 1987

Wingard DL, Turiel J. Long-term effects of exposure to diethylstilbestrol. West J Med 149:551- 554, 1988

DIETHYLSTILBESTROL BIBLIOGRAPHY: 1993-1999

1993

Baldini E, Gardin G, Naso C, Pronzato P, Rosso R, Rubagotti A, et al. Stimulation of human breast cancer in vivo. Experimental findings and clinical results. Ann N Y Acad Sci 698:418-422, 1993

Berendes HW, Lee YJ. Suspended judgment. The 1953 clinical trial of diethylstilbestrol during pregnancy: Could it have stopped DES use? Control Clin Trials 14:179-182, 1993

Buitendijk SE, Verloove-Vanhorick SP. DES and preterm birth rate. Paediatr Perinat Epidemiol 7:223-224, 1993

Colton T, Greenberg ER, Noller K, Resseguie L, Van Bennekom C, Heeren T, et al. Breast cancer in mothers prescribed diethylstilbestrol in pregnancy. Further follow-up. JAMA 269:2096-2100, 1993

Diethylstilbestrol as a model for environmental estrogens. Environ Health Perspect 101:111, 1993

Fleming AD, Anderson TL. Cervical AV malformation with in utero DES exposure. Nebr Med J 78:138-139, 1993

Holladay SD, Baylock BL, Comment CE, Heindel JJ, Fox WM, Korach KS, Luster MI. Selective prothymocyte targeting by prenatal diethylstilbestrol exposure. Cell Immunol 152:131-142, 1993

Kostrzewska A, Laudanski T, Batra S. Effect of ovarian steroids and diethylstilbestrol on the contractile responses of the human myometrium and intramyometrial arteries. Eur J Pharmacol233:127-134, 1993

Levine RU, Berkowitz KM. Conservative management and pregnancy outcome in diethylstilbestrol-exposed women with and without gross genital tract abnormalities. Am J Obstet Gynecol 169:1125-1129, 1993

Malone KE. Diethylstilbestrol (DES) and breast cancer. Epidemiol Rev 15:108-109, 1993

Merchant WJ, Gale J. Intestinal metaplasia in stilboestrol-induced vaginal adenosis. Histopathology 23:373-376, 1993

Nagel TC, Malo JW. Hysteroscopic metroplasty in the diethylstilbestrol-exposed uterus and similar nonfusion anomalies: Effects on subsequent reproductive performance; a preliminary report. Fertil Steril 59:502-506, 1993

Newbold RR. Gender-related behavior in women exposed prenatally to diethylstilbestrol. Environ Health Perspect 101:208-213, 1993

Noller KL. Role of colposcopy in the examination of diethylstilbestrol-exposed women. Obstet Gynecol Clin North Am 20:165-176, 1993

Palmlund I, Apfel R, Buitendijk S, Cabau A, Forsberg JG. Effects of diethylstilbestrol (DES) medication during pregnancy: Report from a symposium at the 10th international congress of ISPOG. J Psychosom Obstet Gynaecol 14:71-89, 1993

Pillard RC, Rosen LR, Meyer-Bahlburg H, Weinrich JD, Feldman JF, Gruen R, et al. Psychopathology and social functioning in men prenatally exposed to diethylstilbestrol (DES). Psychosom Med 55:485-491, 1993

Seoud MA, Tawfik O, Hunter V. Peritoneal papillary serous carcinoma in a woman with a history of utero DES exposure. Gynecol Oncol 50:371-373, 1993

Seymour L, Meyer K, Bezwoda WR. Hormone priming in breast cancer: Oestrogen priming has a detrimental effect on response in oestrogen receptor-negative patients. Eur J Cancer 29A:1495-1496, 1993

Sharpe RM, Skakkebaek NE. Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract? Lancet 341:1392-1395, 1993

1994

Bergmann KE, Wooge CH, Carlson KE, Katzenellenbogen BS, Katzenellenbogen JA. Bivalent ligands as probes of estrogen receptor action. J Steroid Biochem Molec Biol 49:139-152, 1994

Biing JT, Yang YF, Liu HS, Ye CT, Chao CF. The induction of multidrug resistance in human cervical carcinoma cell lines by estrogenic hormones. Proc Natl Sci Counc Repub China B 18:64-70, 1994

Bishop MC. Treatment of advanced prostate cancer [comment]. Lancet 343:110-111, 1994 (Comment on Lancet 342:901-905, 1994)

Diethylstilbestrol. ACOG Committee Opinion: Committee on Gynecologic Practice. Number 131-December 1993. Int J Gynaecol Obstet 44:184, 1994

Emens JM. Continuing problems with diethylstilboestrol. Br J Obstet Gynaecol 101:748-750, 1994

Hornsby PP, Wilcox AJ, Weinberg CR, Herbst AL. Effects on the menstrual cycle of in utero exposure to diethylstilbestrol. Am J Obstet Gynecol 170:709-715, 1994

Mittendorf R, Herbst AL. DES exposure: An update. Contemp Pediatr 11:59-62, 64, 66, 1994

Santti R, Newbold RR, Makela S, Pylkkanen L, McLachlan JA. Developmental estrogenization and prostatic neoplasia. Prostate 24:67-78, 1994

Schachter SC. Handedness in women with intrauterine exposure to diethylstilbestrol. Neuropsychologia 32:619-623, 1994

Waggoner SE, Mittendorf R, Biney N, Anderson D, Herbst AL. Influence of in utero diethylstilbestrol exposure on the prognosis and biologic behavior of vaginal clear-cell adenocarcinoma. Gynecol Onco 55:238-244, 1994

1995

Assies J, Vonk J, Bleker O, Lumey L. Diethylstilbestrol (DES)-related endocrine disturbances in women. A story with no end, yet. Ann N Y Acad Sci 761:369-372, 1995

Bell SE, Apfel RJ. Looking at bodies: Insights and inquiries about DES-related cancer. Qual Sociology 18:3-19, 1995

Castelbaum AJ, Sawin SW, Bellardo LJ, Lessey BA. Endometrial integrin expression in women exposed to diethylstilbestrol in utero. Fertil Steril 63:1217-1221, 1995

Chalmers I. Dangers of overviews of health care. Lancet 346:1038-1039, 1995

DeMars LR, Van Le L, Huang I, Fowler WC. Primary non-clear-cell adenocarcinomas of the vagina in older DES-exposed women. Gynecol Oncol 58:389-392, 1995

Fox R, Barry C. Stilboestrol exposure in utero and risk of pre-eclampsia. Lancet 345:800, 1995

Giusti RM, Iwamoto K, Hatch EE. Diethylstilbestrol revisited: A review of the long-term health effects. Ann Intern Med 122:778-788, 1995

Hornsby PP, Wilcox AJ, Herbst AL. Onset of menopause in women exposed to diethylstilbestrol in utero. Am J Obstet Gynecol 172(1 Pt 1):92-95, 1995

Jongbloet PH, Hanselaar AG, Bernheim JL. Clear cell adenocarcinoma associated with diethylstilbestrol: "Overripeness ovopathy" as a risk or causal factor? Am J Obstet Gynecol 172:1651-1652, 1995

Macarthur C, Foran PJ, Bailar JC III. Qualitative assessment of studies included in a meta-analysis: DES and the risk of pregnancy loss. J Clin Epidemiol 48:739-747, 1995

Migliaccio S, Newbold RR, McLachlan, JA, Korach KS. Alterations in estrogen levels during development affects the skeleton: Use of an animal model. Environ Health Perspect 103 (Suppl 7):95-97, 1995

Mittendorf R, Williams MA. Stilboestrol exposure in utero and risk of pre-eclampsia. Lancet 345:265-266, 1995

Mittendorf R. Teratogen update: Carcinogenesis and teratogenesis associated with exposure to diethylstilbestrol (DES) in utero. Teratology 51:435-445, 1995

Newbold R. Cellular and molecular effects of developmental exposure to diethylstilbestrol: Implications for other environmental estrogens. Environ Health Perspect 103(Suppl 7):83-87, 1995

Palmlund I. Dangers of overviews of health care. Lancet 346:852-853, 1995

Roy D, Pathak DN. Histone nuclear proteins are irreversibly modified by reactive metabolites of diethylstilbestrol. J Toxicol Environ 44:449-459, 1995

Scheirs JG, Vingerhoets AJ. Handedness and other laterality indices in women prenatally exposed to DES. J Clin Exp Neuropsychol 17:725-730, 1995

Smith PH. Hormone therapy: An overview. Cancer Surv 23:171-181, 1995

Sundaram B. Tackling the aftermath faced by the daughters of DES. Nurs Times 91:34-35, 1995

Walker BE, Kurth LA. Multi-generational carcinogenesis from diethylstilbestrol investigated by blastocyst transfers in mice. Int J Cancer 61:249-252, 1995

Wilcox AJ, Umbach DM, Hornsby PP, Herbst AL. Age at menarche among diethylstilbestrol granddaughters. Am J Obstet Gynecol 173(3 Pt 1):835-836, 1995

Wilcox AJ, Baird DD, Weinberg CR, Hornsby PP, Herbst AL. Fertility in men exposed prenatally to diethylstilbestrol. N Engl J Med 332:1411-1416, 1995

Yonemura CY, Cunha GR, Sugimura Y, Mee SL. Temporal and spatial factors in diethylstilbestrol-induced squamous metaplasia in the developing human prostate. II. Persistent changes after removal of diethylstilbestrol. Acta Anat (Basel) 153:1-11, 1995 1996

Baird DD, Wilcox AJ, Herbst AL. Self-reported allergy, infection, and autoimmune diseases among men and women exposed in utero to diethylstilbestrol. J Clin Epidemiol 49:263-266, 1996

Bekker MH, Heck GL, Vingerhoets AJ. Gender-identity, body-experience, sexuality, and the wish for having children in DES-daughters. Women's Health 24:65-82, 1996

Boyd J, Takahashi H, Waggoner SE, Jones LA, Hajek RA, Wharton JT, et al. Molecular genetic analysis of clear cell adenocarcinomas of the vagina and cervix associated and unassociated with diethylstilbestrol exposure in utero. Cancer 77:507-513, 1996

Cahen F, Dubreuil E, Pons JC. Prenatal exposure to diethylstilbestrol and the mother-daughter relationship. Eur J Obstet Gynecol Reprod Biol 65:181-187, 1996

Calle EE, Mervis CA, Thun MJ, Rodriguez C, Wingo PA, Heath CW Jr. Diethylstilbestrol and risk of fatal breast cancer in a prospective cohort of US women. Am J Epidemiol 144:645-652, 1996

Gray K, Bullock B, Dickson R, Raszmann K, Walmer D, McLachlan J, et al. Potentiation of diethylstilbestrol-induced alterations in the female mouse reproductive tract by transforming growth factor-alpha transgene expression. Molec Carcinog 17:163-173, 1996

Hall J. Teratogen update: Diethylstilbestrol. Growth Genet Horm 12:46, 1996

Hines M, Sandberg EC. Sexual differentiation of cognitive abilities in women exposed to diethylstilbestrol (DES) prenatally. Horm Behav 30:354-563, 1996

Huckell C, Laskin J, Gelmon K. Premenopausal breast cancer after in-utero exposure to stilboestrol. Lancet 348:331, 1996

Ismail RS, Okawara Y, Fryer JN, Vanderhyden BC. Hormonal regulation of the ligand for c-kit in the rat ovary and its effects on spontaneous oocyte meiotic maturation. Molec Reprod Dev 43:458-469, 1996

Kipersztok S, Javitt M, Hill MC, Stillman RJ. Comparison of magnetic resonance imaging and transvaginal ultrasonography with hysterosalpingography in the evaluation of women exposed to diethylstilbestrol. J Reprod Med 41:347-351, 1996

Newbold RR, McLachlan JA. Transplacental hormonal carcinogenesis: diethylstilbestrol as an example. Prog Clin Biol Res394:131-147, 1996

Noyes N, Liu HC, Sultan K, Rosenwaks Z. Endometrial pattern in diethylstilboestrol-exposed women undergoing in-vitro fertilization may be the most significant predictor of pregnancy outcome. Hum Reprod 11:2719-2723, 1996

PA health department offers information on DES. Pa Med 99:24, 1996

Palmlund I. Exposure to a xenoestrogen before birth: The diethylstilbestrol experience. J Psychosom Obstet Gynaecol 17:71-84, 1996

Rinehart CA, Xu LH, Van Le L, Kaufman DG. Diethylstilbestrol-induced immortalization of human endometrial cells: Alterations in p53 and estrogen receptor. Molec Carcinog 15:115-123, 1996

Salle B, Sergeant P, Awada A, Bied-Damon V, Gaucherand P, Boisson C, et al. Transvaginal ultrasound studies of vascular and morphological changes in uteri exposed to diethylstilbestrol in utero. Hum Reprod 11:2531-2536, 1996

Townsend DE. Primary non-clear cell adenocarcinoma of the vagina in older DES-exposed women. Gynecol Oncol 61:454, 1996

Wingard DL, Cohn BA, Helmrich SP, Edelstein SL. DES awareness and exposure: The 1994 California Behavioral Risk Factor Survey. Am J Prev Med 12:437-441, 1996

1997

Hanselaar A, van Loosbroek M, Schuurbiers O, Helmerhorst T, Bulten J, Bernheim J. Clear cell adenocarcinoma of the vagina and cervix. An update of the central Netherlands registry showing twin age incidence peaks. Cancer 79:2229-2236, 1997

Li S, Washburn KA, Moore R, Uno T, Teng C, Newbold RR, McLachlan JA, Negishi M. Developmental exposure to diethylstilbestrol elicits demethylation of estrogen-responsive lactoferrin gene in mouse uterus. Cancer Res 57:4356-4359, 1997

Pal L, Shifren JL, Isaacson KB, Chang Y, Marean M, Leykin L, et al. Outcome of IVF in DES-exposed daughters: Experience in the 90s. J Assist Reprod Genet 14:513-517, 1997

Sangvai M, Thie J, Hofmann GE. The effect of intrauterine diethylstilbestrol exposure on ovarian reserve screening. Am J Obstet Gynecol 177:568-572, 1997

Taylor HS, Vanden Heuvel GB, Igarashi P. A conserved Hox axis in the mouse and human female reproductive system: Late establishment and persistent adult expression of the Hoxa cluster genes. Biol Reprod 57:1338-1345, 1997

Tournaire M, Lepercq J, Epelboin S. The daughters of diethylstilbestrol. Lessons from an error. Eur J Obstet Gynecol Reprod Biol 75:25-27, 1997

Walker BE. Haven MI. Intensity of multigenerational carcinogenesis from diethylstilbestrol in mice. Carcinogenesis 18:791-793, 1997

1998

DES daughters and cancer. Health News 4:6, 1998

Erskine JM. The complete control and possible cure of a recurrent carcinoma of the breast by means of hormonal therapy over a 22-year period: A case report. Am J Clin Oncol 21:624-625, 1998

Garbin O, Ohl J, Bettahar-Lebugle K, Dellenbach P. Hysteroscopic metroplasty in diethylstilboestrol-exposed and hypoplastic uterus: A report on 24 cases. Hum Reprod 13:2751-2755, 1998

Gell JS, Oh J, Rainey WE, Carr BR. Effect of estradiol on DHEAS production in the human adrenocortical cell line, H295R. J Soc Gynecol Investig 5:144-148, 1998

Hatch EE, Palmer JR, Titus-Ernstoff L, Noller KL, Kaufman RH, Mittendorf R, Robboy SJ, Hyer M, Cowan CM, Adam E, Colton T, Hartge P, Hoover RN. Cancer risk in women exposed to diethylstilbestrol in utero. JAMA 280:630-634, 1998

Li Y, Rinehart CA. Regulation of keratinocyte growth factor expression in human endometrium: Implications for hormonal carcinogenesis. Molec Carcinog 23:217-225, 1998

Ma L, Benson GV, Lim H, Dey SK, Maas RL. Abdominal B (AbdB) Hoxa genes: regulation in adult uterus by estrogen and progesterone and repression in Muellerian duct by the synthetic estrogen diethylstilbestrol (DES). Dev Biol 197:141-154, 1998

Miller C, Degenhardt K, Sassoon DA. Fetal exposure to DES results in deregulation of Wnt7a during uterine morphogenesis.Nature Genet 20:228-230, 1998

Newbold RR, Hanson RB, Jefferson WN, Bullock BC, Haseman J, McLachlan JA. Increased tumors but uncompromised fertility in the female descendants of mice exposed developmentally to diethylstilbestrol. Carcinogenesis 19:1655-1663, 1998

Sanderson M, Williams MA, Daling JR, Holt VL, Malone KE, Self SG. Maternal factors and breast cancer risk among young women. Paediatr Perinat Epidemiol 12:397-407, 1998

Santti R, Makela S, Strauss L, Korkman J, Kostian ML. Phytoestrogens: Potential endocrine disruptors in males. Toxicol Ind Health 14:223-237,1998

Schuler M, Hasegawa L, Parks R, Metzler M, Eastmond DA. Dose-response studies of the induction of hyperdiploidy and polyploidy by diethylstilbestrol and 17beta-estradiol in cultured human lymphocytes using multicolor fluorescence in situ hybridization. Environ Molec Mutagen 31:263-273, 1998

Shiau AK, Barstad D, Loria PM, Cheng L, Kushner PJ, Agard DA, Greene GL. The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen. Cell 95:927-937, 1998

Vingerhoets AJ, Assies J, Goodkin K, Van Heck GL, Bekker MH. Prenatal diethylstilbestrol exposure and self-reported immune-related diseases. Eur J Obstet Gynecol Reprod Biol 77:205-209, 1998

1999

Helmrich SP, Anderson DA, Palmer JR, Shena SA, Herbst AL. The DES Clear Cell Cancer Cohort described. Manuscript in preparation

Kerjean A, Poirot C, Epelboin S, Jouannet P. Effect of in-utero diethylstilboestrol exposure on human oocyte quality and fertilization in a programme of in-vitro fertilization. Hum Reprod 14:1578-1581, 1999

Lempert P. Myopia in diethylstilboestrol exposed amblyopic subjects. Br J Ophthalmol 83:126, 1999


*NIH Workshop: Long-term effects of exposure to diethylstilbestrol (DES), April 22-24, 1992 (This publication is a comprehensive summary of the history and status of DES exposure and research up to 1992 and includes several topic-driven bibliographic listings reflective of these historical research perspectives.)


Home Inroduction/Background Opening Remarks State of the Research Advocates' Remarks Recommendations and Findings Closing Remarks Appendices