US 7,378,500 B2
	Use of thrombin-derived peptides for the therapy of chronic dermal ulcers
Darrell H. Carney, Dickinson, Tex. (US)
Assigned to Orthologic Corp., Tempe, Ariz. (US)
Filed on Apr. 04, 2006, as Appl. No. 11/397,310.
Application 11/397310 is a continuation of application No. 10/766752, filed on Jan. 27, 2004, granted, now 7,049,294.
Application 10/766752 is a continuation of application No. PCT/US02/01151, filed on Jan. 16, 2002.
Claims priority of provisional application 60/308198, filed on Jul. 27, 2001.
Prior Publication US 2006/0241049 A1, Oct. 26, 2006
This patent is subject to a terminal disclaimer.
Int. Cl. C07K 14/00 (2006.01)

U.S. Cl. 530—350

6 Claims

1. A method of treating a chronic ulcer below the kneecap in a diabetic subject in need of treatment, said method comprising administering to the ulcer an effective amount of the polypeptide Ala-Gly-Tyr-Lys-Pro-Asp-Glu-Gly-Lys-Arg-Gly-Asp-Ala-Cys-Glu-Gly-Asp-Ser-Gly-Gly-Pro-Phe-Val-NH2 (SEQ ID NO:6), wherein the polypeptide is administered to the ulcer alone or in combination with an antimicrobial, a disinfectant, an antibiotic, an analgesic or an anti-inflammatory agent.