DAVID Gene Report
3028623
interleukin 6 (interferon, beta 2) Related Genes Homo sapiens
SP_COMMENT
PTM:N- and O-glycosylated.,
disease:At least 1 polymorphism in the IL6 gene renders HIV-infected men susceptible to Kaposi sarcoma [MIM:148000]. Kaposi sarcoma is a sarcoma of spindle cells mixed with angiomatous tissue. A relatively rare malignant skin tumor that results in multifocal purplish coloured papules or plaques that eventually form nodules. Most commonly seen in patients who suffer from AIDS.,
disease:Genetic variations in IL6 are associated with susceptibility to systemic juvenile rheumatoid arthritis [MIM:604302]. Systemic juvenile rheumatoid arthritis is juvenile chronic arthritis associated with severe, debilitating, extraarticular features, and occasionally fatal complications. Despite medical treatment, many children still experience early joint destruction, necessitating surgical replacement.,
function:IL-6 is a cytokine with a wide variety of biological functions: it plays an essential role in the final differentiation of B-cells into Ig-secreting cells, it induces myeloma and plasmacytoma growth, it induces nerve cells differentiation, in hepatocytes it induces acute phase reactants.,
polymorphism:Genetic variations in IL6 may be correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disrutption of bone microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture.,
similarity:Belongs to the IL-6 superfamily.,
subcellular location:Secreted.,
OMIM_DISEASE
Kaposi sarcoma, susceptibility to ,
Osteopenia/osteoporosis ,
REFSEQ_PROTEIN
NP_000591 ,
REFSEQ_MRNA
NM_000600 ,
GENPEPT_ACCESSION
AAA52728 ,
AAA52729 ,
AAA59154 ,
AAC41704 ,
AAD13886 ,
AAH15511 ,
AAH27978 ,
AAK48987 ,
AAS07539 ,
AAV38553 ,
AAV38554 ,
ABM82389 ,
ABM85565 ,
CAA00839 ,
CAA27990 ,
CAA27991 ,
CAA28026 ,
CAA28268 ,
CAA68278 ,
CAG29292 ,
CAL23031 ,
EAL24265 ,
EAW93756 ,
EAW93757 ,
EAW93758 ,
Genomic_DNA ,
mRNA ,
GENE_SYMBOL
LOC541472 ,
GENE_NAME
B-cell stimulatory factor 2,
BSF-2,
CDF,
CTL differentiation factor,
Hybridoma growth factor,
IL-6,
IL6 protein,
Interferon beta-2,
Interferon, beta 2,
Interleukin 6,
Interleukin 6 (Interferon, beta 2), isoform CRA_a,
Interleukin-6 precursor,
Interleukin-6 precursor (IL-6) (B-cell stimulatory factor 2) (BSF-2) (Interferon beta-2) (Hybridoma growth factor) (CTL differentiation factor) (CDF),
LOC541472 protein,
Putative uncharacterized protein IL6,
Putative uncharacterized protein IL6 (Interleukin 6 (Interferon, beta 2), isoform CRA_a) (Interleukin 6) (Interferon, beta 2) (IL6 protein),
hypothetical LOC541472,
interleukin 6 (interferon, beta 2),
GENERIF_SUMMARY
IL-6 stimulates proliferation of rat pituitary tumor cells in culture, inhibits secretion of prolactin and growth hormone and induces tyrosine phosphorylation of STAT3 in the cells. ,
Individuals genetically predisposed to produce high levels of IL-6 during aging are disadvantaged for longevity. ,
Data demonstrate that exercise activates transcription of the IL-6 gene in working skeletal muscle, a response that is dramatically enhanced when glycogen levels are low. ,
Interleukin-6 stimulates thyrotropin receptor expression in human orbital preadipocyte fibroblasts from patients with Graves' ophthalmopathy ,
Interleukin (IL)-6 protein concentrations are increased approximately 18-fold in clinically localized prostate cancers when compared to normal prostate tissue. ,
Autocrine production of interleukin 6 causes multidrug resistance in breast cancer cells. ,
Levels of IL-6 were significantly higher in patients with dyslipidemia as compared with the healthy controls ,
Interleukin-6, tumor necrosis factor alpha and interferon gamma serum levels in patients with anorexia nervosa. ,
Pancreatic periacinar myofibroblasts secrete a large amount of IL-6 in response to proinflammatory cytokines IL-17, IL-1 beta, and TNF-alpha. ,
detection in pericardial fluid in coronary pathologies ,
Function and molecular modeling of the interaction between human interleukin 6 and its HNK-1 oligosaccharide ligands ,
Expression of Interleukin-6 (IL-6) and IL-6 receptor mRNA in human bone samples from pre- and postmenopausal women. ,
biosynthesis induced by tnf-alpha or interleukin 1 beta in human fibroblast-like synoviocytes increases with cell passage ,
Heat shock factor 1 represses transcription of the IL-1beta gene through physical interaction with the nuclear factor of interleukin 6 ,
Il-6 and oncostatin M act synergistically to promote growth in a new human myeloma cell line. ,
Certoparin but not UFH led to a dose-dependent increase in IL-6 from non-stimulated PBMC. ,
NADH significantly stimulated the dose-dependent release of IL-6 from peripheral blood leukocytes.The biological relevance of these data is discussed in the context of the recent use of NADH for the treatment of several neurodegenerative disorders. ,
Increased plasma levels of interleukin-6 and interleukin-8 are observed in beta-thalassaemia major patients and may be relevant in the pathophysiology of beta-thalassaemia ,
In dengue shock syndrome pts, IL-6 was significantly associated with both activation markers of coagulation (F1+2; p < 0.03) and fibrinolysis (PAPc; p = 0.002). IL6 is involved in the onset and regulation of hemostasis ,
IL-6 a key cytokine in in vitro and in vivo response of Sertoli cells to external gamma irradiation ,
Cancer cachexia is mediated in part by the induction of IL-6-like cytokines from the spleen. ,
secretion induced by combined effects of protein kinase C and ERK activation with TFF-papetide and TNF-alpha ,
Shedding of the interleukin-6 (IL-6) receptor (gp80) determines the ability of IL-6 to induce gp130 phosphorylation in human osteoblasts. ,
The -597 G-->A and -174 G-->C polymorphisms in the promoter of the IL-6 gene are associated with hyperandrogenism. ,
polymorphism -174G/C does not contribute substantially to hyperlipidaemia and Type II diabetes mellitus in Japanese men ,
results suggest that IL-6 is a mediator of the effects of Crohn's serum on in vitro mineralization and may be a contributing factor to the osteopenia associated with Crohn's disease ,
TNF-alpha induced IL-6 gene expression in airway smooth muscle (ASM) cells via a nuclear factor (NF)-kappaB-dependent pathway ,
Fas engagement increases expression of interleukin-6 in human glioma cells. ,
process of cervical dilatation during parturition at term is associated with an increased expression of interleukin-1 beta, interleukin-6 and interleukin-8 mRNA in the lower uterine segment ,
Reproductive hormone-induced, STAT3-mediated interleukin 6 action in normal and malignant human ovarian surface epithelial cells. ,
Secretion levels of sIL-2R, IL-6, IL-8, IL-10, and TNF-alpha, but not IL-4 and IL-12, are elevated in activated T-cells in large granular lymphocytic leukemia associated with autoimmune disorders. ,
the effects of high glucose in concert with AGII on IL-6 production in human mesangial cells and the modulation by blocking AGII ,
determine the cellular contents and concentrations of interleukin 6 (IL-6), interleukin 8 (IL-8) and tumour necrosis factor alpha (TNF-alpha) in fluids of patients with spermatocele or epididymal cyst ,
expressed in multiple sclerosis brain lesions ,
findings suggest that the IL-6prom G allele which may affect plasma IL-6 concentration might be a risk factor for sporadic AD in Japanese ,
high concentrations of IL-6 in the mid-secretory phase, the putative implantation window, and a further increase in the late secretory phase, the premenstrual period, support a role of IL-6 in the regulation of endometrial functions ,
IL-6 has a role in contributing directly to paclitaxel and doxorubicin resistance in U-2OS through a non-MDR-1 pathway. ,
secretion from acute myelogenous leukemia blasts was up-regulated by leptin ,
IL-6 induced activation of full-length LCAT promoter activity. A minimal IL-6 response element mapped within the distal promoter and was sufficient to mediate the IL-6 response ,
These results suggest that polymorphism of the IL-6 gene may be a useful marker for reduced bone mineral density. ,
VEGF and IL-6 were both independent prognostic factors for overall survival of aggressive lymphoma ,
Interleukin-6 production is induced in smooth muscle cells by monocyte chemoattractant protein-1 via differential activation of nuclear factor-kappa B. ,
The role of interleukin-6 in the development of functionally defective dendritic cells in multiple myeloma.IL-6 inhibited the colony growth of CD34(+)DC progenitors and switched the commitment of CD34(+) cells from DCs to monocytic cells. ,
IL-6 is produced by human adipocytes and is a potential marker of adipocyte differentiation; it is a hormonally regulated cytokine, suppressed by glucocorticoids, and stimulated by catecholamines and insulin in physiological concentrations ,
identification of the positive role of IL-6 in the secretolytin release from monocytes in vitro ,
Glutamine decreases rhis and interleukin-8 but not nitric oxide and prostaglandins e(2) production by human gut in-vitro. ,
Endotoxin-stimulated production is increased in short-term cultures of whole blood from healthy term neonates. ,
Impaired glucose tolerance is associated with increased serum concentrations. ,
The loss of response to IL-6 is an important step in the process of adrenal tumorigenesis. IL-6 stimulates cortisol secretion from adrenal cells. IL-6 mRNA is upregulated in adrenal adenomas from Cushing syndrome patients. ,
Simvastatin reduces expression of the proinflammatory cytokine interleukin-6 in circulating monocytes from hypercholesterolemic patients. ,
role of p38 map kinase, NF-kappaB, and protein kinase c in IL-6 mRNA expression by human peripheral blood leukocytes, monocytes, and neutrophils in response to Anaplasma phagocytophila ,
Acanthamoeba castellanii by release of ADP and other metabolites lead to human monocytic cell death through apoptosis and stimulate the secretion of IL-6 ,
IL-6 gene region may contribute to susceptibility to HTLV-I associated myelopathy ,
Inheritance of the G/G genotype of both IL-1B and IL-6 was a particularly strong predictor for the development of recurrent aphthous stomatitis. ,
IL-7 may function to regulate the milieu of the microenvironment by modulating IL-6 secretion by the IL-7R-expressing stromal elements ,
regulation of synthesis by isoflavones during osteoblast cell differentiation via an estrogen-receptor-dependent pathway ,
These results suggest that hepatocyte growth factor and interleukin-6 upregulate each other's receptors, and thus cooperatively enhance tissue invasion. ,
Normal and SV40 transfected human peritoneal mesothelial cells produce IL-6 and IL-8 ,
activation of the hIL-6 gene by HHV-8/KSHV. role of hIL-6 in the development of Kaposi sarcoma. ,
activation of the ERK pathway is involved in the induction of IL-6 mRNA stabilization by IL-17 plus TNF-alpha. ,
the IL-6 G(-174)C polymorphism is not associated with the risk of CAD or MI and does not contribute to cardiovascular risk stratification. ,
The endogenous levels of TPO, IL-6 and IL-8 are elevated in the thrombocytopenic patients with AML and MDS. ,
an independent predictor of mortality in patients starting dialysis treatment ,
Hepatocyte growth factor as cardiovascular hormone ,
IL-6 levels were not correlated with seminal parameters. IL-6 and TNF-alpha may be involved in male fertility. ,
IL-6 in combination with its recombinant receptor enhances the expression of receptor activator of NF-kappa B ligand (RANKL) and osteoprotegerin in neonatal mouse calvarial bone cultures, while decreasing RANK expression. ,
Interleukin-10 activates the transcription factor C/EBP and the interleukin-6 gene promoter in human intestinal epithelial cells. ,
Review. We review the evidence for the involvement of IL-6 in the pathophysiology of autoimmune diseases and chronic inflammatory proliferative diseases (CIPD) and discuss the possible molecular mechanisms of its involvement ,
role in human herpesvirus-8 replication ,
antagonism by a homodimeric form of recombinant interleukin-6 ,
human IL6 expression mediates elements of the systemic inflammatory response in pancreatic tumor cell lines ,
IL-6 expression is modulated by hormone replacement therapy in postmenopausal women ,
Interleukin-6 down-regulates TFF expression in human stomach neoplasm cells cultivated in vitro. ,
results strongly suggest that the IL-6-induced tyrosine-phosphorylation and activation of STAT3 were suppressed by overexpression of the nuclear isoform of TC-PTP in 293T cells ,
Rta expression during lytic reactivation of HHV-8 would lead to expression of some cellular genes, including IL-6, whereas activation of NF-kappa B could inhibit some responses to transcription activator, Rta ,
results indicate that mouse IL-19 may play some important roles in inflammatory responses because it up-regulates IL-6 and TNF-alpha and induces apoptosis [IL-19] ,
Carriers of the -174C-allele (genotype GC/CC) had an inferior three-year graft survival (71/104 = 68.3%; P = 0.0059) with a 3.7-fold increased relative risk of graft loss compared to carriers of the -174GG-genotype (48/54 = 88.9%). ,
Human bone marrow-derived mesenchymal cells do not differentiate into the osteogenic lineage until Gp130 is activated by soluble IL-6 receptors and IL-6. ,
IL-6 production induced by hydrostatic pressure stresses was dependent on the PKC signaling pathway. ,
results suggest that tumor necrosis factor-alpha and interleukin-6 are involved in endotoxin-induced anorexia in humans ,
Release of IL-6 from oncostatin M-stimulated peritoneal mesothelial cells is dose- and time-dependent and contributes to the control of leukocyte recruitment by the soluble IL-6 receptor. ,
IFN-gamma shifts monocyte differentiation to macrophages rather than DCs through autocrine M-CSF and IL-6 production. ,
Inhibition of p38 MAPK inhibits IL-6 and VEGF secretion in bone marrow stromal cells triggered by adherence of multiple myeloma cells. ,
cystatins SA1 and SA2 adhere to human fibroblasts and that the event results in tyrosine phosphorylation and upregulation of the release of IL-6 mediated enhancement of NF-kappa B activity. ,
results show for the first time that interleukin-6 (IL), in the presence of its soluble receptor (sIL-6R), induces activation of JAK1, JAK2, and STAT1/STAT3 proteins in bovine articular chondrocytes ,
growth mechanism of human myeloma cells by interleukin-6 ,
a multifunctional cytokine which causes contrasting effects in prostate cancer cells; may have an important role in progression of prostate cancer towards resistance to endocrine therapy [review] ,
in basal cell carcinoma cells, the upregulation of the anti-apoptotic Mcl-1 protein by interleukin-6 is mainly through the Janus tyrosine kinase/phosphotidyl inositol 3-kinase/Akt, but not the STAT3 pathway. ,
soluble proteins of tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and IL-6 receptor subunit gp80 (sIL-6R gp80), as markers of multiple sclerosis ,
The presence of high-expression polymorphisms at position -174 of the IL-6 gene significantly increases the risk for bronchiolitis obliterans syndrome development after lung transplantation. ,
IL6 regulates growth-related gene espression in murine myeloma cells ,
levels in children with acute and chronic idiopathic thrombocytopenic purpura and their relationship with mega-dose methylprednisolone therapy ,
IL-18 is a promising candidate for the enhanced secretion of IL-6 by human neutrophils. ,
The IL-6 -174G>C polymorphism combined with IL-6 plasma levels may chronically predispose an individual to develop atherosclerosis. ,
role in inducing N-ras and K-ras in myeloma cells ,
An examination of quantitative gene expression of this protein in the renal artery wall of chronically rejected human renal allografts. ,
IL-6 ,
IL-6 may be linked to the regulation of glucose homeostasis during exercise. The observation of a relationship between IL-6 release and muscle glycogen store both at rest and after exercise suggests that IL-6 may act as a carbohydrate sensor. ,
The interleukin-6 promoter polymorphism -174 G/C does not contribute significantly to overall disease susceptibility but does predispose the carrier to distinct endometriosis with chocolate cysts ,
Paracrine interactions of basic fibroblast growth factor and interleukin-6 in multiple myeloma ,
describe two functional polymorphisms in the IL-6 gene regulatory region associated with IL-6 activity in postmenopausal women both systemically (C-reactive protein) and locally in bone ,
The promoter polymorphism of this gene affects energy expenditure and insulin sensitivity. ,
only in a subset of both benign and malignant thyroid nodules the interleukin-6/interleukin-6 receptor signal could be induced by the CD30 ligand/CD30 ,
data demonstrated that Hsp90 may function as a stabilizer of an IL-6-mediated signal-transducing molecule, STAT3, by directly interacting with STAT3 ,
IL-6 mediates insulin resistance with SOCS-3 in the liver ,
in men, the IL6 -174G/C polymorphism is associated with some indices of body composition and parameters of glucose and insulin homeostasis ,
Although known to alter IL-6 expression, the IL-6 polymorphism investigated was not associated with idiopathic recurrent miscarriage and alterations in IL-6 serum levels in a Middle-European Caucasian population. ,
Recombinant human IL-6 induces from peripheral blood mononuclear cells the formation of osteoclastic cells, which are positive for tartrate-resistant acid phosphatase, vitronectin receptor, and calcitonin receptor and capable of lacunar resorption. ,
IL-6 secreted during an aseptic inflammatory state, such as sustaining head trauma with SIADH, is quantitatively correlated to AVP, indicating that this cytokine is directly and/or indirectly involved in the pathogenesis of SIADH. ,
found that the G/C polymorphism in the IL6 promoter region is associated with development of type-2 diabetes mellitus in Native Americans and Caucasians; Pima Indians have a higher frequency of the GG genotype than Caucasians ,
Inhibition of IL-6+IL-6 soluble receptor-stimulated aromatase activity by the IL-6 antagonist, Sant 7, in breast tissue-derived fibroblasts ,
Bradykinin induces IL-6 production in human airway smooth muscle cells. ,
combined elevation of interleukin-1beta and interleukin-6, rather than the isolated elevation of interleukin-6 alone, independently increases the risk of type 2 diabetes ,
IL-6 and GM-CSF may be involved in the autoimmune mechanism of non-segmental vitiligo. ,
STAT3 activation induced by IL-6 in primary human macrophages is affected differentially compared to STAT3 activation by IL-10, by mechanisms that suppress the Jak1/STAT3 pathway, despite the ability of the two cytokines to signal via similar pathways. ,
We conclude that IL-6 may promote cervical tumorigenesis by activating VEGF-mediated angiogenesis via a STAT3 pathway. ,
Interleukin-6 levels were elevated 5-fold in preeclamptic plasma. Human umbilical vein endothelial cell interleukin-6 production was increased 25% by preeclamptic plasma. plasma. ,
Synergistic effect of -174 G/C polymorphism of the interleukin-6 gene promoter and a polymorphism of the intercellular adhesion molecule-1 gene in Italian patients with history of ischemic stroke. ,
The significant correlation of IL-6 and fructose levels indicates that the seminal vesicles take part in the production of seminal IL-6. ,
lack of role in expression of Mcl-1 in multiple myeloma ,
This study provides further evidence that IL-6, leptin, and adiponectin are associated with impaired fibrinolysis in overweight hypertensive humans. ,
data suggest a transcriptional mechanism leading to decreased adiponectin plasma levels in obese women and demonstrate that low levels of adiponectin are associated with higher levels of C-reactive protein and interleukin-6 ,
the thermotolerant effect of IL-6 is independent of the heat shock response ,
IL-6 release from human adipocytes is stimulated in the autocrine/paracrine system by IL-1beta ,
IL-6 precludes the negative effects induced by IL-3 on cord blood CD34+ cell expansion and telomerase activity. ,
interleukin-6 stimulates mast cell adhesion to extracellular matrix and thus allows for the accumulation of the cells at tissue sites by enhancing integrin expression ,
MTmRNA is high in lymphocytes from elderly people coupled with high IL-6, low zinc ion bioavailability, decreased NK cell activity and impaired capacity of PARP-1 in base excision DNA-repair. ,
reduction in the frequency of GG homozygotes in the octo/nonagenarian age group and a higher serum IL-6 level associated with CC homozygotes with reciprocal changes for the anti-inflammatory cytokine IL-10. ,
higher IL6 promoter activity may confer risk to type 1 diabetes mellitus in very young females ,
IL-8 increased by 30% after weight loss. IL-8 and IL-6 correlated with measures of insulin resistance, and changes in IL-6 but not IL-8 were correlated with improvement in insulin sensitivity after weight loss. ,
parallel expression with cyclooxygenase-2, interleukin-1beta, and NF-kappaB in colorectal cancer ,
Constitutive activation of nuclear factor kappaB p50/p65 and Fra-1 and JunD is essential for deregulated interleukin 6 expression in prostate cancer. ,
combination of low insulin-like growth factor-I and high interleukin-6 levels confers a high risk for progressive disability and death in older women ,
in healthy adults, age-related alterations in nocturnal wake time and daytime sleepiness are associated with elevations of both plasma interleukin-6 and cortisol concentrations, but REM sleep decline with age is associated with cortisol increases ,
A disease-modifying effect of IL-6 C allele could not be demonstrated in multiple sclerosis patients of German Caucasian descent. ,
Giant cell arteritis patients with ischemic complications have lower tissue expression and circulating levels of IL-6 than patients with no ischemic events; IL-6 effects on vascular wall components may be protective ,
intestinal epithelial and smooth muscle cells demonstrate the ability to release significant amounts of IL-6.Human intestinal parenchymal cells, influenced by paracrine mediators might contribute to the systemic inflammatory response by producing IL-6. ,
might also be valuable biochemical marker in the evaluation of oocyte maturation ,
there appeared to be no significant associations between IL6 promoter variants and disease outcome in chronic hepatitis B ,
The level of IL-6 secretion in the gastric cancer cell lines correlated with the level of soluble IL-6R secretion, and was significantly higher (< approximately 100 pg/ml) than the level of IL-6 secretion in the colorectal cancer cell lines. ,
There is a positive association of IL6 promoter variant with bone mineral density in pre-menopausal women. ,
we found no significant association between the -174 G/C interleukin-6 polymorphism and the occurrence or the clinical features of migraine ,
High levels of interleukin 6 is associated with hormone-refractory metastatic breast cancer ,
IL-6 derived from blood during breakdown of blood-retinal barrier and produced by retinal pigment epithelial(RPE) cells and hematogenous soluble interleukin-6 receptor cause RPE proliferation. ,
Elevated serum interleukin-6 correlates with the increased serum butyrate level in patients with nasopharyngeal carcinoma ,
exercise results in an increase in IL-6 gene expression in adipose tissue in response to exercise, an effect that is significantly blunted by ingestion of carbohydrate ,
IL-6 is found to be significantly higher in the cerebrospinal fluid of the "delayed-responders" than the "poor-responders" subtype of schizophrenics and the controls. ,
Data show that angiogenin isolated from cow milk induces the production of cytokines interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha in human leukocytes. ,
Presence of a common G/C polymorphism at position was the best predictor of disease-free survival in ovarian cancer. It influences the biological phenotype of ovarian cancer because it is associated with early stage and improved DFS and overall survival. ,
Data suggest that interleukin-6 activation of gp130 promoted cell division in fibroblasts from patients with idiopathic pulmonary fibrosis (IPF), while IL-11 was mitogenic in both normal and IPF cells. ,
Promoter polymorphism in this gene predicts the conversion from impaired glucose tolerance to type 2 diabetes. ,
a structural model, derived from 3.65 A resolution crystallographic data of the complex between IL-6, the extracellular binding domains of IL-6R, and the extracellular activation and binding domains of gp130 is presented ,
involvement of IL-6 in the pathogenesis of liver diseases and suggest a protective role of IL-6/gp130-dependent pathways in nonparenchymal liver cells during fibrosis progression in chronic liver diseases ,
systemic antibody responses against Salmonella typhimurium LPS are largely effected by IL-6 and, moreover, the amount and the cellular location of recombinantly expressed IL-6 appears to be crucial for enhancement of immune responses. ,
Hyperketonemia increases IL-6 levels in the blood of type 1 diabetic patients. ,
Common polymorphisms in this protein are associated with increased risk of colorectal cancer. ,
mechanism through which chronic stressors may accelerate risk of a host of age-related diseases by prematurely aging the immune response ,
IL-6 and osteocalcin genes are susceptibility loci for reduced bone mineral density in postmenopausal women ,
Serum concentrations of IL-6, sgp130, and sIL-6R were measured in stroke patients and controls. The data demonstrate genetic variation in the expression of IL-6 in stroke ,
association between the IL-6 promoter polymorphism -174G/C and high blood pressure and LVH in hemodialysis patients, especially those with diabetes ,
Higher cytosol IL6 levels were found in the walls of ruptured aneurysms than in the asymptomatic aneurysms. ,
data demonstrate that the hepatosplanchnic viscera remove interleukin-6 from the circulation; this removal may constitute a mechanism limiting the negative chronic metabolic action of chronically elevated circulating IL-6 ,
study suggests that muscle-derived interleukin-6 has a central role in exercise-induced leukocyte trafficking ,
trend for augmented exercise-induced IL6 release in type 2 diabetics; results also suggest that neither type 2 diabetic nor healthy skeletal muscle releases IL6 at rest,indicating that other organs contribute to elevated basal IL6 in type 2 diabetics ,
serum and cyst fluid levels of interleukin (IL)-6, IL-8 and tumour necrosis factor-alpha (TNF-alpha) were evaluated in women with endometriomas and compared with those in women with benign or malignant ovarian tumours. ,
adipose tissue mRNA of tumor necrosis factor-alpha, interleukin-6, and interleukin-8 was increased in HIV-associated lipodystrophy syndrome subjects ,
IL-6 may function as a direct hepatic mitogen in vivo ,
IL-6 has a role in growth inhibition of human myeloma cells induced by HMG-CoA reductase inhibitor ,
IL-6 response elements have roles in transactivating Stat3 on fibrinogen promoters with additional transcription factors during acute phase response ,
mechanism for the secretion of IL-6 from endothelial cells in response to uni-axial continuous stretch ,
upregulation of TLR-4 via IL-6 can increase the responsiveness of mononuclear phagocytes ,
A high serum level of IL-6 is significantly associated with a high serum level of CEA in preoperative colorectal cancer patients. ,
Two polymorphic regions of the interleukin-6 (IL-6) gene were investigated in patients with Alzheimer's disease and non-demented controls. The -174 C allele in the promoter region of IL-6 gene was over-represented in AD patients. ,
Spinal administration of recombinant human IL-6 to rats following spinal nerve ligation demonstrates inhibitory effects on C-fiber activity and suggests that IL-6 is a potential modulator of neuropathic pain. ,
up-regulated to a greater extent in patients with influenza-associated encephalopathy than in those without neurologic complications ,
both 5'-AMP-activated protein kinase and interleukin-6 are independent sensors of a low muscle glycogen concentration during exercise ,
A continuous rise of IL-6 and a transient elevation of IL-10 during liver cancer surgery. ,
IL-6 can play an important role in insulin resistance ,
Skeletal muscle fibers are the dominant cell source of exercise-induced release of IL-6. ,
Activation of the NF-kappa B pathway by IL-6 is required for the induction of ICAM-1 expression in model intestinal epithelial cells. ,
IL-6 expression in UVB-irradiated human keratinocytes via cyclic AMP/protein kinase A pathway and a possible reduction of deleterious inflammatory effects of cytokine following by using pharmacological agents. ,
Regulation of most IL-6 target genes in a multiple myeloma cell line required the activation of Stat3, underscoring its central role for IL-6 signal transduction. ,
GNAS1 mutated stromal cells produce IL-6 at a basal magnitude and rate that are significantly higher than in the cognate wild-type cells ,
potential direct involvement of CRP and IL-6 in atherogenesis. ,
results indicate that leptin does not play a role in the pathogenesis of anorexia in children with failure to thrive but interleukin 6 may be an important factor ,
The (-174)GG-genotype of the IL-6 gene is associated with severe stroke in young patients with acute cerebrovascular events. ,
Skeletal muscle IL-6 production is regulated by an autocrine mechanism at the transcriptional level. ,
The IL-6 -174 GG genotype is associated with the development of septicemia in preterm infants. Variation in the IL-6 gene seems to influence the defense against bacterial pathogens in the very preterm infant. ,
DHT down-regulates NF-kappaB mediated IL-6 expression by human TCC lines in response to BCG. This effect depends on a functional androgen receptor signaling pathway and it can be blocked by the inhibition of androgen/androgen receptor binding. ,
the human pituitary cell line HP75 synthesizes IL-6 mRNA and expresses and secretes IL-6 ,
IL-6 secreted by Mycobacterium tuberculosis-infected macrophages inhibits the responses of uninfected macrophages to interferon-gamma. ,
During Rhinovirus upper respiratory tract infection, significant increases in mean levels of nasal interleukin 6 (IL-6) (P = .01) were observed in symptomatic but not asymptomatic subjects ,
Intratumoral IL-6, which is differently regulated by various factors, might contribute to excessive grwoth hormone production in the majority of somatotroph adenomas. ,
Cyclooxygenase 2 gene polymorphism is associated with squamous cell carcinoma. ,
MIF, TNF-alpha and IL-6 may participate in pathological process of chronic hepatitis B and cirrhosis. IL-6 may play important role in ascites formation. Serum MIF, TNF-alpha and IL-6 appear to reflect severity of tissue injury in hepatitis B. ,
Some levels, such as interleukin-6 and interleukin-8, may fluctuate during normal pregnancy. These spontaneous variations during pregnancy must be taken into account when mucosal immunologic responses to lower genital tract infection are being studied. ,
Microvessel endothelium of fetal placental vasculature produces both interleukin-6 and interleukin-8 in umbilical placental vascular disease. May play key role in interaction of endothelial cells of placenta villi with neighboring cells. ,
Increased serum levels of interleukin-6 in malnourished patients with colorectal cancer ,
Results suggests that IL-6 may be a reliable marker of disease outcome in studies based on novel approaches aiming at modifying age- and cancer-related biologic mechanisms. ,
IL-6 induced vascular endothelial growth factor 165 expression is enhanced by glucose via activation of gp130-mediated p44/42 MAPK-CCAAT/enhancer binding protein signaling ,
IL6 G-174C promoter polymorphism was associated with fat-free mass in men but not in women. ,
Endogenous production of IL-6 appears to protect fetal liver-derived mast cells (MC)and those of the lung MC(T) phenotype from human recombinant IL-4-mediated apoptosis, because neutralization of IL-6 renders these mast cells sensitive. ,
IGF-1, IGFBP-2 levels were related to IL levels, disease activity and anatomical distribution, consistent with active inflammation modifying the IGF-IGFBP system, possibly relevant to disturbance of growth. ,
Garlic supplementation increases resting tissue blood flow and this may be mediated by increases in serum IL-6. ,
IL-6 plays a critical role in the synergistic induction of human SAA gene when stimulated with proinflammatory cytokines ,
Although IL-6 levels were elevated in diabetic groups with and without diabetic nephropathy in comparison with the control, no significant difference was found between patient groups ,
Among Japanese women, those carrying the -634G allele of the IL-6 gene might have a decreased risk of recurrent pregnancy loss. ,
Unglycosylated humanhIL-6 is as potent as glycosylated hIL-6 in stimulating B cell proliferation. ,
Pim1 and Etk are required for IL6-induced activation of androgen receptor-mediated transcription in prostate cancer. ,
IL-6 directly modulated monocyte adhesion to endothelial cells. ,
These data suggest that moderate wine intake may acutely increase plasma levels of IL-6 in men with coronary artery disease. ,
IL-10 and IL-6 induce decorin mRNA transcription, but additional signals from the extracellular matrix are necessary for its translation. ,
In the blister fluid a significant difference (median +/- interquartile range, Wilcoxon signed-ranks test P < 0.05) was found between the involved and uninvolved extremity in IL-6 [53.5 (17.3-225) versus 6.2 (2-20.3) pg/ml] ,
-572 G/C polymorphism may be one of the protective factors associated with lower susceptibility to chronic periodontitis ,
IL-6 expression may be modulated by the composition of circulating free fatty acids ,
This is the first demonstration that IL-6, secreted by macrophages, can induce a STAT3-mediated IL-10 production by colon tumor cells. ,
In prostatectomy patients, preoperative plasma levels of TGF-beta(1) and IL-6 are associated with metastases to regional lymph nodes and disease progression. ,
Elevated il 6 levels in Barrett esophagus may contribute to the development of apoptosis resistance, thereby placing this epithelium at higher risk of developing malignancy. ,
data suggest that interleukin-6 may be a paracrine regulator of adipose tissue ,
results support the findings of a pathologic role for IL-6 in the neuroinflammatory response as related with the pathogenesis of neuronal degeneration ,
CC (low secreting) genotype was associated with a decreased risk of young adult Hodgkin lymphoma relative to the GG (high secreting) genotype ,
Obese patients with body mass index greater than or equal to 28 kg/m(2) carrying CC genotype showed more than 5-fold increased risk of developing type 2 diabetes mellitus compared with remaining genotypes and might profit most from weight reduction. ,
mRNA abundance of IL-6 and IL-8 appears to be influenced by glycogen availability in the contracting muscle. ,
circulating IL-6 is markedly elevated at rest and during prolonged moderate-intensity exercise when lipolysis is suppressed. ,
In end-stage renal disease on long-term hemodialysis, single nucleotide polymorphisms in promoter of IL-6, TNF-alpha, and IL-10 show strong association with indices of comorbidity and function, and biological and nutritional markers. ,
In a Con A-induced model of murine liver injury, recombinant human IL-6 suppresses the cytotoxicity of natural killer (NK)T cells and prevents hepatitis via targeting CD4+ T cells in a STAT3-dependent way. ,
IL-6 trans signaling differentially controls neutrophil-activating CXC chemokine expression. ,
IL-6 is released from ruptured vulnerable atherosclerotic plaque, and regional activation of macrophages is involved in occlusive process of coronary artery in acute myocardial infarction. ,
may participate in the pathogenesis of temporomandibular disorders and induce osseous changes in the condyle ,
concetration in children with acute lymphoblbastic leukemia after chemotherapy ,
evidence that the multifunctional cytokine, IL-6, may induce VEGF expression which increases angiogenesis in gastric carcinogenesis ,
interleukin-6 promoter is activated by a dominant negative mutant of c-Jun ,
IL-6 and sIL-6R may contribute to the pathogenesis of endometriosis-associated infertility ,
IVIG inhibits NF-kappaB activation induced by TNF-alpha in cultured endothelial cells of coronary arteries, thereby possibly modulating IL-6 production and E-selectin expression ,
The -174C allele is associated with higher BMI in type 2 diabetes, but not amongst healthy subjects. ,
In conclusion, fasting glucose and the extent to which glucose tolerance changes with exercise training may be influenced by the IL-6 -174 gene polymorphism. ,
In conclusion, epinephrine acutely increases IL-6 mRNA levels in subcutaneous adipose tissue as well as circulating IL-6 levels in healthy men. ,
These women were more likely to present with a body mass index >27 kg/m(2), elevated total T serum levels, and a pathological oral glucose tolerance test result. ,
Data do not support a pathogenic role in Alzheimer's disease for the C-174G polymorphism in the promoter of IL-6, which influences expression in vitro. ,
The effects of low concentrations of extracellular ATP on cytosolic Ca(2+), membrane potential, and transcription of IL-6 were studied in macrophages. ,
We believe that H. pylori-related cytokine activation becomes concentrated on gastric mucosa and this pathogen-induced local inflammatory cascade does not cause changes in circulatory levels of these cytokines. ,
IL-6 and IL-8 levels in all amniotic fluids and in all supernatants ,
IL-6 may influence glucose homeostasis during exercise. Potential new insights into factors that mediate glucose production and disposal and implicates IL-6 in the so-called "work factor." ,
No difference in serum level of normal and hemodialysis or peritoneal dialysis patients. ,
Blocking effect of IL-6 in humans may improve lupus by interacting with the autoinflammatory process both systemically and locally. (REVIEW) ,
Expreeeion of interleukin-6 in human osteoblast-like cells is suppressed by arginine-vasopressin. ,
high concentrations of leptin (100 nM) and/or PRL significantly (p<0.05) reduce the inhibitory effect of IL-6 (10 and 100 ng/ml) and TNF-alpha (10 and 100 ng/ml) on beta-casein gene expression in HC11 cells transfected with pbetacCAT ,
PIV-4 infection enhances epithelial IL-8 and IL-6 production by transcriptional and posttranscriptional mechanisms ,
Polymorphism in the IL-6 gene was associated with the severity of appendicitis and its outcome after appendectomy. ,
data reveal an important role for MgcRacGAP in STAT3 activation, and demonstrate that MgcRacGAP regulates IL-6-induced cellular differentiation in which STAT3 plays a pivotal role ,
study concluded that individuals homozygous for G allele on the interleukin-6 gene have higher values in some parameters associated with obesity ,
Ryanodine receptor 1 enhances the production of the inflammatory cytokine IL-6, which may in turn affect signaling pathways responsible for the trophic status of muscle fibers. ,
ICAM-1, VCAM-1, E-selectin and interleukin-6 expression are enhanced by glucose and regulated by poly(ADP-ribose) polymerase in human umbilical endothelial cells ,
The magnitude of exercise-induced IL-6 mRNA expression in contracting human skeletal muscle was markedly reduced by 10 weeks of training. ,
interleukin-1beta regulates interleukin-6-induced suppressor of cytokine signaling 3 expression ,
Our results indicate that TGF-beta(1) gene Arg(25)-->Pro, TNF alpha gene G-308A and IL-6 gene G-174C polymorphisms are not risk factors or markers of progression in focal segmental glomerulosclerosis ,
IL6 has a unique role in the progression of PCa. ,
Ater interaction with tracheal epithelial cells, Bordetella pertussis induces the secretion of interleukin-6. This is dependent on expression of adenylate cylcase/hemolysin by the bacteria. ,
A polymorphism in the inflammatory cytokine IL6, but not polymorphisms in angiogenesis-related genes, was associated with intracranial hemorrhage presentation of brain arteriovenous malformation. ,
Both IL-6 and LIF can be very efficiently induced by IL-1beta in articular chondrocytes in vitro, more so in osteosarthritis than in normal cells. ,
Reduced carbohydrate intake that results in low intramuscular glycogen leads to phosphorylation of p38 MAPK at the nucleus. This event is associated with IL-6 gene transcription during contraction. ,
The concentration of IL-6 was enhanced by IL-1beta in human trophoblast cells in a dose-dependent fashion ,
areca nut induction of prostaglandin E2 production, interleukin-6 production, cell cycle arrest, and cytotoxicity in primary oral keratinocytes and KB cancer cells is regulated by MEK/ERK activation ,
IL-6 plays an important role in the inflammatory reaction that occurs in the interface between the craniopharyngioma and the brain parenchyma ,
RANKL treatment induced a significant increase of IL-6 secretion by both bone marrow stromal & endothelial cells. ,
Acute IL-6 treatment increased fatty acid turnover ,
We conclude that upper extremity, low-intensity exercise results in a substantial increase in IL-6 in the interstitium of the stabilizing trapezius muscle, whereas no change is seen for plasma IL-6. ,
IL-6 and IL-10 polymorphisms act synergistically, with a fivefold decreased risk of AD being found in subjects who concomitantly carry the (-174) IL-6 C/C and the (-1,082) IL-10 A/A genotypes. ,
gene polymorphisms of cytokines playing a major regulatory role in the inflammatory response do not affect life expectancy in the Sardinian population. ,
frail older adults have both decreased LPS-induced proliferation and increased IL-6 production by peripheral blood mononuclear cells ,
variation of the gene that may increase IL-6 synthesis is associated with disabling brain injury but not cognitive development despite association with worse early critical care indices ,
Amniotic fluid interleukin-6 is increased in patients with cervical incompetence ,
expression upregulated in oral mucosa cells by Candida albicans and Streptococcus salivarius ,
Both -174G and -598G alleles were significantly associated with type 2 diabetes ,
secreted in cultured osteoblasts from uremia patients. ,
G-174C polymorphism of the IL-6 gene does not contribute to the development and severity of GO. ,
The double heterozygote AGCG of both IL-6 promoter polymorphisms was associated with cutaneous T-cell lymphoma ,
The additive concentration of cytokines in diabetes and CVD (cardiovascular disease)suggests a common inflammatory state in both diabetes and CVD. ,
the human nucleotide excision repair gene, hHR23B, is epigenetically silenced in interleukin-6-responsive multiple myeloma KAS-6/1 cells ,
Palmitate, but not linoleate, induced a significant increase in IL-6 mRNA expression in coronary artery endothelial cells. ,
IKK-beta/NF-kappa B transcription pathway is a key regulator of IL-6, IL-8, and TNF-alpha release from adipose tissue and skeletal muscle ,
Interleukin-6 is an important independent mediator of elevated C-reactive protein concentrations in patients with non-small-cell lung cancer. ,
extracellular ATP-induced IL-6 synthesis occurs through P2Y receptors and mobilization of Ca(2+) from internal stores in human osteoblastic cells ,
inhibition of protein tyrosine phosphatase by vanadate promotes hematopoietic differentiation activity of IL-6 through modulating multiple signalings, particularly actin filament polymerization ,
regulated by human cytomegalovirus (HCMV) at the posttranscriptional level. ,
The CC genotype of the IL-6 -174G>C polymorphism may be associated with a protective effect against retinal artery occlusion ,
IL-6 gene polymorphism may be a predisposing genetic factor that contributes to racial and ethnic differences in breast cancer prognosis. ,
GSK3 and PKB/Akt have roles in the integrin-mediated regulation of PTHrP, IL-6 and IL-8 in pancreatic cancer ,
heat shock-induced expression of MMP-1 and MMP-3 is mediated via an IL-6-dependent autocrine mechanism ,
The IL-6-mediated bFGF upregulation is through activation of JAK/STAT3 and PI3-Kinase/Akt pathways. ,
IL-6 release from monocytes under hyperglycemia appears to be mediated via upregulation of PKC, through p38 map kinase and NF-kappaB ,
induced and expressed in human alveolar epithelial cells by Legionella pneumophila after invasion. ,
Cellular and subcellular expression of TNF-alpha, IL-1alpha and IL-6 in hepatocytes inx chronic hepatitis C. ,
Single-nucleotide polymorphisms and composite genotypes or haplotypes of the IL6 promoter may be associated with several features of the metabolic syndrome in Caucasians. ,
IL-6 increases trafficking of TGF-beta1 receptors to non-lipid raft-associated pools resulting in augmented TGF-beta1 Smad signaling ,
IL-6 is associated with sleep quality and certain individual characteristics such as race, gender, and age modify that relationship. ,
Spliced form of IL-6 mRNA detected in renal cell carcinoma encodes for a truncated IL-6 with IL-6 antagonist properties. ,
These data demonstrate that TNF-alpha rather than IL-6 stimulates an increase in PAI-1 mRNA in the subcutaneous adipose tissue, suggesting that TNF-alpha may be involved in the pathogenesis of related metabolic disorders. ,
IL6 is upregulated in DDIT3- and FUS-DDIT3-expressing fibrosarcoma cell lines. ,
Interleukin 6 (IL-6) specifically enhances brain-derived neurotrophic factor secretion in monocytes and provides evidence that IL-6 represents a specific link between monocyte infiltration and neuronal changes in inflammatory diseases. ,
Oncostatin M stimulates proliferation of prostate cacner 22Rv1 cells, in part through activation of the phosphatidylinositol 3-kinase (PI 3-K) signaling pathway. ,
IL-6 increases hepatic PAI-1 expression mediated by the -232- to -210-bp region of the promoter containing a C/EBPdelta binding site. ,
predominant presence of high-producing IL-6 alleles together with low-producing IL-10 and IFN-gamma alleles in G6PD-deficient individuals with ancestry from malaria-endemic regions ,
It is shown for the first time that genetic alterations in the inflammatory mediator IL6 associate with intervertebral disc disease-related sciatica. ,
the HNF-3 site in the fibrinogen beta promoter is important for IL6-induced expression, and its activity is influenced by the adjacent -148C/T polymorphism ,
These data suggest that the increase in fatty acid utilization seen during exercise at moderate compared with low intensity is not mediated via alterations in plasma IL-6. ,
The significant associations between VEGF and the levels of IL6 and IL1 alpha suggest an important role for these cytokines in the development of these tumours. ,
hsCRP and IL-6 appear to be associated with small silent brain infarction, suggesting a role of inflammatory processes in cerebral small vessel disease ,
Elderly patients with postoperative confusion had increased plasma IL-6 and cortisol concentrations. The interaction between IL-6 and cortisol after surgery is associated with developing postoperative confusion in the elderly patients. ,
P38 MAPK activation is essential in the NECA-induced signalling cascade that leads to the increase in IL-6 synthesis in U373 MG cells. ,
This proinflammatory cytokine may play important roles in the development of T cell imbalance, cardiovascular disease and wasting in the uremic milieu. (review) ,
Quantitative RT-PCR analysis showed down-regulation by 3.86 and 1.9 for IL-6 and CXCR4 genes, respectively by recombinant erythropoetin ,
Primary thyrocytes express P2YR and P2XR subtypes, coupled to increases in ([Ca(2+)](i)) and secretion of IL-6. ,
These data support the hypothesis that pubertal changes may contribute to accelerated onset of type 1 diabetes in genetically susceptible females. This phenomenon may be orchestrated by the action of estrogen on the IL6 promoter. ,
co-expression of IL-6 and its specific receptor (IL-6Ralpha) in keloid fibroblasts that points to the existence of an IL-6 autocrine loop in these cells ,
IL-6 may reduce estrogen production via the MAPK signal pathway in human granulosa cells ,
Positive association of IL-6 GG genotype with hypertension and elevated plasma PAI-1 in normotensive individuals in Chinese in Taiwan. IL-6 gene promoter G-174C polymorphism may affect regulation of PAI-1 and blood pressure through inflammatory mechanism. ,
IL-6 and OSM upregulate PAI-1 protein and mRNA in adipose tissue ,
IL-17 particularly affects post-transcriptional regulation of IL-8 and IL-6 expression leading to enhanced IL-8 and IL-6 responses to secondary stimuli, and is only a weak proinflammatory stimulus by itself ,
The presence of the C allele in the -174 position in the gene coding for IL-6 could play a role in the pathology of neonatal infection following IAI in the mother and probably is connected with decreased of immunological reaction. ,
CA IX and GLUT 1 as well as VEGF and IL 6 have roles in response of in head and neck squamous cell carcinoma to radiotherapy +/- chemotherapy ,
IL6 is one of the important factors in the pathogenesis of psoriasis. ,
IL-6 may play a role in modulating the inflammatory cascade of chronic periodontitis. ,
Zip14 expression is up-regulated through IL-6 ,
Retinoic acid inhibits CD40 plus IL-4 mediated IgE production through alterations of sCD23, sCD54 and IL-6 production ,
under certain circumstances, acute, pulsatile release of IL-6 does not stimulate synthesis of CRP ,
STAT3 signaling pathway is involved in IL-6-induced neuroendocrine(NE) differentiation and that p38 MAPK is associated with IL-6-stimulated growth regulation in NSCLC-NE cells. ,
IL-6 can induce cell proliferation and neuroendocrine(NE) dedifferentiation but has little effect on chemosensitivity in IL-6 receptor-expressing NSCLC-NE cells. ,
A crystal structure of the ligand-binding domains of gp130 in complex with human interleukin-6 (IL-6) and its a-receptor (IL-6Ralpha). ,
Polymorphisms of IL-6 and TNF-alpha can be used to identify subgroups of patients with higher risk of unsuccessful outcome. ,
That nucleated red blood cell (NRBC) counts were elevated in fetuses delivered for "nonreassuring fetal status" with normal plasma erythropoietin and elevated IL-6 implies that IL-6 may have unique, short-term role in elevating fetal NRBC counts. ,
Results suggest that the interleukin 6-174G/C polymorphism is associated with plasma high-density lipoprotein cholesterol responses to exercise training. ,
IL-6 is a mediator of sleepiness and its circadian pattern reflects the homeostatic drive for sleep ,
different members of the TGF-beta superfamily may also contribute in the reproductive process by enhancing endometrial proimplantatory LIF secretion and reducing proinflammatory IL-6 release by endometrial endothelium ,
The identification of IL-6 and IL-1beta as activators of LT-beta supports their involvement in LT-beta signaling in liver regeneration associated with chronic liver damage. ,
results suggest that interleukin (IL)-6(-174) G/C polymorphism is associated with insulin resistance and increased adipose tissue IL6 gene expression, which can impair adiponectin production ,
IL-6 produced by type I interferon(IFN) dendritic cells controls IFN-gamma production by regulating the suppressive effect of CD4+ CD25+ regulatory T cells. ,
show that IL-6 together with FGF enhanced proliferation of a myeloma cell line, KMS-11 carrying t(4;14)(p16.3;q32) ,
Both white and African Americans carriers of IL6(-237)C had increased risk of spontaneous preterm birth. ,
IL-6 was significantly related with visceral adiposity in obese subjects. ,
SNPs in the promoter region and intron 3 of the IL-6 gene might play a role in the blood pressure regulation and progression of atherosclerosis in the Japanese ,
linkage between the -634C/G marker and bone phenotypes at the spine and the hip ,
IL-6 may have a role in the genesis of neurologic impairment in children born prematurely ,
Polymorphisms associated with control of gene expression and protein levels were not associated with occurrence of chronic idiopaathic leukemia in adults and were not responsible for the increased cytokines. ,
Multiple logistic regression revealed a significant association between the appearance of nucleated RBCs in the blood and erythropoietin, IL-3, IL-6, and age. ,
IL-6 and TNFalpha are involved in the production of HGF by endometrial stromal cells and may be involved in the growth of endometriosis by an autocrine mechanism ,
Data demonstrate a strong association of the -1746>C polymorphism of the IL-6 gene with the aggressiveness and recurrence of prostate cancer ,
investigation of the effect of the IL-6 receptor antagonist Sant7 on proliferative and anti-apoptotic signals in the IL-6-secreting LCL41 B lymphoid cells ,
oxalate up-regulates the expression and secretion of IL-6 in renal epithelial cells ,
We investigated the association of the IL-6 single nucleotide polymorphism (SNP) C-174G with type 2 diabetes in a case-control study of 704 elderly participants of the KORA Survey S4 (1999/2001). ,
gene expression is inhibited by estrogen receptor by disrupting nuclear factor kappaB transactivation ,
C-174G/G genotype of the IL-6 gene may contribute to variations in insulin sensitivity. ,
common genetic variants of CRP (3'UTR 1846C/T) and IL-6 (-174G/C) are significantly associated with the risk of stroke after cardiac surgery and may have a role in inflammation in post-cardiac surgery stroke ,
PAR2 activation stimulates proliferation and interleukin (IL)-6 and IL-8 secretion of endometriotic stromal cells ,
Data suggest that IL-6 --174G>C polymorphism is a clinical marker to identify a subgroup of elderly acute coronary syndrome male patients at higher risk of death. ,
The present study demonstrated that the IL-6R gene expression levels in skeletal muscle are increased in response to acute exercise, a response that is very well conserved, being affected by neither training status nor intramuscular glycogen levels. ,
Promoter variation in IL6 is associated with the risk for serious infection in children undergoing therapy for acute myeloid leukemia ,
Globular adiponectin (gAd) is a powerful inducer of TNF-alpha and IL-6 secretion in primary human peripheral macrophages, in the THP-1 human macrophage cell line, and in primary mouse peritoneal macrophages. ,
IL6 polymorphism was significantly associated with breast cancer. ,
IL-6 was significantly overexpressed in pancreatic specimens and elevated in serum of cachectic patients and represents a prominent cachexia-associated factor in pancreatic cancer. ,
Production of IL-6 and its soluble receptors by stimulated peripheral blood monocytes appears to be inversely correlated with serum cholesterol levels in hemodialysis patients. ,
Data suggest that by inhibiting interleukin (IL)-6 production and lowering plasma IL-6 concentration, high-density lipoproteins may limit the pro-atherogenic effects of both acute and chronic inflammatory states. ,
IL-6-174 G > C polymorphism affects insulin resistance in type 2 diabetes. ,
p38 mitogen-activated protein kinases mediated substance P-induced IL-6 production ,
review of roles for IL-6 in both the resolution of innate immunity and the development of acquired immune responses; the regulatory properties of the soluble IL-6 receptor and how its activity may affect chronic disease progression. ,
two functional promoters regulate the transcriptional expression of PSGR in human prostate tissues, and PSGR is a new target for IL-6 transcriptional regulation ,
the IL-6 -174 genotype mediates growth failure in children with Crohn's disease; those with the IL-6 GG genotype were more growth-retarded than those with the GC or CC genotypes ,
IL-6 174G/C polymorphism may have a role in common carotid artery IMT ,
IL-1beta, IL-6 and TNF-alpha are all significantly increased in hypoxic ischemic encephalopathy infants when compared to controls. ,
The C allele is associated with higher postoperative IL-6 levels and a less favorable clinical outcome. The G-174C polymorphism is related to the outcome after coronary revascularization. ,
Our results indicate that integration of adenoviral DNA and expression of E1A and E1B can either increase or decrease IL-8 production. ,
role for IL-6 in the homeostatic modulation of aqueous humor outflow resistance ,
IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism. ,
the 174 G/C promoter IL-6 polymorphism does not seem to be implicated in susceptibility to and clinical expression of giant cell arteritis ,
no significant association between the IL-6 genotype and risk of coronary heart disease ,
Only women carrying at least one mutant allele of both polymorphisms (tumour necrosis factor-alpha A and interleukin-6 C) have a significantly elevated mean systolic blood pressure and diastolic blood pressure at the end of pregnancy. ,
IL-10, but not TNF-alpha, TNF-beta, or IL-6 polymorphisms are associated with lung cancer ,
Cyclooxygenase-2-dependent activation of STAT3 by interleukin-6 has a role in non-small cell lung cancer ,
Results suggest that the IL-6 genotype associated with intracranial hemorrhage modulates IL-6 expression in brain arteriovenous malformation tissue. ,
acetylation-deacetylation reaction as a novel signaling mechanism controlling the IL-6-STAT3 pathway in the hepatic acute phase response ,
findings suggest that IL-6 directly inhibits hepatocyte proliferation via a p21cip1-dependent mechanism and indirectly enhances hepatocyte proliferation via stimulating nonparenchymal cells to produce HGF ,
IL-6 expression levels were higher in undifferentiated marrow stromal cells (MSCs) than in MSCs treated with osteogenic medium. ,
IL-6 action regulated by variance in the IL-6 gene contributes todevelopment of both type 1 and type 2 diabetes. (review) ,
secretion of IL-6 during day 7 of culture (standardised by taking natural logarithms) was increased markedly by the addition of TNF-alpha ,
GBF1 is recruited to the endogenous IRF-9 promoter, and interacts with C/EBP-beta, IL-1, and IL-6 ,
transforming growth factor, beta 1 and IL-6 might play pivotal but opposing roles in the host tumor interaction ,
A marker of endothelial damage/injury in the activation of vascular and coagulation abnormalities in acute coronary syndromes. ,
Results report changes in the transcriptome profile of HepG2 cells exposed to interleukin (IL)-6 alone, or IL-1beta and IL-6. ,
Multivariate regression analyses showed that lower levels of plasma IL-6 were predicted by greater sleep efficiency ,
A multiple case-control logistic regression associated carriage of il-6 with low CD4 T-cell counts ,
CD30-L/CD30 and IL-6/IL-6R systems could play a major role in the pathogenesis of Graves'disease (GD), but the expression of CD30L/CD30 and IL-6/IL-6R in Hashimoto's thyroiditis (HT) suggests that Th2 mechanisms are involved in tissue damage. ,
a strong induction of the pro-inflammatory cytokine, IL-6, in IL-1-exposed SW1353 cells was found ,
Suramin inhibits TNF-alpha and IL-6 production through the suppression of NF-kappaB activity from macrophages ,
Our present study suggests that serum IL-6 and IL-10 levels are related to fever, and the CSF IL-6 level, myoclonic jerks, in SSPE patients in PNG. ,
interleukin-6 has a role in insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells ,
ST2 negatively regulates LPS-induced IL-6 production via the inhibition of IkappaB degradation in THP-1 cells ,
NEU3 activated by IL-6 exerts IL-6-mediated signaling, largely via the PI3K/Akt cascade, in a positive feedback manner and contributes to expression of a malignant phenotype in renal cell carcinoma ,
Increased interleukin-6 is associated with staging of colorectal cancer ,
Mcl-1 is identified as a mediator of IL-6-induced tumor cell survival and shown to be transcriptionally regulated by IL-6 via a p38 MAPK dependent pathway. ,
The IL-6 concentration increased markedly after 24 h in skin areas irradiated with a twofold minimal erythemal dose (MED) compared to areas challenged repeatedly with 0.3 MED. ,
Findings indicate that IL-6 mRNA translation and degradation are affected by the distortion of the cytoskeleton in airway epithelial cells. ,
These changes in circulating IL-6 were closely associated with a prooxidant state (R2 = 0.47), whereas muscle IL-6 mRNA correlated with an antioxidant state (R2 = 0.65). ,
We conclude that IL-6 triggers VEGF-induced angiogenic activity through increasing VEGF release, up-regulates KDR expression and phosphorylation through activating ERK1/2 signaling, and stimulates MMP-9 overexpression. ,
levels of interleukin-6 & tumor necrosis factor-alpha were significantly higher in patients with fatal Crimean-Congo hemorrhagic fever (CCHF)than nonfatal CCHF; findings demonstrate that proinflammatory cytokines play a major role in the mortality in CCHF ,
salivary levels seem not to play a role in recurrent aphthous ulcer disease ,
there are tissue-specific differences in IL-6-receptor-gp130-coupled signaling which limit the extent of Stat3 activation and gammaFBG expression during lung inflammation ,
IL-6 and IL-8 production by human articular chondrocytes is vitro are stimulated by histamine exposure, this being mediated bia the H1R pathway ,
IL-6 and IL-8 are associated with postoperative surgical site infection, including pancreatic leakage after pancreaticoduodenectomy. ,
The results suggest that both IL-6 and GH may play a role in the progression of both endometriosis and endometrial carcinoma. ,
analysis of interleukin-6 response to elective total hip replacement surgery ,
The IL-6 -174 G/C, IL-10 -1082 G/A and CD14 -260 C/T SNPs may alter risk for sepsis in ventilated VLBW infants ,
An IL-6-CD44 feedback loop in macrophages may aggravate atherosclerosis development. ,
circulating IL-6 may have a role in acute stroke ,
there is no association between the common polymorphisms in IL6 gene and circulating IL-6 levels and the risk of type 2 diabetes ,
During exercise, with and without carbohydrate ingestion, plasma IL-6 increased. The concentration of IL-6 in CSF did not change with exercise and was below the plasma levels. ,
This is the first study to show that IL-6 promoter polymorphisms are associated with intracranial aneurysmal dise ,
macrophages may be a major source of IL-6 in the gastric mucosa upon H. pylori infection. The IL-6 induction by H. pylori in these cells is a multifactorial process, which requires the uptake and presumably degradation of H. pylori bacteria. ,
sIL-2R and IL-6, but not IL-2, IL-4, or IL-10, may have a role in preventing progression of aggressive non-Hodgkin's lymphoma ,
data suggest that the IL-6 G-174 C polymorphism does not seem to play a role in breast cancer risk, although its role as a prognostic factor remains to be studied ,
IL-6 and Stat3 binding induces BCL3 ,
The release of IL-6 from peripheral tissues may act as a signal for the inflammatory response and contribute to functional dysregulation in uremia. ,
Interleukin 6 is an independent factor that is associated with C-reactive protein in Japanese type 2 diabetic patients. ,
Further analyses show that inhibitors of phosholipase D, Rho, and protein kinase C also inhibited the LPL-induced release of IL-6 and IL-8. ,
IL-6 level in tumor cells is not a predictive marker for response to paclitaxel in women with metastatic breast cancer. ,
Polymorphisms of IL-6 were not associated with outcomes in acute coronary disease patients. ,
present study provides the epidemiological evidence that IL-6 is one of the main correlates of low HDL-C levels in older individuals ,
Pre-B cell colony-enhancing factor (PBEF) is regulated via IL-6 trans-signaling and the IL-6-related cytokine OSM. PBEF is also actively expressed during arthritis. ,
IL-6 is associated in a reciprocal manner with the two pathophysiological components of type 2 diabetes, insulin resistance and insulin secretion. ,
IL-6 promoter polymorphism -174 is associated with new-onset diabetes after transplantation. ,
The results suggest that IL-6 plays a role in the GH-->IGF-I response to intense exercise. ,
Although there are still missing links to it, our results support the concept that high concentrations of glucocorticoids, met in critically ill patients, prevent TNF-alpha- and LPS-stimulated IL-6 secretion. ,
TLR2, IL-6 and IL-1beta may have roles in inflammatory reactions in the course of Lyme disease ,
IL-2 and IL-6 in saliva may have roles in development of burning mouth syndrome ,
serum IL-1beta and TNF-alpha are increased, and IL-2 and IL-6 are decreased in newly diagnosed IDDM patients ,
IL-8 and IL-6 may have roles in development of psoriasis ,
induction of IL-6 secretion from T cells by thrombin, trypsin and tryptase is probably through the activation of Proteinase-activated receptors, suggesting that serine proteinases are involved in the regulation of immune response of the body. ,
Carriers of the IL-6 appeared to have an increased risk of stroke in association with a febrile episode prior to strokes. ,
Has direct effects upon endothelial cells, inhibiting endothelial nitric oxide synthase expression in part through Stat3. ,
The selective increase in sIL-6R implicates an enhanced trans-signaling capacity whereby sleep distinctly widens the profile of IL-6 actions, enabling an integrated influence on brain and peripheral organs ,
There are associations between sudden infant death syndrome and particular polymorphisms. ,
Evidence suggests a direct role for IL-6 in muscle cell destruction and a possibility of muscle cell damage via an autocrine fashion. ,
IL-; Gene Polymorphism confers susceptibility to PH in patients with COPD. ,
PDTC downregulates IL-6-induced STAT3 activation by altering the stability of STAT3-Hsp90 complex ,
IL-6 -634C/G and ICAM-1 469K/E polymorphisms synergistically affect the susceptibility for endometriosis in the Japanese population. ,
Adiponectin-mediated induction of IL-6, CCL2 and CXCL8 is disturbed in monocytes from type I diabetes patients. ,
Impaired glucose tolerance and type 2 diabetes, but not impaired fasting glucose are associated with elevated plasma IL-6 levels. ,
These results indicate that AUF1 binds to the AU-rich element in vivo and promotes IL-6 mRNA degradation. ,
Data show that the gene expression for interleukin-8, IL-10, and IL-1Ra, but not IL-6, is increased in blood leukocytes taken from athletes following 2 hours of intensive cycling and is not influenced by carbohydrate compared with placebo ingestion. ,
The -174 IL-6 promoter polymorphism modifies the association of obesity with IR and diabetes risk in men. ,
Medroxyprogesterone acetate and danazol appeared to have a decreased effect on the suppression of IL-6 liberated by ESCs in adenomyosis. ,
A case of parotid myoepithelioma occurred in a patient affected by myasthenia gravis supports a possible IL-6 mediated relationship between myasthenia gravis and parotid myoepithelioma. ,
Pro-inflammatory cytokines derived from surgical trauma may enhance tumor cell adhesion to microvascular endothelial cells and thus bring about more successful tumor cell implantation resulting in an increased risk of metastasis formation. ,
The GC and CC genotypes of IL6 -174G>C were associated with a decreased risk of type 2 diabetes (odds ratio 0.91, P = 0.037), corresponding to a risk modification of nearly 9%. ,
An elevated preoperative C-reactive protein was associated with increased tumour stage, interleukin-6 and interleukin-10 concentrations. ,
alpha-synuclein strongly stimulates human astrocytes as well as human U-373 MG astrocytoma cells to up-regulate both interleukin IL-6 and ICAM-1; mutated forms are more potent stimulators than wild-type ,
mutual link between the post-coronary artery bypass grafting (CABG) major adverse cardiovascular events (MACE) incidence, the - 174G > C IL6 polymorphism and past acute infections history ,
Results indicate a direct regulatory effect of IL-6 genotypes in the determination of 60-kDa heat-shock protein autoantibody levels. ,
The early induction of IP-10 and IL-2, as well as the subsequent over-production of IL-6 and lack of IL-10 production, probably contribute to the main immuno-pathological processes involved in lung injury in SARS. ,
An association between the IL6 G-174C polymorphism and Australian SIDS infants was observed. ,
TGF-beta1 activates IL-6 production, and the functional interaction between TGF-beta1 and IL-6 contributes to intrahepatic cholan-giocarcinoma (ICC) cell growth by TGF-beta1. ,
Periodontal tissue destruction and local synthesis are associated with elevated serum levels in transplant recipients ,
Our results demonstrate NFAT expression and activation in native human vessels and point out A-285222 as a powerful pharmacological blocker of NFAT signaling in the vasculature. ,
haplotypes of IL6 (-660G/-635C/-236G) and IL10 (-6653C/-1116G) were significantly associated with HTLV-I infection in children independent of maternal provirus load and duration of breast-feeding ,
analyzed the expression of Toll-like receptors 1 to 9 on myeloid dendritic cells generated from X-linked agammaglobulinemia patients and evaluated their response to activation by specific Toll-like receptor agonists ,
Polymorphisms of TNF-alpha, IFN-gamma, TGF-beta1, IL-10 and IL-6 do not appear to influence the onset of broncholitis obliterans syndrome or graft survival in recipients. ,
relationships of IL-6 with components of the IGF system in the placenta and newborn infant ,
The biliary IL-6 and TNF-alpha levels were positively correlated with serum DBIL, TBA and gamma-GT levels in infantile hepatitis syndrome subjects. ,
In heart transplant patients, high levels of serum IL6 were associated with low grade cellular rejection. ,
Interleukin-6 single nucleotide polymorphism (SNP) IL6(-174) association with severe carotid artery disease is confirmed. ,
There were no statistically significant differences in IL-6 and IL-8 gene polymorphisms between the SLE and control groups (chi-squared test, P=0.53, chi(2)=1.27 and P=0.44, chi(2)=1.62, respectively). ,
IL-6 promoter genotypes may be associated with increased risk of plasma cell neoplasms ,
Histamine stimulates IL-6 release from SW982 cells by binding to the H1 receptor and this is coupled to the PI/PKC signal transduction pathway. ,
The association of this gene variant of IL-6 with the metabolic syndrome is intimately linked with obesity per se. ,
This preliminary study is the first to suggest that the TGF-beta1 signal sequence (29T-->C) and IL-6 promoter (-597G-->A)|(-572G-->C) transitions are predictive for the time to onset of aseptic instability after total hip arthroplasty ,
patients with a transient increase in IL-6 in response to IFN-beta showed a slow disease progression ,
CD37 is important for dectin-1 stabilization in APC membranes and controls dectin-1-mediated IL-6 production. ,
BRG1 is constitutively present at IL-6-responsive promoters and is required for STAT3 recruitment, downstream histone modifications, and IL-6-induced chromatin remodeling. ,
aneurysms secrete IL-6 into the circulation ,
Serum levels of IL-6 were increased in Down's syndrome (DS) children and adults, but not in older DS patients. ,
interleukin-6 induces Oct-1 gene expression, providing a biologically relevant means by which NF-kappaB-dependent gene expression can be selectively reverted by Oct-1 to quiescent levels ,
The hypothalamic-pituitary-adrenal (HPA) axis and the proinflammatory cytokines (and interleukin-6 [IL-6] in particular) are enmeshed in the response to somatic stress ,
The maternal side of term placentas secreted significantly higher amounts of interleukin (IL)-6 compared with preterm placentas. Exposure to LPS significantly decreased IL-6 secretion from the maternal side in both term and preterm placentas. ,
possibility that the IL-6 mediated androgen-independent proliferation of PC-3 and DU145 prostate cancer cells is regulated at least partly via SAPKs signaling pathway especially through p38MAPK activation. ,
higher risk in ESRD patients with low IL-4 and high IL-6 producing genotypes ,
The -174IL-6 single-nucleotide polymorphism are associated with susceptibility to chronic periodontitis in the population studied. ,
keratin-8 has a role in interleukin-6-induced barrier function alterations ,
let-7a modulates interleukin-6-dependent STAT-3 survival signaling in malignant human cholangiocytes ,
The mucosa of esophagitis patients produced significantly greater amounts of IL-1beta and IL-6 compared with those of control patients ,
SOCS-3 epigenetic silencing is responsible for sustained IL-6/STAT-3 signaling and enhanced Mcl-1 expression in cholangiocarcinoma ,
IL6 down-regulated CD33, CD7, or CD56 expression in primary myeloma cells, as well as in Liu01 cells ,
Recombinant human IL-6-treated neural Paju cells upregulate stanniocalcin-1 expression via MAP kinase signaling. ,
the increased expression of IL-6 and IL-6 (-174) polymorphism are associated with periodontal disease severity in Brazilian individuals ,
IL-6 concentration seems to be a more specific marker of liver metastasis. ,
IL-6 can directly influence cell proliferation and the invasion potential as the first step of tumor metastasis. ,
BMP pathway regulates IL-6 in pulmonary tissues and conversely that IL-6 regulates the BMP pathway ,
Single nucleotide polymorphism in IL-6 is associated with cardiovascular diseases ,
The polymorphism of IL-6 may at least partially explain the genetic predisposition to an aggressive course of the disease with the development of terminal stage. ,
Elevated IL-6 levels occur in connection with bacterial infections after kidney transplantation. ,
The transition of IL-6 from a paracrine growth inhibitor to an autocrine growth stimulator suggests that IL-6 plays an important role during prostate cancer progression, possibly androgen-independent progression. ,
Increasing the protein levels of the signal transducer and activator of transcription 3 (Stat3) led to Stat3-androgen receptor (AR) complex formation in response to epidermal growth factor (EGF) and interleukin-6 (IL-6) stimulation. ,
CCL2 mediates fibroblast survival by inhibiting apoptosis through IL-6/STAT3 signaling ,
Circulating IL-6 is linked to endothelial dysfunction independently of insulin sensitivity in apparently healthy men. ,
higher "stress index" was associated with higher expression of total LPS-stimulated TNF-alpha and IL-6 between rest and 60min post-stress ,
the lung epithelial cell is a possible target of dengue viruses and IL-6 and RANTES may play pivotal roles in lung related immuno-pathogenesis ,
both splanchnic organs and kidneys affect in a significant way the disposal of IL-6 in humans ,
the polymorphism in IL-6 gene promoter (-174 G/C) does not appear to be a genetic risk factor for Henoch-Schonlein pur-pura in Northwest Spain. ,
polymorphic variations of pro-inflammatory cytokines play an important role in susceptibility to multiple sclerosis ,
This study demonstrated a significant association between CSF levels of IL-1beta, Il-6, and IFN-gamma and the severity ot EV71 brain stem encephalitis. ,
the median serum concentration of IL-6 had a significant positive correlation with the liver dysfunction biological markers and vitamin B12 ,
an evident association exists between the carriage of the GG genotype and the extent periodontal disease ,
Intermittent hypoxia increases IL-6, improving aerobic fitness and minimizing the risk of thromboimflammation. ,
capacity of bladder cells to mobilize secondary messengers and evoke a more rapid IL-6 response via TLR4 protein might be critical in their role as first responders to microbial challenge ,
Inhibition of ERK phosphorylation decreased expression of IL6. ,
IL-6 receptor activation may have a role in the pathogenesis of arteriovenous fistula failure in hemodialysis patients. ,
Transcription factors glucocorticoid receptor, STAT-3, and HNF-1alpha bind to the angiotensinogen gene promoter mediating IL-6 induced promoter activity of this gene. ,
Immunohistochemical analyses revealed plasma cells in the synovial lining of the high producers as the source of IL-6 in osteoarthritis ,
Il-6 and matrix metalloproteinase-9 provide a link between inflammation, matrix degradation and the development/progresion of acute coronary syndrome. ,
Results showed that the viral nucleocapsid (N) protein activated IL-6 expression in a concentration-dependent manner; promoter analyses suggested that NF-kappaB binding element was required for IL-6 expression regulated by N protein. ,
In Hodgkin's lymphoma Carriers of the IL-6-174GG genotype had a significantly lower probability of freedom from treatment failure ,
in peripheral blood mononuclear cells, C5a activates the p38 cascade, and this pathway plays a major role in the C5a enhancement of LPS-induced IL-6 and TNF-alpha production ,
main finding of the present study is that the -174C/G polymorphism is not associated with sudden infant death syndrome in Norway ,
elevated spontaneous production of IL-6 in patients with major depression ,
Interleukin-6 (IL-6) was expressed in monocytes and B cells, IL-10 in monocytes, and suppressor of cytokine signaling 3 in monocytes and T cells from patients with active disease. ,
Sequestration of the interleukin-6 (IL-6) ligand led to a decrease of phosphorylated Stat3 levels in breast cancer. ,
Down regulation of HuR expression by siRNA prevents atazanavir-induced increase of TNF-alpha and IL-6, suggesting that HuR might have an impact on pathophysiological processes of HIV PI-induced atherosclerosis ,
Our results indicate that IL-6 expression is regulated through NF-kappaB transcription factor and stereoid-receptor signalling pathways in ARPE-19 cells. ,
These results suggest that IL-10 and IL-6 gene polymorphisms may affect susceptibility to Brucellosis and increase risk of developing the disease. ,
We observed an association between GG allele of IL6 on -174 base with gastric cancer. ,
IL-6 may have a potential role as a mediator between cardiovascular risk factors and several biological mechanisms for cardiovascular disease ,
IL-6 was elevated in colostrum of mothers of neonates with jaundice. ,
Staphylococcal enterotoxin C1 may act through an NADPH oxidase mechanism to release reactive oxygen species ,
changes in IL-6 mRNA expression in open discectomy and microendoscopic disectomy groups varied significantly at 1 h, 12 h post-op, 10.26-fold versus 4.42-fold and 52.15-fold versus 26.78-fold increase, respectively ,
IL6 gene is significantly associated with adiposity. ,
IL-6 -174 G/C polymorphism is not associated with the risk of premature CAD, and does not contribute to cardiovascular risk stratification. ,
A higher gene expression of CRP, IL-6, and both IL-6 membrane receptors in subcutaneous samples of inflamed patients than in healthy controls. ,
IL-6 levels significantly increased following the mental calculation stress test in ulcerative colitis patients compared with in the volunteers ,
This study investigated whether the single nucleotide polymorphism (SNP) in the promoter region of the IL-6 gene is associated with a development of chronic glomerulonephritis. ,
IL-6 and IL-10 genotypes may be useful in predicting disease severity in autoantibody-positive and autoantibody-negative rheumatoid arthritis patients, respectively. ,
Azithromycin suppressed NF-kappaB activation and reduced synthesis of IL6/IL8 in tracheal cells from preterm ventilated infants. ,
Response rates to HCV-specific treatment are higher in HCV/HIV-positive patients carrying the IL-6 HP genotype, which might be because of IL-6 mediated STAT3 activation. ,
The secretory levels of PGE(2), TXB(2) and IL-6 were highest in ruptured abdominal aortic aneurysms and statistically higher than those in intact abdominal aortic aneurysms. ,
Among older adults free of clinical cardiovascular disease specific IL-6 promoter appeared to confer positive associations of alcohol consumption with IL-6 concentrations ,
IL-6 plays a role in the development and progression of atherosclerosis. ,
IL-6 homozygous genotypes were significantly more often detected in oral lichen planus patients. ,
septic plasma permanently suppressed the production of IL-6 and IL-10 in stimulated whole blood. ,
norepinephrine stimulation activates Src tyrosine kinase and this activation is required for increased IL-6 expression ,
The impact of the IL6 -634G allele on serum C-reactive protein elevation is greater in nonsmokers than in current smokers. ,
IL-6-dependent mechanisms controlling L-selectin adhesion are conserved over hundreds of millions of years of vertebrate evolution as a beneficial focal point regulating immune surveillance during febrile inflammatory responses. ,
Cervical IL-6 and IL-8 might have predictive value for cases of recurrent miscarriage. ,
polymorphism not associated with an increased risk of benign migratory glossitis development ,
A novel observation of genetic predisposition to systemic inflammatory response syndrome, sepsis and septic shock is associated with a polymorphism in the IL-6 gene. ,
In long-lasting persistent AF, lower levels of IL-6 appear to be associated with maintenance of sinus rhythm after pharmacological cardioversion irrespective of the use of RAS inhibitors ,
Significant elevation of IL-6 in blood and bronchoalviolar lavage during the first few hours after reperfusion of the graft was related to developed of primary graft dysfunction. ,
Analyzing inflamed specimens from UC patients compared with control samples, interleukin (IL)-6 was sharply the most induced cytokine. Similar results were found in activated PBLs; IL-6 was confirmed to be the most induced. ,
Disturbed sleep during pregnancy is associated with increased levels of IL-6. ,
CHROMOSOME
7,
ENTREZ_GENE_ID
3569 ,
541472 ,
PIR_SUMMARY
IL-6 is a cytokine with a wide variety of biological functions: it plays an essential role in the final differentiation of B-cells into Ig-secreting cells, it induces myeloma and plasmacytoma growth, it induces nerve cells differentiation, in hepatocytes it induces acute phase reactants.,
UNIGENE
Hs.512234 ,
Hs.654458 ,
PIR_NREF_ID
NF00088566,
NF00094150,
NF00127206,
NF00989305,
UNIREF100_ID
UniRef100_P05231 ,
UNIPROT_ID
IL6_HUMAN ,
Q75MH2_HUMAN ,
Q8N6X1_HUMAN ,
CYTOBAND
7p21,
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