SOOD SK, WORMSER GP; Interscience Conference on Antimicrobial Agents and Chemotherapy (42nd : 2002 : San Diego, Calif.).
Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 2002 Sep 27-30; 42: abstract no. 1761.
North Shore Univ. Hosp, Manhasset, NY.
The prevalence of deer ticks and the incidence of Lyme disease are increasing steadily. Infectious Disease practitioners need to be familiar with new information on clinical characteristics, treatment choices and prognosis of Lyme disease, which has been generated in studies of microbiologically and serologically confirmed disease. Highlights include lack of central clearing in most erythema migrans rashes, and the absence of long-term sequelae in the vast majority of treated patients. New information on the diversity of B. burgdorferi strains by surface protein subtypes has enhanced our understanding of why only some bites result in disseminated disease. Recently marketed or investigational diagnostic tests should be viewed in the context of existing reliable immunoblot technology. The recombinant OspA vaccine, while safe and efficacious, was recently discontinued, but practitioners should be familiar with the safety data and the longevity of protection in immunized persons. The current preventive strategy is based upon tick identification and consideration of antibiotic prophylaxis with doxycycline, keeping in mind the high incidence of side-effects and that most ticks do not transmit the spirochete, even in highly endemic areas. The World Wide Web is a resource for Infectious Disease practitioners that can be used effectively, but is also a source of misinformation for our patients.
Publication Types:
Keywords:
- Animals
- Antibiotic Prophylaxis
- Bites and Stings
- Doxycycline
- Glossitis, Benign Migratory
- Humans
- Incidence
- Ixodes
- Lyme Disease
- Lyme Disease Vaccines
- Spirochaeta
- Ticks
Other ID:
UI: 102267344
From Meeting Abstracts