EFFECT OF INSULIN ON CARBOHYDRATE METABOLISM AND ON POTASSIUM IN THE FOREARM OF MAN

doi:10.1172/JCI104452

J Clin Invest. 1962 January; 41(1): 108–115.

doi: 10.1172/JCI104452.

PMCID: PMC289199

EFFECT OF INSULIN ON CARBOHYDRATE METABOLISM AND ON POTASSIUM IN THE FOREARM OF MAN^*

Reubin Andres, Marcel A. Baltzan, Gordon Cader, and Kenneth L. Zierler

Department of Medicine, The Johns Hopkins University and Hospital, and The Baltimore City Hospitals, Baltimore, Md.

^* These studies were aided by Contract Nonr-248(34) (NR 101-241) between the Office of Naval Research, Department of the Navy, and The Johns Hopkins University; by Public Health Service Research Grant A-750, National Institute of Arthritis and Metabolic Diseases; and by a grant-in-aid from the Muscular Dystrophy Associations of America, Inc. Reproduction in whole or in part is permitted for any purpose of the United States Government.

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ANDRES, R; CADER, G; ZIERLER, KL. The quantitatively minor role of carbohydrate in oxidative metabolism by skeletal muscle in intact man in the basal state; measurements of oxygen and glucose uptake and carbon dioxide and lactate production in the forearm. J Clin Invest. 1956 Jun;35(6):671–682. [PubMed]
ANDRES, R; ZIERLER, KL; ANDERSON, HM; STAINSBY, WN; CADER, G; GHRAYYIB, AS; LILIENTHAL, JL., Jr Measurement of blood flow and volume in the forearm of man; with notes on the theory of indicator-dilution and on production of turbulence, hemolysis, and vasodilatation by intra-vascular injection. J Clin Invest. 1954 Apr;33(4):482–504. [PubMed]
McCANN, WP; JUDE, JR. The synthesis of glucose by the kidney. Bull Johns Hopkins Hosp. 1958 Aug;103(2):77–93. [PubMed]
BRUNS, FH; HORN, HD. Quantitative Bestimmung von L(+)-Milchsäure mit Milchsäuredehydrogenase. Biochim Biophys Acta. 1956 Aug;21(2):378–380. [PubMed]
YALOW, RS; BERSON, SA. Immunoassay of endogenous plasma insulin in man. J Clin Invest. 1960 Jul;39:1157–1175. [PubMed]
Nakamura, H. The oxygen use of muscle and the effect of sympathetic nerves on it. J Physiol. 1921 May 24;55(1-2):100–110. [PubMed]
Pappenheimer, JR. Blood flow, arterial oxygen saturation, and oxygen consumption in the isolated perfused hindlimb of the dog. J Physiol. 1941 Mar 25;99(3):283–303. [PubMed]
HARDWICK, C; BUTTERFIELD, WJ; FRY, IK; BRIGGS, JH. Direct measurement of the effect of insulin on the uptake of glucose by peripheral muscles in normal subjects, diabetics and acromegalics. Proc R Soc Med. 1959 Oct;52:807–812. [PubMed]
BUTTERFIELD, WJ; HOLLING, HE. Peripheral glucose metabolism in fasting control subjects and diabetic patients. Clin Sci. 1959 May;18:147–174. [PubMed]
ANDRES, R; CADER, G; GOLDMAN, P; ZIERLER, KL. Net potassium movement between resting muscle and plasma in man in the basal state and during the night. J Clin Invest. 1957 May;36(5):723–729. [PubMed]
MACKLER, B; LICHTENSTEIN, H; GUEST, GM. Effects of ammonium chloride acidosis on the action of insulin in dogs. Am J Physiol. 1951 Jul;166(1):191–198. [PubMed]
BELL, DM; BURNS, T. Effect on femoral A-V glucose difference of insulin injected into an antecubital vein and into a femoral artery. J Clin Invest. 1952 Jul;31(7):717–720. [PubMed]
FRENCH, EB; KILPATRICK, R. The role of adrenaline in hypoglycaemic reactions in man. Clin Sci (Lond). 1955 Nov;14(4):639–651. [PubMed]
ALLWOOD, MJ; GINSBURG, J; PATON, A. The effect of insulin hypoglycaemia on blood flow in intact and sympathectomized extremities in man. J Physiol. 1957 Nov 14;139(1):97–107. [PubMed]
BUTTERFIELD, J; FRY, IK; HOLLING, E. Effects of insulin, tolbutamide and phenethyldiguanidine on peripheral glucose uptake in man. Diabetes. 1958 7(6):449–454.Nov–Dec; [PubMed]
ZIERLER, KL. Effect of insulin on membrane potential and potassium content of rat muscle. Am J Physiol. 1959 Sep;197:515–523. [PubMed]
ZIERLER, KL. Effect of insulin on potassium efflux from rat muscle in the presence and absence of glucose. Am J Physiol. 1960 May;198:1066–1070. [PubMed]