NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 Facility: Battelle Columbus Laboratory Chemical CAS #: 103-90-2 Lock Date: 09/30/03 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 1 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 1 ANIMAL NUM: 125 DOSE: 0 MG/KG 6 HR DISP: Terminal Sacrifice HISTO: 0203112 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL * Kidney Liver Lft Lobe Liver Med Lobe * PROTOCOL REQUIRED TISSUE __________________________________________________________________________________________________________________________________ Page 2 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 1 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 1 ANIMAL NUM: 126 DOSE: 0 MG/KG 6 HR DISP: Terminal Sacrifice HISTO: 0203113 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL * Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 3 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 1 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 1 ANIMAL NUM: 127 DOSE: 0 MG/KG 6 HR DISP: Terminal Sacrifice HISTO: 0203114 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL * Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 4 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 1 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 1 ANIMAL NUM: 137 DOSE: 0 MG/KG 6 HR DISP: Terminal Sacrifice HISTO: 0203124 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL * Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 5 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 1 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 1 ANIMAL NUM: 138 DOSE: 0 MG/KG 6 HR DISP: Terminal Sacrifice HISTO: 0203125 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL * Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 6 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 1 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 1 ANIMAL NUM: 139 DOSE: 0 MG/KG 6 HR DISP: Terminal Sacrifice HISTO: 0203126 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL * Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 7 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 2 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 128 DOSE: 0 MG/KG 18 HR DISP: Terminal Sacrifice HISTO: 0203115 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL * Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 8 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 2 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 129 DOSE: 0 MG/KG 18 HR DISP: Terminal Sacrifice HISTO: 0203116 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL * Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 9 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 2 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 130 DOSE: 0 MG/KG 18 HR DISP: Terminal Sacrifice HISTO: 0203117 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL * Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 10 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 2 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 140 DOSE: 0 MG/KG 18 HR DISP: Terminal Sacrifice HISTO: 0203127 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL * Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 11 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 2 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 141 DOSE: 0 MG/KG 18 HR DISP: Terminal Sacrifice HISTO: 0203128 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL * Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 12 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 2 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 142 DOSE: 0 MG/KG 18 HR DISP: Terminal Sacrifice HISTO: 0203129 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL * Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 13 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 3 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 131 DOSE: 0 MG/KG 24 HR DISP: Terminal Sacrifice HISTO: 0203118 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL * Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 14 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 3 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 132 DOSE: 0 MG/KG 24 HR DISP: Terminal Sacrifice HISTO: 0203119 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL * Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 15 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 3 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 133 DOSE: 0 MG/KG 24 HR DISP: Terminal Sacrifice HISTO: 0203120 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL * Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 16 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 3 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 143 DOSE: 0 MG/KG 24 HR DISP: Terminal Sacrifice HISTO: 0203130 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL * Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 17 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 3 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 144 DOSE: 0 MG/KG 24 HR DISP: Terminal Sacrifice HISTO: 0203131 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL * Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 18 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 3 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 145 DOSE: 0 MG/KG 24 HR DISP: Terminal Sacrifice HISTO: 0203132 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL * Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 19 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 4 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 3 ANIMAL NUM: 134 DOSE: 0 MG/KG 48 HR DISP: Terminal Sacrifice HISTO: 0203121 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL * Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 20 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 4 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 3 ANIMAL NUM: 135 DOSE: 0 MG/KG 48 HR DISP: Terminal Sacrifice HISTO: 0203122 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL * Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 21 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 4 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 3 ANIMAL NUM: 136 DOSE: 0 MG/KG 48 HR DISP: Terminal Sacrifice HISTO: 0203123 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL * Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 22 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 4 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 3 ANIMAL NUM: 146 DOSE: 0 MG/KG 48 HR DISP: Terminal Sacrifice HISTO: 0203133 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL * Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 23 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 4 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 3 ANIMAL NUM: 147 DOSE: 0 MG/KG 48 HR DISP: Terminal Sacrifice HISTO: 0203134 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL * Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 24 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 4 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 3 ANIMAL NUM: 148 DOSE: 0 MG/KG 48 HR DISP: Terminal Sacrifice HISTO: 0203135 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL * Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 25 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 5 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 1 ANIMAL NUM: 225 DOSE: 50 MG/KG6 HR DISP: Terminal Sacrifice HISTO: 0203136 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL * Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 26 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 5 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 1 ANIMAL NUM: 226 DOSE: 50 MG/KG6 HR DISP: Terminal Sacrifice HISTO: 0203137 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL * Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 27 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 5 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 1 ANIMAL NUM: 227 DOSE: 50 MG/KG6 HR DISP: Terminal Sacrifice HISTO: 0203138 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL * Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 28 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 5 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 1 ANIMAL NUM: 237 DOSE: 50 MG/KG6 HR DISP: Terminal Sacrifice HISTO: 0203148 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL * Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 29 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 5 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 1 ANIMAL NUM: 238 DOSE: 50 MG/KG6 HR DISP: Terminal Sacrifice HISTO: 0203149 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL * Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 30 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 5 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 1 ANIMAL NUM: 239 DOSE: 50 MG/KG6 HR DISP: Terminal Sacrifice HISTO: 0203150 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL * Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 31 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 6 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 228 DOSE: 50 MG/KG18 HR DISP: Terminal Sacrifice HISTO: 0203139 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 32 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 6 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 229 DOSE: 50 MG/KG18 HR DISP: Terminal Sacrifice HISTO: 0203140 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 33 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 6 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 230 DOSE: 50 MG/KG18 HR DISP: Terminal Sacrifice HISTO: 0203141 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 34 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 6 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 240 DOSE: 50 MG/KG18 HR DISP: Terminal Sacrifice HISTO: 0203151 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 35 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 6 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 241 DOSE: 50 MG/KG18 HR DISP: Terminal Sacrifice HISTO: 0203152 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 36 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 6 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 242 DOSE: 50 MG/KG18 HR DISP: Terminal Sacrifice HISTO: 0203153 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 37 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 7 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 231 DOSE: 50 MG/KG24 HR DISP: Terminal Sacrifice HISTO: 0203142 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 38 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 7 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 232 DOSE: 50 MG/KG24 HR DISP: Terminal Sacrifice HISTO: 0203143 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 39 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 7 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 233 DOSE: 50 MG/KG24 HR DISP: Terminal Sacrifice HISTO: 0203144 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 40 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 7 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 243 DOSE: 50 MG/KG24 HR DISP: Terminal Sacrifice HISTO: 0203154 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 41 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 7 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 244 DOSE: 50 MG/KG24 HR DISP: Terminal Sacrifice HISTO: 0203155 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 42 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 7 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 245 DOSE: 50 MG/KG24 HR DISP: Terminal Sacrifice HISTO: 0203156 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 43 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 8 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 3 ANIMAL NUM: 234 DOSE: 50 MG/KG48 HR DISP: Terminal Sacrifice HISTO: 0203145 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 44 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 8 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 3 ANIMAL NUM: 235 DOSE: 50 MG/KG48 HR DISP: Terminal Sacrifice HISTO: 0203146 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 45 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 8 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 3 ANIMAL NUM: 236 DOSE: 50 MG/KG48 HR DISP: Terminal Sacrifice HISTO: 0203147 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 46 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 8 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 3 ANIMAL NUM: 246 DOSE: 50 MG/KG48 HR DISP: Terminal Sacrifice HISTO: 0203157 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 47 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 8 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 3 ANIMAL NUM: 247 DOSE: 50 MG/KG48 HR DISP: Terminal Sacrifice HISTO: 0203158 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 48 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 8 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 3 ANIMAL NUM: 248 DOSE: 50 MG/KG48 HR DISP: Terminal Sacrifice HISTO: 0203159 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 49 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 9 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 1 ANIMAL NUM: 325 DOSE: 150MG/KG6HR DISP: Terminal Sacrifice HISTO: 0203160 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 50 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 9 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 1 ANIMAL NUM: 326 DOSE: 150MG/KG6HR DISP: Terminal Sacrifice HISTO: 0203161 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 51 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 9 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 1 ANIMAL NUM: 327 DOSE: 150MG/KG6HR DISP: Terminal Sacrifice HISTO: 0203162 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 52 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 9 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 1 ANIMAL NUM: 337 DOSE: 150MG/KG6HR DISP: Terminal Sacrifice HISTO: 0203172 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 53 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 9 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 1 ANIMAL NUM: 338 DOSE: 150MG/KG6HR DISP: Terminal Sacrifice HISTO: 0203173 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 54 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 9 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 1 ANIMAL NUM: 339 DOSE: 150MG/KG6HR DISP: Terminal Sacrifice HISTO: 0203174 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 55 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 10 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 328 DOSE: 150MG/KG18 HR DISP: Terminal Sacrifice HISTO: 0203163 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 56 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 10 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 329 DOSE: 150MG/KG18 HR DISP: Terminal Sacrifice HISTO: 0203164 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 57 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 10 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 330 DOSE: 150MG/KG18 HR DISP: Terminal Sacrifice HISTO: 0203165 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 58 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 10 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 340 DOSE: 150MG/KG18 HR DISP: Terminal Sacrifice HISTO: 0203175 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 59 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 10 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 341 DOSE: 150MG/KG18 HR DISP: Terminal Sacrifice HISTO: 0203176 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 60 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 10 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 342 DOSE: 150MG/KG18 HR DISP: Terminal Sacrifice HISTO: 0203177 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 61 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 11 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 331 DOSE: 150MG/KG24 HR DISP: Terminal Sacrifice HISTO: 0203166 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 62 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 11 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 332 DOSE: 150MG/KG24 HR DISP: Terminal Sacrifice HISTO: 0203167 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 63 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 11 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 333 DOSE: 150MG/KG24 HR DISP: Terminal Sacrifice HISTO: 0203168 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 64 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 11 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 343 DOSE: 150MG/KG24 HR DISP: Terminal Sacrifice HISTO: 0203178 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 65 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 11 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 344 DOSE: 150MG/KG24 HR DISP: Terminal Sacrifice HISTO: 0203179 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 66 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 11 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 345 DOSE: 150MG/KG24 HR DISP: Terminal Sacrifice HISTO: 0203180 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 67 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 12 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 3 ANIMAL NUM: 334 DOSE: 150MG/KG48 HR DISP: Terminal Sacrifice HISTO: 0203169 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 68 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 12 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 3 ANIMAL NUM: 335 DOSE: 150MG/KG48 HR DISP: Terminal Sacrifice HISTO: 0203170 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 69 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 12 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 3 ANIMAL NUM: 336 DOSE: 150MG/KG48 HR DISP: Terminal Sacrifice HISTO: 0203171 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 70 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 12 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 3 ANIMAL NUM: 346 DOSE: 150MG/KG48 HR DISP: Terminal Sacrifice HISTO: 0203181 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 71 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 12 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 3 ANIMAL NUM: 347 DOSE: 150MG/KG48 HR DISP: Terminal Sacrifice HISTO: 0203182 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 72 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 12 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 3 ANIMAL NUM: 348 DOSE: 150MG/KG48 HR DISP: Terminal Sacrifice HISTO: 0203183 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 73 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 13 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 1 ANIMAL NUM: 425 DOSE: 1500MG/K6 HR DISP: Terminal Sacrifice HISTO: 0203184 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 74 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 13 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 1 ANIMAL NUM: 426 DOSE: 1500MG/K6 HR DISP: Terminal Sacrifice HISTO: 0203185 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 75 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 13 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 1 ANIMAL NUM: 427 DOSE: 1500MG/K6 HR DISP: Terminal Sacrifice HISTO: 0203186 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney __________________________________________________________________________________________________________________________________ OBSERVATIONS Liver Lft Lobe - Centrilobular Necrosis Minimal Liver Med Lobe - Centrilobular Necrosis Minimal __________________________________________________________________________________________________________________________________ Page 76 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 13 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 1 ANIMAL NUM: 437 DOSE: 1500MG/K6 HR DISP: Terminal Sacrifice HISTO: 0203196 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 77 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 13 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 1 ANIMAL NUM: 438 DOSE: 1500MG/K6 HR DISP: Terminal Sacrifice HISTO: 0203197 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 78 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 13 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 1 ANIMAL NUM: 439 DOSE: 1500MG/K6 HR DISP: Terminal Sacrifice HISTO: 0203198 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe __________________________________________________________________________________________________________________________________ OBSERVATIONS Liver Med Lobe - Centrilobular Necrosis Minimal __________________________________________________________________________________________________________________________________ Page 79 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 14 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 428 DOSE: 1500MG/K18 HR DISP: Terminal Sacrifice HISTO: 0203187 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 80 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 14 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 429 DOSE: 1500MG/K18 HR DISP: Terminal Sacrifice HISTO: 0203188 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 81 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 14 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 430 DOSE: 1500MG/K18 HR DISP: Terminal Sacrifice HISTO: 0203189 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney __________________________________________________________________________________________________________________________________ OBSERVATIONS Liver Lft Lobe - Centrilobular Necrosis Moderate - Hepatocyte Degen Minimal - Sinusoid Congestion Moderate [ Necrosis TGLs = 1-1 ] Liver Med Lobe - Centrilobular Necrosis Moderate - Hepatocyte Degen Minimal - Sinusoid Congestion Moderate [ Necrosis TGLs = 1-2 ] __________________________________________________________________________________________________________________________________ Page 82 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 14 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 440 DOSE: 1500MG/K18 HR DISP: Terminal Sacrifice HISTO: 0203199 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney __________________________________________________________________________________________________________________________________ OBSERVATIONS Liver Lft Lobe - Centrilobular Necrosis Minimal Liver Med Lobe - Centrilobular Necrosis Mild - Sinusoid Congestion Mild [ Necrosis TGLs = 1-2 ] __________________________________________________________________________________________________________________________________ Page 83 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 14 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 441 DOSE: 1500MG/K18 HR DISP: Terminal Sacrifice HISTO: 0203200 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney __________________________________________________________________________________________________________________________________ OBSERVATIONS Liver Lft Lobe - Centrilobular Necrosis Mild - Sinusoid Congestion Mild [ Necrosis TGLs = 1-1 ] Liver Med Lobe - Centrilobular Necrosis Mild - Sinusoid Congestion Mild [ Necrosis TGLs = 1-2 ] __________________________________________________________________________________________________________________________________ Page 84 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 14 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 442 DOSE: 1500MG/K18 HR DISP: Terminal Sacrifice HISTO: 0203201 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney __________________________________________________________________________________________________________________________________ OBSERVATIONS Liver Lft Lobe - Centrilobular Necrosis Minimal Liver Med Lobe - Centrilobular Necrosis Minimal __________________________________________________________________________________________________________________________________ Page 85 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 15 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 431 DOSE: 1500MG/K24 HR DISP: Terminal Sacrifice HISTO: 0203190 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney __________________________________________________________________________________________________________________________________ OBSERVATIONS Liver Lft Lobe - Centrilobular Necrosis Mild - Sinusoid Congestion Mild Liver Med Lobe - Centrilobular Necrosis Moderate - Sinusoid Congestion Moderate __________________________________________________________________________________________________________________________________ Page 86 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 15 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 432 DOSE: 1500MG/K24 HR DISP: Terminal Sacrifice HISTO: 0203191 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney __________________________________________________________________________________________________________________________________ OBSERVATIONS Liver Lft Lobe - Centrilobular Necrosis Moderate - Sinusoid Congestion Moderate [ Necrosis TGLs = 1-1 ] Liver Med Lobe - Centrilobular Necrosis Moderate - Sinusoid Congestion Moderate [ Necrosis TGLs = 1-2 ] __________________________________________________________________________________________________________________________________ Page 87 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 15 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 433 DOSE: 1500MG/K24 HR DISP: Terminal Sacrifice HISTO: 0203192 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney __________________________________________________________________________________________________________________________________ OBSERVATIONS Liver Lft Lobe - Centrilobular Necrosis Moderate - Sinusoid Congestion Moderate Liver Med Lobe - Centrilobular Necrosis Moderate - Sinusoid Congestion Moderate __________________________________________________________________________________________________________________________________ Page 88 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 15 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 443 DOSE: 1500MG/K24 HR DISP: Terminal Sacrifice HISTO: 0203202 __________________________________________________________________________________________________________________________________ OBSERVATIONS Kidney - Renal Tubule Necrosis Mild Liver Lft Lobe - Centrilobular Necrosis Mild - Hepatocyte Hypertrophy Mild - Sinusoid Congestion Mild [ Necrosis TGLs = 2,3-1 ] Liver Med Lobe - Centrilobular Necrosis Mild - Hepatocyte Hypertrophy Mild - Sinusoid Congestion Mild [ Necrosis TGLs = 2,3-2 ] __________________________________________________________________________________________________________________________________ Page 89 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 15 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 444 DOSE: 1500MG/K24 HR DISP: Terminal Sacrifice HISTO: 0203203 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney __________________________________________________________________________________________________________________________________ OBSERVATIONS Liver Lft Lobe - Centrilobular Necrosis Moderate - Hepatocyte Hypertrophy Minimal - Sinusoid Congestion Moderate [ Necrosis TGLs = 1-1 ] Liver Med Lobe - Centrilobular Necrosis Moderate - Hepatocyte Hypertrophy Minimal - Sinusoid Congestion Moderate [ Necrosis TGLs = 1-2 ] __________________________________________________________________________________________________________________________________ Page 90 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 15 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 445 DOSE: 1500MG/K24 HR DISP: Terminal Sacrifice HISTO: 0203204 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney __________________________________________________________________________________________________________________________________ OBSERVATIONS Liver Lft Lobe - Centrilobular Necrosis Moderate - Hepatocyte Hypertrophy Minimal - Sinusoid Congestion Moderate [ Necrosis TGLs = 1,2-1 ] Liver Med Lobe - Centrilobular Necrosis Moderate - Hepatocyte Hypertrophy Minimal - Sinusoid Congestion Moderate [ Necrosis TGLs = 1,2-2 ] __________________________________________________________________________________________________________________________________ Page 91 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 16 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 3 ANIMAL NUM: 434 DOSE: 1500MG/K48 HR DISP: Terminal Sacrifice HISTO: 0203193 __________________________________________________________________________________________________________________________________ OBSERVATIONS Kidney - Renal Tubule Necrosis Minimal Liver Lft Lobe - Centrilobular Infiltrat Cell Mild, Mononuclear Cl - Centrilobular Necrosis Mild - Hepatocyte Degen Minimal - Hepatocyte Regeneration Mild - Sinusoid Congestion Minimal Liver Med Lobe - Centrilobular Infiltrat Cell Mild, Mononuclear Cl - Centrilobular Necrosis Mild - Hepatocyte Degen Minimal - Hepatocyte Regeneration Mild - Sinusoid Congestion Minimal __________________________________________________________________________________________________________________________________ Page 92 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 16 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 3 ANIMAL NUM: 435 DOSE: 1500MG/K48 HR DISP: Terminal Sacrifice HISTO: 0203194 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney __________________________________________________________________________________________________________________________________ OBSERVATIONS Liver Lft Lobe - Centrilobular Infiltrat Cell Mild, Mononuclear Cl - Centrilobular Necrosis Mild - Hepatocyte Regeneration Mild - Sinusoid Congestion Minimal [ Necrosis TGLs = 1,2-1 ] Liver Med Lobe - Centrilobular Infiltrat Cell Minimal, Mononuclear Cl - Centrilobular Necrosis Mild - Hepatocyte Regeneration Minimal - Sinusoid Congestion Minimal [ Necrosis TGLs = 1,2-2 ] __________________________________________________________________________________________________________________________________ Page 93 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 16 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 3 ANIMAL NUM: 436 DOSE: 1500MG/K48 HR DISP: Terminal Sacrifice HISTO: 0203195 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney __________________________________________________________________________________________________________________________________ OBSERVATIONS Liver Lft Lobe - Centrilobular Infiltrat Cell Minimal, Mononuclear Cl - Centrilobular Necrosis Mild Liver Med Lobe - Centrilobular Infiltrat Cell Minimal, Mononuclear Cl - Centrilobular Necrosis Mild __________________________________________________________________________________________________________________________________ Page 94 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 16 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 3 ANIMAL NUM: 446 DOSE: 1500MG/K48 HR DISP: Terminal Sacrifice HISTO: 0203205 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney __________________________________________________________________________________________________________________________________ OBSERVATIONS Liver Lft Lobe - Centrilobular Infiltrat Cell Mild, Mononuclear Cl - Centrilobular Necrosis Mild Liver Med Lobe - Centrilobular Infiltrat Cell Minimal, Mononuclear Cl - Centrilobular Necrosis Mild - Sinusoid Congestion Mild __________________________________________________________________________________________________________________________________ Page 95 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 16 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 3 ANIMAL NUM: 447 DOSE: 1500MG/K48 HR DISP: Terminal Sacrifice HISTO: 0203206 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney __________________________________________________________________________________________________________________________________ OBSERVATIONS Liver Lft Lobe - Centrilobular Infiltrat Cell Moderate, Mononuclear Cl - Centrilobular Necrosis Mild - Hepatocyte Regeneration Minimal Liver Med Lobe - Centrilobular Infiltrat Cell Minimal, Mononuclear Cl - Centrilobular Necrosis Mild - Sinusoid Congestion Mild [ Necrosis TGLs = 1-2 ] __________________________________________________________________________________________________________________________________ Page 96 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 16 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 3 ANIMAL NUM: 448 DOSE: 1500MG/K48 HR DISP: Terminal Sacrifice HISTO: 0203207 __________________________________________________________________________________________________________________________________ OBSERVATIONS Kidney - Renal Tubule Necrosis Minimal Liver Lft Lobe - Centrilobular Necrosis Moderate - Hepatocyte Degen Minimal - Hepatocyte Regeneration Moderate - Sinusoid Congestion Moderate [ Necrosis TGLs = 1-1 ] Liver Med Lobe - Centrilobular Necrosis Moderate - Hepatocyte Degen Minimal - Hepatocyte Regeneration Moderate - Sinusoid Congestion Mild [ Necrosis TGLs = 1-2 ] __________________________________________________________________________________________________________________________________ Page 97 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 17 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 1 ANIMAL NUM: 525 DOSE: 2000MG/K6 HR DISP: Terminal Sacrifice HISTO: 0203208 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 98 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 17 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 1 ANIMAL NUM: 526 DOSE: 2000MG/K6 HR DISP: Terminal Sacrifice HISTO: 0203209 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney __________________________________________________________________________________________________________________________________ OBSERVATIONS Liver Lft Lobe - Centrilobular Necrosis Minimal Liver Med Lobe - Centrilobular Necrosis Minimal __________________________________________________________________________________________________________________________________ Page 99 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 17 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 1 ANIMAL NUM: 527 DOSE: 2000MG/K6 HR DISP: Terminal Sacrifice HISTO: 0203210 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe __________________________________________________________________________________________________________________________________ OBSERVATIONS Liver Med Lobe - Centrilobular Necrosis Minimal __________________________________________________________________________________________________________________________________ Page 100 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 17 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 1 ANIMAL NUM: 537 DOSE: 2000MG/K6 HR DISP: Terminal Sacrifice HISTO: 0203220 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 101 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 17 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 1 ANIMAL NUM: 538 DOSE: 2000MG/K6 HR DISP: Terminal Sacrifice HISTO: 0203221 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Med Lobe __________________________________________________________________________________________________________________________________ OBSERVATIONS Liver Lft Lobe - Centrilobular Infiltrat Cell Minimal, Mononuclear Cl __________________________________________________________________________________________________________________________________ Page 102 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 17 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 1 ANIMAL NUM: 539 DOSE: 2000MG/K6 HR DISP: Terminal Sacrifice HISTO: 0203222 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney __________________________________________________________________________________________________________________________________ OBSERVATIONS Liver Lft Lobe - Centrilobular Necrosis Minimal Liver Med Lobe - Centrilobular Necrosis Minimal __________________________________________________________________________________________________________________________________ Page 103 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 18 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 528 DOSE: 2000MG/K18 HR DISP: Terminal Sacrifice HISTO: 0203211 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney __________________________________________________________________________________________________________________________________ OBSERVATIONS Liver Lft Lobe - Centrilobular Necrosis Mild - Hepatocyte Degen Minimal - Hepatocyte Hypertrophy Minimal - Sinusoid Congestion Mild [ Necrosis TGLs = 1-1 ] Liver Med Lobe - Centrilobular Necrosis Moderate - Hepatocyte Degen Minimal - Sinusoid Congestion Moderate [ Necrosis TGLs = 1-2 ] __________________________________________________________________________________________________________________________________ Page 104 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 18 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 529 DOSE: 2000MG/K18 HR DISP: Terminal Sacrifice HISTO: 0203212 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney __________________________________________________________________________________________________________________________________ OBSERVATIONS Liver Lft Lobe - Centrilobular Necrosis Minimal - Hepatocyte Degen Minimal - Sinusoid Congestion Mild [ Necrosis TGLs = 1-1 ] Liver Med Lobe - Centrilobular Necrosis Mild - Hepatocyte Degen Minimal - Sinusoid Congestion Moderate [ Necrosis TGLs = 1-2 ] __________________________________________________________________________________________________________________________________ Page 105 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 18 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 530 DOSE: 2000MG/K18 HR DISP: Terminal Sacrifice HISTO: 0203213 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney __________________________________________________________________________________________________________________________________ OBSERVATIONS Liver Lft Lobe - Centrilobular Necrosis Mild - Sinusoid Congestion Mild [ Necrosis TGLs = 1-1 ] Liver Med Lobe - Centrilobular Necrosis Minimal - Sinusoid Congestion Mild [ Necrosis TGLs = 1-2 ] __________________________________________________________________________________________________________________________________ Page 106 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 18 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 540 DOSE: 2000MG/K18 HR DISP: Terminal Sacrifice HISTO: 0203223 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney __________________________________________________________________________________________________________________________________ OBSERVATIONS Liver Lft Lobe - Centrilobular Necrosis Mild - Hepatocyte Hypertrophy Minimal - Sinusoid Congestion Moderate [ Necrosis TGLs = 1-1 ] Liver Med Lobe - Centrilobular Necrosis Moderate - Hepatocyte Hypertrophy Minimal - Sinusoid Congestion Moderate [ Necrosis TGLs = 1-2 ] __________________________________________________________________________________________________________________________________ Page 107 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 18 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 541 DOSE: 2000MG/K18 HR DISP: Terminal Sacrifice HISTO: 0203224 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 108 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 18 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 542 DOSE: 2000MG/K18 HR DISP: Terminal Sacrifice HISTO: 0203225 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney Liver Lft Lobe Liver Med Lobe __________________________________________________________________________________________________________________________________ Page 109 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 19 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 531 DOSE: 2000MG/K24 HR DISP: Terminal Sacrifice HISTO: 0203214 __________________________________________________________________________________________________________________________________ OBSERVATIONS Kidney - Renal Tubule Necrosis Mild Liver Lft Lobe - Centrilobular Necrosis Mild - Hepatocyte Hypertrophy Mild - Sinusoid Congestion Mild Liver Med Lobe - Centrilobular Infiltrat Cell Minimal, Mononuclear Cl - Centrilobular Necrosis Mild - Hepatocyte Hypertrophy Mild - Sinusoid Congestion Mild __________________________________________________________________________________________________________________________________ Page 110 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 19 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 532 DOSE: 2000MG/K24 HR DISP: Terminal Sacrifice HISTO: 0203215 __________________________________________________________________________________________________________________________________ OBSERVATIONS Kidney - Renal Tubule Necrosis Minimal Liver Lft Lobe - Centrilobular Necrosis Mild - Hepatocyte Hypertrophy Minimal - Sinusoid Congestion Minimal Liver Med Lobe - Centrilobular Necrosis Moderate - Hepatocyte Hypertrophy Minimal - Sinusoid Congestion Mild __________________________________________________________________________________________________________________________________ Page 111 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 19 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 533 DOSE: 2000MG/K24 HR DISP: Terminal Sacrifice HISTO: 0203216 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney __________________________________________________________________________________________________________________________________ OBSERVATIONS Liver Lft Lobe - Centrilobular Necrosis Mild - Hepatocyte Hypertrophy Minimal - Sinusoid Congestion Mild Liver Med Lobe - Centrilobular Necrosis Moderate - Hepatocyte Hypertrophy Minimal - Sinusoid Congestion Mild __________________________________________________________________________________________________________________________________ Page 112 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 19 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 543 DOSE: 2000MG/K24 HR DISP: Terminal Sacrifice HISTO: 0203226 __________________________________________________________________________________________________________________________________ OBSERVATIONS Kidney - Renal Tubule Necrosis Minimal Liver Lft Lobe - Centrilobular Necrosis Mild - Hepatocyte Hypertrophy Mild - Sinusoid Congestion Mild [ Necrosis TGLs = 1,2-1 ] Liver Med Lobe - Centrilobular Necrosis Moderate - Hepatocyte Hypertrophy Mild - Sinusoid Congestion Moderate [ Necrosis TGLs = 1,2-2 ] __________________________________________________________________________________________________________________________________ Page 113 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 19 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 544 DOSE: 2000MG/K24 HR DISP: Terminal Sacrifice HISTO: 0203227 __________________________________________________________________________________________________________________________________ OBSERVATIONS Kidney - Renal Tubule Necrosis Mild Liver Lft Lobe - Centrilobular Necrosis Moderate - Hepatocyte Hypertrophy Mild - Sinusoid Congestion Mild [ Necrosis TGLs = 1-1 ] Liver Med Lobe - Centrilobular Necrosis Moderate - Hepatocyte Hypertrophy Mild - Sinusoid Congestion Mild __________________________________________________________________________________________________________________________________ Page 114 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 19 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 2 ANIMAL NUM: 545 DOSE: 2000MG/K24 HR DISP: Terminal Sacrifice HISTO: 0203228 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Liver Med Lobe __________________________________________________________________________________________________________________________________ OBSERVATIONS Kidney - Renal Tubule Necrosis Mild Liver Lft Lobe - Centrilobular Infiltrat Cell Minimal, Mononuclear Cl - Centrilobular Necrosis Minimal __________________________________________________________________________________________________________________________________ Page 115 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 20 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 3 ANIMAL NUM: 534 DOSE: 2000MG/K48 HR DISP: Terminal Sacrifice HISTO: 0203217 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney __________________________________________________________________________________________________________________________________ OBSERVATIONS Liver Lft Lobe - Centrilobular Infiltrat Cell Minimal, Mononuclear Cl - Centrilobular Necrosis Mild Liver Med Lobe - Centrilobular Infiltrat Cell Minimal, Mononuclear Cl - Centrilobular Necrosis Mild __________________________________________________________________________________________________________________________________ Page 116 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 20 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 3 ANIMAL NUM: 535 DOSE: 2000MG/K48 HR DISP: Terminal Sacrifice HISTO: 0203218 __________________________________________________________________________________________________________________________________ OBSERVATIONS Kidney - Renal Tubule Necrosis Minimal Liver Lft Lobe - Centrilobular Infiltrat Cell Mild, Mononuclear Cl - Centrilobular Necrosis Mild - Hepatocyte Degen Mild - Hepatocyte Regeneration Mild [ Necrosis TGLs = 1,2-1 ] Liver Med Lobe - Centrilobular Infiltrat Cell Mild, Mononuclear Cl - Centrilobular Necrosis Mild - Hepatocyte Degen Mild - Hepatocyte Regeneration Mild - Sinusoid Congestion Minimal [ Necrosis TGLs = 1,2-2 ] __________________________________________________________________________________________________________________________________ Page 117 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 20 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 3 ANIMAL NUM: 536 DOSE: 2000MG/K48 HR DISP: Terminal Sacrifice HISTO: 0203219 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney __________________________________________________________________________________________________________________________________ OBSERVATIONS Liver Lft Lobe - Centrilobular Infiltrat Cell Minimal, Mononuclear Cl - Centrilobular Necrosis Moderate - Hepatocyte Degen Mild - Sinusoid Congestion Mild [ Necrosis TGLs = 1-1 ] Liver Med Lobe - Centrilobular Infiltrat Cell Minimal, Mononuclear Cl - Centrilobular Necrosis Mild - Hepatocyte Degen Mild __________________________________________________________________________________________________________________________________ Page 118 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 20 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 3 ANIMAL NUM: 546 DOSE: 2000MG/K48 HR DISP: Terminal Sacrifice HISTO: 0203229 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney __________________________________________________________________________________________________________________________________ OBSERVATIONS Liver Lft Lobe - Centrilobular Infiltrat Cell Minimal, Mononuclear Cl - Centrilobular Necrosis Moderate - Hepatocyte Degen Minimal - Hepatocyte Regeneration Mild - Sinusoid Congestion Moderate [ Necrosis TGLs = 1-1 ] Liver Med Lobe - Centrilobular Infiltrat Cell Minimal, Mononuclear Cl - Centrilobular Necrosis Mild - Hepatocyte Degen Minimal - Hepatocyte Regeneration Mild - Sinusoid Congestion Mild __________________________________________________________________________________________________________________________________ Page 119 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 20 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 3 ANIMAL NUM: 547 DOSE: 2000MG/K48 HR DISP: Terminal Sacrifice HISTO: 0203230 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Adren Cortex Kidney __________________________________________________________________________________________________________________________________ OBSERVATIONS Liver Lft Lobe - Centrilobular Infiltrat Cell Minimal, Mononuclear Cl - Centrilobular Necrosis Mild - Hepatocyte Regeneration Minimal - Sinusoid Congestion Mild Liver Med Lobe - Centrilobular Infiltrat Cell Minimal, Mononuclear Cl - Centrilobular Necrosis Moderate - Hepatocyte Regeneration Minimal - Sinusoid Congestion Mild __________________________________________________________________________________________________________________________________ Page 120 NTP Experiment-Test: 55801-07 INDIVIDUAL ANIMAL PATHOLOGY DATA Report: PEIRPT14 Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/24/04 Route: GAVAGE Time: 14:06:52 __________________________________________________________________________________________________________________________________ TMT: 20 SEX/SPECIES: Male FISCHER 344 RATS DAY ON DOSE: 3 ANIMAL NUM: 548 DOSE: 2000MG/K48 HR DISP: Terminal Sacrifice HISTO: 0203231 __________________________________________________________________________________________________________________________________ ORGAN AND ACCOUNTABLE SITE STATUS __________________________________________________________________________________________________________________________________ NORMAL Kidney __________________________________________________________________________________________________________________________________ OBSERVATIONS Liver Lft Lobe - Centrilobular Infiltrat Cell Mild, Mononuclear Cl - Centrilobular Necrosis Mild - Sinusoid Congestion Mild Liver Med Lobe - Centrilobular Infiltrat Cell Mild, Mononuclear Cl - Centrilobular Necrosis Moderate - Hepatocyte Regeneration Minimal - Sinusoid Congestion Mild __________________________________________________________________________________________________________________________________ Page 121 ----------------------------------- ---------- END-OF-REPORT ---------- -----------------------------------