Chemical Datasheet
EPINEPHRINE |
Chemical Identifiers
)
UN/NA Number - The United Nations-North America number (also called UN number or DOT number). 4-digit number identifying an individual chemical or group of chemicals with similar characteristics. Required on shipping papers; often shown on placards or labels. This numbering system was developed by the U.S. Department of Transportation, and then became the UN standard system for classifying hazardous materials.
CAS Number - Chemical Abstracts Service registry number. Unique identification number assigned to this chemical by the American Chemical Society.
CHRIS Code - 3-letter code used by the U.S. Coast Guard to identify individual chemicals included in its CHRIS (Chemical Hazards Response Information System) manual.
DOT Hazard Label - U.S. Department of Transportation hazard warning label for the chemical (such as flammable liquid or corrosive). This label must be displayed on shipped packages, railroad tank cars, and tank trucks according to specifications described in 49 CFR 172.
NFPA 704 - Text description of the diamond-shaped placard, which contains codes indicating the level of the chemical's health, flammability, and reactivity hazards, along with special hazards such as water- and air-reactivity. (The NFPA 704 diamond is also shown at the top of the datasheet.) See a guide to the NFPA diamond.
General Description - Brief description of the chemical's general appearance, behavior, and hazardousness.
List of data sources.
CAS Number - Chemical Abstracts Service registry number. Unique identification number assigned to this chemical by the American Chemical Society.
CHRIS Code - 3-letter code used by the U.S. Coast Guard to identify individual chemicals included in its CHRIS (Chemical Hazards Response Information System) manual.
DOT Hazard Label - U.S. Department of Transportation hazard warning label for the chemical (such as flammable liquid or corrosive). This label must be displayed on shipped packages, railroad tank cars, and tank trucks according to specifications described in 49 CFR 172.
NFPA 704 - Text description of the diamond-shaped placard, which contains codes indicating the level of the chemical's health, flammability, and reactivity hazards, along with special hazards such as water- and air-reactivity. (The NFPA 704 diamond is also shown at the top of the datasheet.) See a guide to the NFPA diamond.
General Description - Brief description of the chemical's general appearance, behavior, and hazardousness.
List of data sources.
| UN/NA Number | CAS Number | CHRIS Code | DOT Hazard Label |
|---|---|---|---|
|
none |
|
NFPA 704:
data unavailable
General Description
PHYSICAL DESCRIPTION: White to nearly-white microcrystalline powder or granules. Odorless. Melting point 211-212°C. Aqueous solutions are slightly alkaline. Slightly bitter, numbing taste.
Hazards
)
Reactivity Alerts - Special alerts if the chemical is especially reactive
(see list of reactivity alerts).
Air & Water Reactions - Special alerts if the chemical reacts with air, water, or moisture.
Fire Hazard - Description of the chemical's fire hazards (such as flammability, explosion risk, or byproducts that may evolve if the chemical is burned).
Health Hazard - Description of the chemical's health hazards (such as toxicity, flammability, or corrosivity).
Reactivity Profile - Description of the chemical's potential reactivity with other chemicals, air, and water. Also includes any other intrinsic reactive hazards (such as polymerizable or peroxidizable).
Reactive Groups - List of reactive groups that the chemical is assigned to, based on its known chemistry. Reactive groups are categories of chemicals that react in similar ways because their chemical structures are similar. Reactive groups are used to predict reactivity when you add a chemical to MyChemicals. Read more about reactive groups.
List of data sources.
Air & Water Reactions - Special alerts if the chemical reacts with air, water, or moisture.
Fire Hazard - Description of the chemical's fire hazards (such as flammability, explosion risk, or byproducts that may evolve if the chemical is burned).
Health Hazard - Description of the chemical's health hazards (such as toxicity, flammability, or corrosivity).
Reactivity Profile - Description of the chemical's potential reactivity with other chemicals, air, and water. Also includes any other intrinsic reactive hazards (such as polymerizable or peroxidizable).
Reactive Groups - List of reactive groups that the chemical is assigned to, based on its known chemistry. Reactive groups are categories of chemicals that react in similar ways because their chemical structures are similar. Reactive groups are used to predict reactivity when you add a chemical to MyChemicals. Read more about reactive groups.
List of data sources.
Reactivity Alerts
none
Air & Water Reactions
This chemical darkens slowly on exposure to air and light. Water insoluble. Readily soluble in aqueous solutions of inorganic acids. Solutions undergo oxidation in the presence of oxygen.
Fire Hazard
Flash point data for this chemical are not available. It is probably combustible. (NTP, 1992)
Health Hazard
SYMPTOMS: Symptoms of exposure to this compound may include restlessness, anxiety, fear, throbbing headache, tremor, weakness, dizziness, palpitations, cerebral hemorrhage and cardiac arrhythmias. Other symptoms may include pallor, tenseness and respiratory difficulty. The blood pressure is markedly raised initially but may be below normal later, and may be accompanied by persistent anuria. Exposure may also result in ventricular fibrillation, dyspnea, hyperglycemia, tachycardia, coldness of the extremities and pulmonary edema. Exposure may also result in convulsions, nausea and vomiting, chills, cyanosis, irritability, fever, nervousness, suicidal behavior, mania, blurred vision, opisthotonus, spasms, gasping respiration, coma, respiratory failure and, rarely, death. Contact with this compound may cause irritation. It may also cause contact dermatitis. Inhalation may cause bronchial irritation, sleeplessness and rapid heartbeat. It may also cause epigastric pain. Inhalation or injection of the decomposed chemical will cause a psychosis-like state with hallucinations and morbid fears. Prolonged nasal use leads to chronic nasal congestion. Facial flushing has been reported. Other symptoms of exposure include faintness, trembling, perspiration and extrasystoles. Eye effects include epithelial disturbances such as allergy or contact sensitivity characterized by itching and burning sensation, epiphora and hyperemia of the conjunctiva and lids; reactive hyperemia, tiny black or dark-brown deposits in the conjunctiva, "black cornea", epithelial edema and, rarely, follicular conjunctivitis, white keratinized plaque in the conjunctiva, ocular pemphigoid, loss of eyelashes, excessive tearing and persistent meibomianitis. Other eye effects include corneal endothelial disturbances such as dilated pupils and corneal edema; retinopathy and choroidopathy; lens changes and intraocular pressure. Eye inflammation also occurs.
ACUTE/CHRONIC HAZARDS: This compound is highly toxic by ingestion. It may be fatal by inhalation or skin absorption. It may cause irritation. When heated to decomposition it emits toxic fumes of carbon monoxide, carbon dioxide and nitrogen oxides. (NTP, 1992)
ACUTE/CHRONIC HAZARDS: This compound is highly toxic by ingestion. It may be fatal by inhalation or skin absorption. It may cause irritation. When heated to decomposition it emits toxic fumes of carbon monoxide, carbon dioxide and nitrogen oxides. (NTP, 1992)
Reactivity Profile
EPINEPHRINE is incompatible with oxidizers, alkalis, copper, iron, silver, zinc and other metals; gum and tannin. It is also incompatible with acids, acid chlorides and acid anhydrides. It reacts with salts of sulfurous acid (NTP, 1992).
Belongs to the Following Reactive Group(s)
Response Recommendations
)
Firefighting - Response recommendations if the chemical is on fire (or near a fire).
Non-Fire Response - Response recommendations if the chemical isn't on fire (or near a fire).
Protective Clothing - Recommendations for protective gear and, in some cases, a table of breakthrough times for protective materials.
First Aid - Recommended first aid treatment for people exposed to the chemical.
List of data sources.
Non-Fire Response - Response recommendations if the chemical isn't on fire (or near a fire).
Protective Clothing - Recommendations for protective gear and, in some cases, a table of breakthrough times for protective materials.
First Aid - Recommended first aid treatment for people exposed to the chemical.
List of data sources.
Firefighting
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used. (NTP, 1992)
Non-Fire Response
SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with 5% acetic acid, then transfer the dampened material to a suitable container. Use absorbent paper dampened with 5% acetic acid to pick up any remaining material. Your contaminated clothing and the absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with 5% acetic acid followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
STORAGE PRECAUTIONS: You should protect this chemical from exposure to light. Keep the container tightly closed under an inert atmosphere, and store under ambient temperatures. (NTP, 1992)
STORAGE PRECAUTIONS: You should protect this chemical from exposure to light. Keep the container tightly closed under an inert atmosphere, and store under ambient temperatures. (NTP, 1992)
Protective Clothing
RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter). (NTP, 1992)
First Aid
EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.
INGESTION: If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Generally, the induction of vomiting is NOT recommended outside of a physician's care due to the risk of aspirating the chemical into the victim's lungs. However, if the victim is conscious and not convulsing and if medical help is not readily available, consider the risk of inducing vomiting because of the high toxicity of the chemical ingested. Ipecac syrup or salt water may be used in such an emergency. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)
SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.
INGESTION: If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Generally, the induction of vomiting is NOT recommended outside of a physician's care due to the risk of aspirating the chemical into the victim's lungs. However, if the victim is conscious and not convulsing and if medical help is not readily available, consider the risk of inducing vomiting because of the high toxicity of the chemical ingested. Ipecac syrup or salt water may be used in such an emergency. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)
Physical Properties
)
This section contains physical properties, flammability limits, and toxic thresholds for this chemical (see
definitions of each property).
More property data is available for common chemicals.
Guide to toxic levels of concern (AEGLs, ERPGs, TEELs, and IDLH).
List of data sources.
Guide to toxic levels of concern (AEGLs, ERPGs, TEELs, and IDLH).
List of data sources.
| Molecular Formula: |
|
Flash Point: data unavailable
Lower Explosive Limit: data unavailable
Upper Explosive Limit: data unavailable
Autoignition Temperature: data unavailable
Melting Point:
412-414 ° F
(NTP, 1992)
Vapor Pressure: data unavailable
Vapor Density: data unavailable
Specific Gravity: data unavailable
Boiling Point: data unavailable
Molecular Weight:
183.21
(NTP, 1992)
Water Solubility:
<0.1 mg/mL
at 64° F
(NTP, 1992)
AEGL:
data unavailable
ERPG:
data unavailable
| TEEL-1 | TEEL-2 | TEEL-3 |
|---|---|---|
| 0.25 mg/m3 | 0.25 mg/m3 | 0.25 mg/m3 |
| (SCAPA, 2008) | ||
IDLH: data unavailable
Regulatory Information
)
Regulatory Names - Names under which this chemical is regulated under several U.S. federal laws: CAA (Clean Air Act of 1990), CERCLA (Comprehensive Environmental Response, Compensation, and Liability Act of 1980, also known as Superfund), EPCRA (Emergency Planning and Community Right-to-Know Act, also known as SARA Title III), and RCRA (Resource Conservation and Recovery Act of 1976).
CAA RMP - Indicates whether this chemical is regulated under Section 112(r) of the Clean Air Act, which lists about 100 toxic, flammable, or explosive hazardous substances. (Section 112(r) mandates the Risk Management Plan regulations.) For listed chemicals, the Threshold Quantity (from 40 CFR 68) is also shown. Facilities that use more than the threshold quantity of a listed chemical in a process are subject to the CAA accidental release prevention provisions.
CERCLA - Indicates whether this chemical is listed as a hazardous substance under CERCLA. For listed chemicals, the Reportable Quantity (from 40 CFR 302) is also shown. Facilities that spill more than the reportable quantity of a listed chemical must report it to federal, state, and local governments.
EHS (EPCRA 302) - Indicates whether this chemical is listed as an Extremely Hazardous Substance under Section 302 of EPCRA. For listed chemicals, the Threshold Planning Quantity (from 40 CFR 355) is also shown. Facilities that store more than the threshold quantity of an EHS chemical must meet the reporting, community right-to-know, and emergency planning requirements of EPCRA.
TRI (EPCRA 313) - Indicates whether this chemical is listed as a toxic chemical under Section 313 (Toxics Release Inventory) of EPCRA. Facilities that manufacture, store, or use significant amounts of Section 313 chemicals may be required to submit annual reports about any releases into the environment (see 40 CFR 372).
RCRA Chemical Code - 4-character identification code assigned to this substance under RCRA.
CAA RMP - Indicates whether this chemical is regulated under Section 112(r) of the Clean Air Act, which lists about 100 toxic, flammable, or explosive hazardous substances. (Section 112(r) mandates the Risk Management Plan regulations.) For listed chemicals, the Threshold Quantity (from 40 CFR 68) is also shown. Facilities that use more than the threshold quantity of a listed chemical in a process are subject to the CAA accidental release prevention provisions.
CERCLA - Indicates whether this chemical is listed as a hazardous substance under CERCLA. For listed chemicals, the Reportable Quantity (from 40 CFR 302) is also shown. Facilities that spill more than the reportable quantity of a listed chemical must report it to federal, state, and local governments.
EHS (EPCRA 302) - Indicates whether this chemical is listed as an Extremely Hazardous Substance under Section 302 of EPCRA. For listed chemicals, the Threshold Planning Quantity (from 40 CFR 355) is also shown. Facilities that store more than the threshold quantity of an EHS chemical must meet the reporting, community right-to-know, and emergency planning requirements of EPCRA.
TRI (EPCRA 313) - Indicates whether this chemical is listed as a toxic chemical under Section 313 (Toxics Release Inventory) of EPCRA. Facilities that manufacture, store, or use significant amounts of Section 313 chemicals may be required to submit annual reports about any releases into the environment (see 40 CFR 372).
RCRA Chemical Code - 4-character identification code assigned to this substance under RCRA.
| Regulatory Names: |
|
CAA RMP:
Not a regulated chemical.
CERCLA:
Regulated chemical with a Reportable Quantity of 1000 pounds.
EHS (EPCRA 302):
Not a regulated chemical.
TRI (EPCRA 313):
Not a regulated chemical.
RCRA Chemical Code:
P042
Alternate Chemical Names
)
This section provides a listing of alternate names for this chemical, including trade names, synonyms, and foreign names.
- (-)-(R)-EPINEPHRINE
- (-)-3,4-DIHYDROXY-ALPHA-((METHYLAMINO)METHYL)BENZYL ALCOHOL
- (-)-ADRENALINE
- (-)-EPINEPHRINE
- (R)-4-(1-HYDROXY-2-(METHYLAMINO)ETHYL)-1,2-BENZENEDIOL
- (R)-ADRENALINE
- (R)-EPINEPHRINE
- 1,2-BENZENEDIOL, 4-[1-HYDROXY-2-(METHYLAMINO)ETHYL]-, (R)-
- 1-(3,4-DIHYDROXYPHENYL)-2-(METHYLAMINO)ETHANOL
- 3,4-DIHYDROXY-1-[1-HYDROXY-2-(METHYLAMINO)ETHYL]BENZENE
- 3,4-DIHYDROXY-ALPHA-((METHYLAMINO)METHYL)BENZYL ALCOHOL
- 3,4-DIHYDROXY-ALPHA-[(METHYLAMINO)METHYL]BENZYL ALCOHOL
- 4-[1-HYDROXY-2-(METHYLAMINO)ETHYL]-1,2-BENZENEDIOL
- ADNEPHRINE
- ADRENAL
- ADRENALIN
- ADRENALIN IN OIL
- ADRENALIN-MEDIHALER
- ADRENALINE
- ADRENAMINE
- ADRENAN
- ADRENAPAX
- ADRENASOL
- ADRENATRATE
- ADRENINE
- ADRENODIS
- ADRENOHORMA
- ADRENOSAN
- ADRENUTOL
- ADRIN
- ADRINE
- ANTIASTHMATIQUE
- ASMATANE MIST
- ASTHMA METER MIST
- ASTHMA-NEFRIN
- ASTHMAHALIN
- ASTMINHAL
- BALMADREN
- BENZYL ALCOHOL, 3,4-DIHYDROXY-ALPHA-[(METHYLAMINO)METHYL]-, (-)-
- BERNARENIN
- BIORENINE
- BOSMIN
- BREVIRENIN
- BRONKAID MIST
- CHELAFRIN
- CORISOL
- DRENAMIST
- DYLEPHRIN
- DYSPNE-INHAL
- EPIFRIN
- EPINEFRINA
- EPINEPHRAN
- EPIRENAMINE
- EPIRENAN
- EPIRENIN
- EPITRATE
- ESPHYGMOGENINA
- EXADRIN
- GLAUCOSAN
- GLYCIRENAN
- HAEMOSTASIN
- HAEMOSTATIN
- HEKTALIN
- HEMISINE
- HEMOSTASIN
- HEMOSTATIN
- HYPERNEPHRIN
- HYPORENIN
- INTRANEFRIN
- ISOPTOEPINAL
- KIDOLINE
- L-1-(3,4-DIHYDROXYPHENYL)-2-METHYLAMINOETHANOL
- L-ADRENALIN
- L-ADRENALINE
- L-EPINEPHRINE
- L-EPINEPHRINE (SYNTHETIC)
- L-EPIRENAMINE
- L-METHYLAMINOETHANOLCATECHOL
- LEVOEPINEPHRINE
- LEVORENIN
- LEVORENINE
- LEVORENINUM
- LYODRIN
- LYOPHRIN
- MEDIHALER-EPI
- METANEPHRIN
- METHYLAMINOETHANOLCATECHOL
- METHYLARTERENOL
- MUCIDRINA
- MYOSTHENINE
- MYTRATE
- NEPHRIDINE
- NIERALINE
- PARANEPHRIN
- PRIMATENE MIST
- R-(-)-EPINEPHRINE
- RCRA WASTE NUMBER P042
- RENAGLADIN
- RENAGLANDIN
- RENAGLANDULIN
- RENALEPTINE
- RENALINA
- RENOFORM
- RENOSTYPRICIN
- RENOSTYPTICIN
- RENOSTYPTIN
- SCURENALINE
- SINDRENINA
- SOLADREN
- SPHYGMOGENIN
- STRYPTIRENAL
- STYPTIRENAL
- SUPRACAPSULIN
- SUPRADIN
- SUPRANEFRAN
- SUPRANEPHRANE
- SUPRANEPHRINE
- SUPRANOL
- SUPRARENALINE
- SUPRARENIN
- SUPREL
- SURENINE
- SURRENINE
- SUS-PHRINE
- SUSPHRINE
- SYMPATHIN I
- TAKAMINA
- TAKAMINE
- TOKAMINA
- TONOGEN
- VAPONEFRIN
- VASOCONSTRICTINE
- VASOCONSTRICTOR
- VASODRINE
- VASOTON
- VASOTONIN
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