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Title Single photon emission computed tomography with thallium-201 during adenosine-induced coronary hyperemia: Correlation with coronary arteriography, exercise thallium imaging and two-dimensional echocardiography
Creator/Author Nguyen, T. ; Heo, J. ; Ogilby, J.D. ; Iskandrian, A.S. (Philadelphia Heart Institute, PA (USA))
Publication Date1990 Nov 01
OSTI IdentifierOSTI ID: 6070092
Other Number(s)ISSN0735-1097; CODEN: JACCD
Resource TypeJournal Article
Resource RelationJournal of the American College of Cardiology ; Vol/Issue: 16:6
Subject550601 -- Medicine-- Unsealed Radionuclides in Diagnostics ;550602 -- Medicine-- External Radiation in Diagnostics-- (1980-); CARDIOVASCULAR DISEASES-- DIAGNOSIS;SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY-- ACCURACY; ADENOSINE;BIOMEDICAL RADIOGRAPHY;COMPARATIVE EVALUATIONS;EXERCISE;FEASIBILITY STUDIES;PATIENTS;THALLIUM 201;ULTRASONOGRAPHY
Related SubjectBETA DECAY RADIOISOTOPES;COMPUTERIZED TOMOGRAPHY;DAYS LIVING RADIOISOTOPES;DIAGNOSTIC TECHNIQUES;DISEASES;ELECTRON CAPTURE RADIOISOTOPES;EMISSION COMPUTED TOMOGRAPHY;HEAVY NUCLEI;ISOMERIC TRANSITION ISOTOPES;ISOTOPES;MEDICINE;NUCLEAR MEDICINE;NUCLEI;NUCLEOSIDES;NUCLEOTIDES;ODD-EVEN NUCLEI;ORGANIC COMPOUNDS;RADIOISOTOPES;RADIOLOGY;RIBOSIDES;SECONDS LIVING RADIOISOTOPES;THALLIUM ISOTOPES;TOMOGRAPHY
Description/Abstract The feasibility, safety and diagnostic accuracy of single photon emission computed tomography (SPECT) with thallium-201 imaging during adenosine-induced coronary hyperemia were evaluated in 53 patients with and 7 without coronary artery disease proved by coronary angiography.^Adenosine was infused intravenously at a dose of 0.14 mg/kg body weight per min for 6 min and thallium was injected at 3 min.^Adenosine caused an increase in heart rate (68 +/- 12 at baseline versus 87 +/- 18 beats/min at peak effect, p less than 0.0001) but no change in blood pressure.^The sensitivity and specificity were 92% (95% confidence intervals 81% to 98%) and 100% (95% confidence intervals 59% to 100%), respectively; 20 (61%) of 33 patients with multivessel coronary artery disease were also correctly identified.^In 30 patients, the predictive accuracy of adenosine thallium imaging was slightly higher than that of exercise SPECT thallium imaging (90% versus 80%, p = NS) (95% confidence intervals 72% to 97% and 61% to 92%, respectively).^In 25 patients, two-dimensional echocardiography during adenosine infusion disclosed a new wall motion abnormality in 2 (10%) of 20 patients with coronary artery disease; 80% of these patients had reversible thallium defects (p less than 0.001).^Side effects were mild and transient; aminophylline was used in only three patients.^Thus, adenosine SPECT thallium imaging provides a high degree of accuracy in the diagnosis of coronary artery disease.^The results are comparable with those of exercise SPECT thallium imaging.^Most reversible defects in the adenosine study are not associated with any transient wall motion abnormality.
Country of PublicationUnited States
LanguageEnglish
FormatPages: 1375-1383
System Entry Date2001 May 13

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