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Title Postprandial hemodynamics in the conscious rat
Creator/Author Anzueto Hernandez, L. ; Kvietys, P.R. ; Granger, D.N.
Publication Date1986 Jul 01
OSTI IdentifierOSTI ID: 5017360
Other Number(s)CODEN: AJPHA
Resource TypeJournal Article
Resource RelationAm. J. Physiol.
Subject551001 -- Physiological Systems-- Tracer Techniques; DIGESTION-- PHYSIOLOGY;INTESTINES-- BLOOD FLOW; ATROPINE;FOOD;MICROSPHERES;RATS;STOMACH;TRACER TECHNIQUES
Related SubjectALKALOIDS;ANIMALS;AUTONOMIC NERVOUS SYSTEM AGENTS;BODY;DIGESTIVE SYSTEM;DRUGS;GASTROINTESTINAL TRACT;ISOTOPE APPLICATIONS;MAMMALS;ORGANIC COMPOUNDS;ORGANS;PARASYMPATHOLYTICS;RODENTS;VERTEBRATES
Description/Abstract The postprandial intestinal hyperemia was studied in conscious and anesthetized rats using the radioactive microsphere technique.^Carbohydrate, protein, lipid, and mixed meals, and the vehicle (Tyrode`s solution), were placed in the stomach via a gastrostomy tube.^In conscious rats, blood flow increased by 40-80% in the duodenum and jejunum 1 h after either a carbohydrate, lipid, protein, or mixed meal.^Tyrode`s solution produced a comparable hyperemia.^Blood flow in the distal bowel segments (ileum, cecum, and colon) was significantly increased only by Tyrode`s solution and the carbohydrate meal.^The proximal intestinal hyperemia produced by the mixed meal in conscious animals was significantly attenuated by vagotomy yet unaltered by atropine pretreatment.^In contrast to the results obtained from conscious rats, the mixed meal did not significantly alter intestinal blood flow in anesthetized animals.^The results of this study indicate that the postprandial intestinal hyperemia is much greater in conscious than anesthetized animals.^This difference may result from the higher resting blood flows in the latter group.^The hyperemic response in conscious animals may be mediated by the vagus nerve.
Country of PublicationUnited States
LanguageEnglish
FormatPages: G117-G123
System Entry Date2001 May 13

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