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Title NEUTRON-CAPTURE THERAPY IN A CASE OF CEREBELLAR SARCOMA TREATED INITIALLY WITH X- RADIATION. A CLINICAL AND HISTOLOGICAL STUDY
Creator/Author Farr, L.E. ; Haymaker, W. ; Calvo, W. ; Yamamoto, Y.L. ; Lippincott, S.W.
Publication Date1961 Jan 01
OSTI IdentifierOSTI ID: 4841070
Other Number(s)CODEN: ANPTA; 0001-6322
Resource TypeJournal Article
Resource RelationActa Neuropathologica (Germany); Vol: 1
Research OrgBrookhaven National Lab., Upton, N.Y.;and Armed Forces Inst. of Pathology, Washington, D.C.
SubjectBIOLOGY AND MEDICINE; MAN; NERVOUS SYSTEM; NEUTRONS; NITROGEN COMPOUNDS; RADIATION DOSES; RADIOTHERAPY; TUMORS; X RADIATION
Description/Abstract The case of a girl who was born with a large retroauricular mass diagnosed clinically as hemangioma is presented. It responded well to x-ray therapy. When she was 11 years old, a sarcoma was removed from the cerebellum. No evidence could be found that the sarcoma had originated from the retroauricular tumor. After the use of nitrogen mustard locally and three courses of x-ray therapy to the tumor over a period of 91/2 months with a total radiation dose of approximately 7953 r the patient was growing moribund. During 4 neutron-capture treatments, which were directed chiefly toward the suboccipital region, striking improvement occurred-to such an extent that the patient was able for a time to sit up in a wheelchair and converse. As a result of the therapy, all tumor which had spread suboccipitally and into the neck vanished, as did also virtually all tumor in the dorsal third of the cerebellum, the region receiving the largest concentration of thermal neutrons. In the middle third of the cerebellum large and small tumor aggregates, some of them calcified, were necrotic and were walled off by hyperplastic connective tissue. In the ventral third of the cerebellum, in a region presumably out of the range of an effective concentration of thermal neutrons, the tumor grew unimpeded. Evidence indicated that the sarcoma in this case originated in the vascular sheath, chiefly about vessels in the granular layer of the cerebellum. Life was prolonged approximately 8 months by the neutron-capture therapy. (auth)
LanguageEnglish
FormatPages: 34-55
System Entry Date2001 Jun 03

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