NTP EXP/TEST: 95003-03 METHYL TRANS-STYRYL KETONE PAGE: 1 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 06/22/05 ROUTE: SKIN APPLICATION TIME: 08:57:27 EIS REPORT 37 FACILITY: BIORELIANCE NTP C#: C95003 CONTRACT NUMBER: N01-ES-75408 CAS NUMBER: 1896-62-4 ANIMAL SUPPLIER: TACONIC FARMS CAGE RANGE: ALL DATE RANGE: ALL REASONS FOR REMOVAL: ALL REMOVAL DATE RANGE: ALL TREATMENT GROUPS: INCLUDE ALL NTP EXP/TEST: 95003-03 METHYL TRANS-STYRYL KETONE PAGE: 2 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 06/22/05 ROUTE: SKIN APPLICATION EISRPT37 TIME: 08:57:27 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 7 ROOM/AREA: 39 FIRST DOSE: 12/11/01 SEX: FEMALE TRT: VEHICLE CONTROL PROCEDURE SET: 2 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP. NTP EXP/TEST: 95003-03 METHYL TRANS-STYRYL KETONE PAGE: 3 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 06/22/05 ROUTE: SKIN APPLICATION EISRPT37 TIME: 08:57:27 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 19 ROOM/AREA: 39 FIRST DOSE: 12/11/01 SEX: FEMALE TRT: CONTROL SPECIAL PROCEDURE SET: 4 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP. NTP EXP/TEST: 95003-03 METHYL TRANS-STYRYL KETONE PAGE: 4 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 06/22/05 ROUTE: SKIN APPLICATION EISRPT37 TIME: 08:57:27 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 8 ROOM/AREA: 39 FIRST DOSE: 12/11/01 SEX: FEMALE TRT: 22.0 MG/KG PROCEDURE SET: 2 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP. NTP EXP/TEST: 95003-03 METHYL TRANS-STYRYL KETONE PAGE: 5 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 06/22/05 ROUTE: SKIN APPLICATION EISRPT37 TIME: 08:57:27 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 20 ROOM/AREA: 39 FIRST DOSE: 12/11/01 SEX: FEMALE TRT: 22.0 MG/KG PROCEDURE SET: 4 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP. NTP EXP/TEST: 95003-03 METHYL TRANS-STYRYL KETONE PAGE: 6 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 06/22/05 ROUTE: SKIN APPLICATION EISRPT37 TIME: 08:57:27 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 9 ROOM/AREA: 39 FIRST DOSE: 12/11/01 SEX: FEMALE TRT: 44.0 MG/KG PROCEDURE SET: 2 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP. NTP EXP/TEST: 95003-03 METHYL TRANS-STYRYL KETONE PAGE: 7 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 06/22/05 ROUTE: SKIN APPLICATION EISRPT37 TIME: 08:57:27 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 21 ROOM/AREA: 39 FIRST DOSE: 12/11/01 SEX: FEMALE TRT: 44.0 MG/KG PROCEDURE SET: 4 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP. NTP EXP/TEST: 95003-03 METHYL TRANS-STYRYL KETONE PAGE: 8 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 06/22/05 ROUTE: SKIN APPLICATION EISRPT37 TIME: 08:57:27 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 10 ROOM/AREA: 39 FIRST DOSE: 12/11/01 SEX: FEMALE TRT: 87.5 MG/KG PROCEDURE SET: 2 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 91 91 93 03/13/02 93 03/13/02 1/14 Thickened Site Of Application REMOVED ** CID 91 ** REASON - TSAC 93 03/13/02 Thickened Site Of Application 93 93 93 03/13/02 93 03/13/02 1/14 Irritation Site Of Application REMOVED ** CID 93 ** REASON - TSAC 93 03/13/02 Irritation Site Of Application 99 99 93 03/13/02 93 03/13/02 1/14 Irritation Site Of Application REMOVED ** CID 99 ** REASON - TSAC 93 03/13/02 Irritation Site Of Application NTP EXP/TEST: 95003-03 METHYL TRANS-STYRYL KETONE PAGE: 9 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 06/22/05 ROUTE: SKIN APPLICATION EISRPT37 TIME: 08:57:27 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 22 ROOM/AREA: 39 FIRST DOSE: 12/11/01 SEX: FEMALE TRT: 87.5 MG/KG PROCEDURE SET: 4 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP. NTP EXP/TEST: 95003-03 METHYL TRANS-STYRYL KETONE PAGE: 10 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 06/22/05 ROUTE: SKIN APPLICATION EISRPT37 TIME: 08:57:27 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 11 ROOM/AREA: 39 FIRST DOSE: 12/11/01 SEX: FEMALE TRT: 175 MG/KG PROCEDURE SET: 2 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 101 101 93 03/13/02 93 03/13/02 1/14 Irritation Site Of Application REMOVED ** CID 101 ** REASON - TSAC 93 03/13/02 Irritation Site Of Application 102 102 85 03/05/02 85 03/05/02 1/14 Ulcer Site Of Application 85 03/05/02 85 03/05/02 1/14 Thickened Site Of Application 78 02/26/02 93 03/13/02 2/14 Irritation Site Of Application REMOVED ** CID 102 ** REASON - TSAC 93 03/13/02 Irritation Site Of Application 103 103 78 02/26/02 93 03/13/02 3/14 Irritation Site Of Application 85 03/05/02 93 03/13/02 2/14 Thickened Site Of Application REMOVED ** CID 103 ** REASON - TSAC 93 03/13/02 Thickened Site Of Application 93 03/13/02 Irritation Site Of Application 104 104 36 01/15/02 36 01/15/02 1/14 Irritation Site Of Application 85 03/05/02 93 03/13/02 2/14 Thickened Site Of Application REMOVED ** CID 104 ** REASON - TSAC 93 03/13/02 Thickened Site Of Application 105 105 44 01/23/02 78 02/26/02 2/14 Irritation Site Of Application 85 03/05/02 93 03/13/02 2/14 Thickened Site Of Application 93 03/13/02 93 03/13/02 1/14 Ulcer Site Of Application REMOVED ** CID 105 ** REASON - TSAC 93 03/13/02 Ulcer Site Of Application 93 03/13/02 Thickened Site Of Application 106 106 85 03/05/02 93 03/13/02 2/14 Thickened Site Of Application 78 02/26/02 93 03/13/02 2/14 Irritation Site Of Application REMOVED ** CID 106 ** REASON - TSAC 93 03/13/02 Thickened Site Of Application 93 03/13/02 Irritation Site Of Application 107 107 72 02/20/02 78 02/26/02 2/14 Ulcer Site Of Application 78 02/26/02 78 02/26/02 1/14 Irritation Site Of Application NTP EXP/TEST: 95003-03 METHYL TRANS-STYRYL KETONE PAGE: 11 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 06/22/05 ROUTE: SKIN APPLICATION EISRPT37 TIME: 08:57:27 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 11 ROOM/AREA: 39 FIRST DOSE: 12/11/01 SEX: FEMALE TRT: 175 MG/KG PROCEDURE SET: 2 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS ANIMAL DATA - 107 107 85 03/05/02 85 03/05/02 1/14 Thickened Site Of Application REMOVED ** CID 107 ** REASON - TSAC 93 03/13/02 Unremarkable 108 108 93 03/13/02 93 03/13/02 1/14 Ulcer Site Of Application 44 01/23/02 78 02/26/02 2/14 Irritation Site Of Application 85 03/05/02 93 03/13/02 2/14 Thickened Site Of Application REMOVED ** CID 108 ** REASON - TSAC 93 03/13/02 Ulcer Site Of Application 93 03/13/02 Thickened Site Of Application 109 109 93 03/13/02 93 03/13/02 1/14 Thickened Site Of Application 85 03/05/02 85 03/05/02 1/14 Irritation Site Of Application 72 02/20/02 78 02/26/02 2/14 Ulcer Site Of Application REMOVED ** CID 109 ** REASON - TSAC 93 03/13/02 Thickened Site Of Application 110 110 44 01/23/02 44 01/23/02 1/14 Irritation Site Of Application REMOVED ** CID 110 ** REASON - TSAC 93 03/13/02 Unremarkable NTP EXP/TEST: 95003-03 METHYL TRANS-STYRYL KETONE PAGE: 12 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 06/22/05 ROUTE: SKIN APPLICATION EISRPT37 TIME: 08:57:27 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 23 ROOM/AREA: 39 FIRST DOSE: 12/11/01 SEX: FEMALE TRT: 175 MG/KG PROCEDURE SET: 4 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP. NTP EXP/TEST: 95003-03 METHYL TRANS-STYRYL KETONE PAGE: 13 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 06/22/05 ROUTE: SKIN APPLICATION EISRPT37 TIME: 08:57:27 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 12 ROOM/AREA: 39 FIRST DOSE: 12/11/01 SEX: FEMALE TRT: 350 MG/KG PROCEDURE SET: 2 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 111 111 78 02/26/02 78 02/26/02 1/14 Ulcer Site Of Application 8 12/18/01 85 03/05/02 2/14 Thickened Site Of Application 29 01/08/02 93 03/13/02 10/14 Irritation Site Of Application REMOVED ** CID 111 ** REASON - TSAC 93 03/13/02 Irritation Site Of Application 112 112 8 12/18/01 93 03/13/02 3/14 Thickened Site Of Application 29 01/08/02 93 03/13/02 10/14 Irritation Site Of Application REMOVED ** CID 112 ** REASON - TSAC 93 03/13/02 Thickened Site Of Application 93 03/13/02 Irritation Site Of Application 113 113 29 01/08/02 93 03/13/02 8/14 Irritation Site Of Application 72 02/20/02 78 02/26/02 2/14 Ulcer Site Of Application 8 12/18/01 93 03/13/02 3/14 Thickened Site Of Application REMOVED ** CID 113 ** REASON - TSAC 93 03/13/02 Thickened Site Of Application 93 03/13/02 Irritation Site Of Application 114 114 8 12/18/01 16 12/26/01 2/14 Thickened Site Of Application 23 01/02/02 93 03/13/02 10/14 Irritation Site Of Application REMOVED ** CID 114 ** REASON - TSAC 93 03/13/02 Irritation Site Of Application 115 115 8 12/18/01 93 03/13/02 4/14 Thickened Site Of Application 29 01/08/02 93 03/13/02 10/14 Irritation Site Of Application REMOVED ** CID 115 ** REASON - TSAC 93 03/13/02 Thickened Site Of Application 93 03/13/02 Irritation Site Of Application 116 116 8 12/18/01 85 03/05/02 3/14 Thickened Site Of Application 72 02/20/02 78 02/26/02 2/14 Ulcer Site Of Application 36 01/15/02 93 03/13/02 9/14 Irritation Site Of Application REMOVED ** CID 116 ** REASON - TSAC 93 03/13/02 Irritation Site Of Application NTP EXP/TEST: 95003-03 METHYL TRANS-STYRYL KETONE PAGE: 14 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 06/22/05 ROUTE: SKIN APPLICATION EISRPT37 TIME: 08:57:27 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 12 ROOM/AREA: 39 FIRST DOSE: 12/11/01 SEX: FEMALE TRT: 350 MG/KG PROCEDURE SET: 2 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 117 117 8 12/18/01 93 03/13/02 3/14 Thickened Site Of Application 29 01/08/02 93 03/13/02 10/14 Irritation Site Of Application REMOVED ** CID 117 ** REASON - TSAC 93 03/13/02 Thickened Site Of Application 93 03/13/02 Irritation Site Of Application 118 118 8 12/18/01 93 03/13/02 3/14 Thickened Site Of Application 78 02/26/02 93 03/13/02 3/14 Ulcer Site Of Application 29 01/08/02 93 03/13/02 10/14 Irritation Site Of Application REMOVED ** CID 118 ** REASON - TSAC 93 03/13/02 Ulcer Site Of Application 93 03/13/02 Thickened Site Of Application 93 03/13/02 Irritation Site Of Application 119 119 8 12/18/01 16 12/26/01 2/14 Thickened Site Of Application 29 01/08/02 93 03/13/02 9/14 Irritation Site Of Application REMOVED ** CID 119 ** REASON - TSAC 93 03/13/02 Irritation Site Of Application 120 120 29 01/08/02 93 03/13/02 10/14 Irritation Site Of Application 8 12/18/01 16 12/26/01 2/14 Thickened Site Of Application REMOVED ** CID 120 ** REASON - TSAC 93 03/13/02 Irritation Site Of Application NTP EXP/TEST: 95003-03 METHYL TRANS-STYRYL KETONE PAGE: 15 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 06/22/05 ROUTE: SKIN APPLICATION EISRPT37 TIME: 08:57:27 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 24 ROOM/AREA: 39 FIRST DOSE: 12/11/01 SEX: FEMALE TRT: 350 MG/KG PROCEDURE SET: 4 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP. NTP EXP/TEST: 95003-03 METHYL TRANS-STYRYL KETONE PAGE: 16 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 06/22/05 ROUTE: SKIN APPLICATION EISRPT37 TIME: 08:57:27 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 1 ROOM/AREA: 39 FIRST DOSE: 12/10/01 SEX: MALE TRT: VEHICLE CONTROL PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP. NTP EXP/TEST: 95003-03 METHYL TRANS-STYRYL KETONE PAGE: 17 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 06/22/05 ROUTE: SKIN APPLICATION EISRPT37 TIME: 08:57:27 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 13 ROOM/AREA: 39 FIRST DOSE: 12/10/01 SEX: MALE TRT: CONTROL SPECIAL PROCEDURE SET: 3 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP. NTP EXP/TEST: 95003-03 METHYL TRANS-STYRYL KETONE PAGE: 18 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 06/22/05 ROUTE: SKIN APPLICATION EISRPT37 TIME: 08:57:27 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 2 ROOM/AREA: 39 FIRST DOSE: 12/10/01 SEX: MALE TRT: 22.0 MG/KG PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP. NTP EXP/TEST: 95003-03 METHYL TRANS-STYRYL KETONE PAGE: 19 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 06/22/05 ROUTE: SKIN APPLICATION EISRPT37 TIME: 08:57:27 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 14 ROOM/AREA: 39 FIRST DOSE: 12/10/01 SEX: MALE TRT: 22.0 MG/KG PROCEDURE SET: 3 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP. NTP EXP/TEST: 95003-03 METHYL TRANS-STYRYL KETONE PAGE: 20 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 06/22/05 ROUTE: SKIN APPLICATION EISRPT37 TIME: 08:57:27 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 3 ROOM/AREA: 39 FIRST DOSE: 12/10/01 SEX: MALE TRT: 44.0 MG/KG PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 24 24 57 02/04/02 57 02/04/02 1/14 Irritation Site Of Application REMOVED ** CID 24 ** REASON - TSAC 93 03/12/02 Unremarkable 26 26 57 02/04/02 57 02/04/02 1/14 Irritation Site Of Application REMOVED ** CID 26 ** REASON - TSAC 93 03/12/02 Unremarkable 27 27 72 02/19/02 72 02/19/02 1/14 Irritation Site Of Application REMOVED ** CID 27 ** REASON - TSAC 93 03/12/02 Unremarkable 28 28 78 02/25/02 85 03/04/02 2/14 Irritation Site Of Application REMOVED ** CID 28 ** REASON - TSAC 93 03/12/02 Unremarkable 30 30 85 03/04/02 85 03/04/02 1/14 Irritation Site Of Application REMOVED ** CID 30 ** REASON - TSAC 93 03/12/02 Unremarkable NTP EXP/TEST: 95003-03 METHYL TRANS-STYRYL KETONE PAGE: 21 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 06/22/05 ROUTE: SKIN APPLICATION EISRPT37 TIME: 08:57:27 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 15 ROOM/AREA: 39 FIRST DOSE: 12/10/01 SEX: MALE TRT: 44.0 MG/KG PROCEDURE SET: 3 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP. NTP EXP/TEST: 95003-03 METHYL TRANS-STYRYL KETONE PAGE: 22 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 06/22/05 ROUTE: SKIN APPLICATION EISRPT37 TIME: 08:57:27 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 4 ROOM/AREA: 39 FIRST DOSE: 12/10/01 SEX: MALE TRT: 87.5 MG/KG PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 31 31 85 03/04/02 85 03/04/02 1/14 Irritation Site Of Application REMOVED ** CID 31 ** REASON - TSAC 93 03/12/02 Unremarkable 34 34 72 02/19/02 78 02/25/02 2/14 Irritation Site Of Application REMOVED ** CID 34 ** REASON - TSAC 93 03/12/02 Unremarkable 35 35 22 12/31/01 78 02/25/02 2/14 Irritation Site Of Application REMOVED ** CID 35 ** REASON - TSAC 93 03/12/02 Unremarkable 36 36 22 12/31/01 85 03/04/02 4/14 Irritation Site Of Application REMOVED ** CID 36 ** REASON - TSAC 93 03/12/02 Unremarkable 37 37 22 12/31/01 29 01/07/02 2/14 Irritation Site Of Application REMOVED ** CID 37 ** REASON - TSAC 93 03/12/02 Unremarkable 38 38 22 12/31/01 78 02/25/02 4/14 Irritation Site Of Application REMOVED ** CID 38 ** REASON - TSAC 93 03/12/02 Unremarkable 39 39 22 12/31/01 85 03/04/02 3/14 Irritation Site Of Application REMOVED ** CID 39 ** REASON - TSAC 93 03/12/02 Unremarkable 40 40 22 12/31/01 29 01/07/02 2/14 Irritation Site Of Application REMOVED ** CID 40 ** REASON - TSAC 93 03/12/02 Unremarkable NTP EXP/TEST: 95003-03 METHYL TRANS-STYRYL KETONE PAGE: 23 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 06/22/05 ROUTE: SKIN APPLICATION EISRPT37 TIME: 08:57:27 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 16 ROOM/AREA: 39 FIRST DOSE: 12/10/01 SEX: MALE TRT: 87.5 MG/KG PROCEDURE SET: 3 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP. NTP EXP/TEST: 95003-03 METHYL TRANS-STYRYL KETONE PAGE: 24 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 06/22/05 ROUTE: SKIN APPLICATION EISRPT37 TIME: 08:57:27 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 5 ROOM/AREA: 39 FIRST DOSE: 12/10/01 SEX: MALE TRT: 175 MG/KG PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 41 41 22 12/31/01 93 03/12/02 10/14 Irritation Site Of Application 36 01/14/02 36 01/14/02 1/14 Thickened Site Of Application REMOVED ** CID 41 ** REASON - TSAC 93 03/12/02 Irritation Site Of Application 42 42 22 12/31/01 93 03/12/02 8/14 Irritation Site Of Application REMOVED ** CID 42 ** REASON - TSAC 93 03/12/02 Irritation Site Of Application 43 43 15 12/24/01 15 12/24/01 1/14 Thickened Site Of Application 22 12/31/01 93 03/12/02 9/14 Irritation Site Of Application REMOVED ** CID 43 ** REASON - TSAC 93 03/12/02 Irritation Site Of Application 44 44 22 12/31/01 93 03/12/02 9/14 Irritation Site Of Application 22 12/31/01 93 03/12/02 3/14 Ulcer Site Of Application 15 12/24/01 15 12/24/01 1/14 Thickened Site Of Application REMOVED ** CID 44 ** REASON - TSAC 93 03/12/02 Ulcer Site Of Application 93 03/12/02 Irritation Site Of Application 45 45 15 12/24/01 93 03/12/02 10/14 Irritation Site Of Application 22 12/31/01 22 12/31/01 1/14 Thickened Site Of Application REMOVED ** CID 45 ** REASON - TSAC 93 03/12/02 Irritation Site Of Application 46 46 78 02/25/02 78 02/25/02 1/14 Thickened Site Of Application 22 12/31/01 93 03/12/02 9/14 Irritation Site Of Application REMOVED ** CID 46 ** REASON - TSAC 93 03/12/02 Irritation Site Of Application 47 47 22 12/31/01 93 03/12/02 8/14 Irritation Site Of Application REMOVED ** CID 47 ** REASON - TSAC 93 03/12/02 Irritation Site Of Application NTP EXP/TEST: 95003-03 METHYL TRANS-STYRYL KETONE PAGE: 25 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 06/22/05 ROUTE: SKIN APPLICATION EISRPT37 TIME: 08:57:27 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 5 ROOM/AREA: 39 FIRST DOSE: 12/10/01 SEX: MALE TRT: 175 MG/KG PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 48 48 22 12/31/01 93 03/12/02 9/14 Irritation Site Of Application 85 03/04/02 93 03/12/02 2/14 Ulcer Site Of Application REMOVED ** CID 48 ** REASON - TSAC 93 03/12/02 Ulcer Site Of Application 93 03/12/02 Irritation Site Of Application 49 49 22 12/31/01 93 03/12/02 8/14 Irritation Site Of Application REMOVED ** CID 49 ** REASON - TSAC 93 03/12/02 Irritation Site Of Application 50 50 15 12/24/01 78 02/25/02 2/14 Thickened Site Of Application 22 12/31/01 93 03/12/02 8/14 Irritation Site Of Application 72 02/19/02 85 03/04/02 3/14 Ulcer Site Of Application REMOVED ** CID 50 ** REASON - TSAC 93 03/12/02 Irritation Site Of Application NTP EXP/TEST: 95003-03 METHYL TRANS-STYRYL KETONE PAGE: 26 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 06/22/05 ROUTE: SKIN APPLICATION EISRPT37 TIME: 08:57:27 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 17 ROOM/AREA: 39 FIRST DOSE: 12/10/01 SEX: MALE TRT: 175 MG/KG PROCEDURE SET: 3 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP. NTP EXP/TEST: 95003-03 METHYL TRANS-STYRYL KETONE PAGE: 27 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 06/22/05 ROUTE: SKIN APPLICATION EISRPT37 TIME: 08:57:27 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 6 ROOM/AREA: 39 FIRST DOSE: 12/10/01 SEX: MALE TRT: 350 MG/KG PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 51 51 8 12/17/01 15 12/24/01 2/14 Thickened Site Of Application 22 12/31/01 93 03/12/02 11/14 Irritation Site Of Application REMOVED ** CID 51 ** REASON - TSAC 93 03/12/02 Irritation Site Of Application 52 52 22 12/31/01 93 03/12/02 10/14 Irritation Site Of Application REMOVED ** CID 52 ** REASON - TSAC 93 03/12/02 Irritation Site Of Application 53 53 8 12/17/01 93 03/12/02 4/14 Thickened Site Of Application 72 02/19/02 72 02/19/02 1/14 Ulcer Site Of Application 22 12/31/01 93 03/12/02 11/14 Irritation Site Of Application REMOVED ** CID 53 ** REASON - TSAC 93 03/12/02 Thickened Site Of Application 93 03/12/02 Irritation Site Of Application 54 54 22 12/31/01 93 03/12/02 8/14 Irritation Site Of Application 8 12/17/01 8 12/17/01 1/14 Thickened Site Of Application REMOVED ** CID 54 ** REASON - TSAC 93 03/12/02 Irritation Site Of Application 55 55 22 12/31/01 93 03/12/02 11/14 Irritation Site Of Application 8 12/17/01 8 12/17/01 1/14 Thickened Site Of Application REMOVED ** CID 55 ** REASON - TSAC 93 03/12/02 Irritation Site Of Application 56 56 8 12/17/01 22 12/31/01 3/14 Thickened Site Of Application 22 12/31/01 93 03/12/02 11/14 Irritation Site Of Application REMOVED ** CID 56 ** REASON - TSAC 93 03/12/02 Irritation Site Of Application 57 57 22 12/31/01 93 03/12/02 10/14 Irritation Site Of Application 8 12/17/01 8 12/17/01 1/14 Thickened Site Of Application REMOVED ** CID 57 ** REASON - TSAC 93 03/12/02 Irritation Site Of Application NTP EXP/TEST: 95003-03 METHYL TRANS-STYRYL KETONE PAGE: 28 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 06/22/05 ROUTE: SKIN APPLICATION EISRPT37 TIME: 08:57:27 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 6 ROOM/AREA: 39 FIRST DOSE: 12/10/01 SEX: MALE TRT: 350 MG/KG PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 58 58 8 12/17/01 8 12/17/01 1/14 Thickened Site Of Application 22 12/31/01 93 03/12/02 11/14 Irritation Site Of Application REMOVED ** CID 58 ** REASON - TSAC 93 03/12/02 Irritation Site Of Application 59 59 15 12/24/01 93 03/12/02 12/14 Irritation Site Of Application 8 12/17/01 93 03/12/02 2/14 Thickened Site Of Application REMOVED ** CID 59 ** REASON - TSAC 93 03/12/02 Thickened Site Of Application 93 03/12/02 Irritation Site Of Application 60 60 22 12/31/01 93 03/12/02 10/14 Irritation Site Of Application 72 02/19/02 78 02/25/02 2/14 Ulcer Site Of Application 8 12/17/01 93 03/12/02 5/14 Thickened Site Of Application REMOVED ** CID 60 ** REASON - TSAC 93 03/12/02 Thickened Site Of Application 93 03/12/02 Irritation Site Of Application NTP EXP/TEST: 95003-03 METHYL TRANS-STYRYL KETONE PAGE: 29 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 06/22/05 ROUTE: SKIN APPLICATION EISRPT37 TIME: 08:57:27 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 18 ROOM/AREA: 39 FIRST DOSE: 12/10/01 SEX: MALE TRT: 350 MG/KG PROCEDURE SET: 3 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP. ----------------------------------- ---------- END-OF-REPORT ---------- -----------------------------------