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Liaohai Chen

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Publications

  1. Chad Knutson, Gil Benko, Tristan Rocheleau, Fouzi Mouffouk, Jerzy Maselko, Liaohai Chen, Andrew Shreve and Steen Rasmussen “Metabolic Photofragmentation kinetics for a minimal Protocell: Rate-Limiting Factors, Efficiency, and Implications for Evolution”  Artificial Life 2008, 14, 189-201.
  2. Dengli Qiu, Jialing Xiang, Zhaoxia Li, Aparna Krishnamoorthy, Liaohai Chen and Rong Wang “Profiling TRA-1-81 antigen distribution on a human embryonic stem cell”  Biolchem. Biophys. Res. Com.  2008, 369, 735-740.
  3. Fouzi Mouffouk, Yasmin Chishti, Qiaoling Jin, Michelle E. Rosa, Melixa Rivera, Siva Dasa and Liaohai Chen  “Polymeric micelle-based bioassay with femtomolar sensitivity”  Analytic Biochemistry, 2008, 372, 140.
  4. John Bahns, A. Imre, V. K. Vlasko, Liaohai Chen, U. Welp  Enhances Raman scattering from focused surface plasmons.  Applied Physics Letters, 2007, 91, 081104.
  5. Axel Hoffmann, Seok-Hwan Chung, Samuel D. Bader, Lee Makowski, and  Liaohai Chen Brownian Motion in Biological Sensing in:  Biomedical Applications of Nanotechnology, edited by Vinod  Labhasetwar and Diandra L. Leslie Pelecky, (Wiley, New York, 2007), p. 83–103
  6. Seok-Hwan Chung, Axel Hoffmann, Liaohai Chen, Shouheng Sun, Konstantin Guslienko, Marcos Grimsditch, and Samuel D. Bader, Substrate-free Biosensing using Brownian Rotation of Bio-conjugated Magnetic Nanoparticles, Journal of Magnetics 2006, 11(4), 189-194.
  7. John T. Bahns, Funing Yan, Dengli Qiu, Rong Wang and Liaohai Chen “Hole-Enhanced Raman Scattering”  Applied Spectroscopy, 2006,  60, 989-993(5).
  8. Yuexing Zhang, John T. Bahns, Qiaoling Jin, Ralu Divan, and Liaohai Chen “Towards the Detection of Single Virus Particle in Serum”, Analytic Biochemistry, 2006, 356, 161-170.
  9. PASCALE EHRENFREUND, STEEN RASMUSSEN, JAMES CLEAVES and LIAOHAI CHEN  “Experimentally tracing the Key steps in the origin of Life: The Aromatic World”, ASTROBIOLOGY, 2006, Vol. 6, No. 3: 490-5203.
  10. Chinmei Liu, Seok-Hwan Chung, Qiaoling Jin, April Sutton, Funing Yan, Axel Hoffmann, Brian K. Kay, Samuel D. Bader, Lee Makowski and Liaohai Chen “Magnetic viruses via nano-capsid templates”, Journal of Magnetism and Magnetic Materials, 2006, 302, 47-51.
  11. S.-H. Chung, A. Hoffmann, K. Guslienko, S. D. Bader, C. Liu, B. Kay, L. Makowski, and L. Chen, Biological sensing with magnetic nanoparticles using Brownian relaxation (invited), J. Appl. Phys. 2005, 97, 10R101. 
  12. Chin-Mei Liu, Qiaoling Jin, April Sutton, and Liaohai Chen, A novel fluorescent probe:  Europium complex hybridized T7 phage,  Bio-conjugation Chem.  2005, 16, 1054 -1057.
  13. K. E. Achyuthan, T. S. Bergstedt, L. Chen, R. M. Jones, S. Kumaraswamy, S. A. Kushon, K. D. Ley, L. Lu, D. McBranch, H. Mukundan, F. Rininsland, X. Shi, W. Xia and D. G. Whitten  Fluorescence superquenching of conjugated polyelectrolytes: applications for biosensing and drug discovery   Journal of Materials Chemistry, 2005, 15, 2648–2656.
  14. S.-H. Chung, A. Hoffmann, K. Guslienko, S. D. Bader, C. Liu, B. Kay, L. Makowski, and L. Chen, Biological sensing with magnetic nanoparticles using Brownian relaxation (invited), J. Appl. Phys. 2005, 97, 10R101. 
  15. Qiling Tang, Yuexing Zhang, Liaohai Chen, Funing Yan and Rong Wang   Protein delivery with nanoscale precision   Nanotechnology (2005) 16 1062-1068.
  16. Dalvi-Malhotra, J.; Chen, Liaohai  Enhanced Conjugated Polymer Fluorescence Quenching by Dipyridinium-Based Quenchers in the Presence of Surfactant   J. Phys. Chem. B. ; 2005; 109(9); 3873-3878.
  17. Funing Yan, Qiling Tang, Rong Wang, and Liaohai Chen,  “Synthesis and characterization of a photo-cleavable cross-linker and its application on tunable surface modification and protein photo-delivery”,  Bio-conjugation Chem. 2004, 15,1030-1036.
  18. John T. Bahns, Chin-Mei Liu, and Liaohai Chen,  “Characterizing specific phage-protein interactions by fluorescence correlation spectroscopy” Protein Science 2004, 13, 2578-2587.
  19. S. H.  Chung, A. Hoffmann and S. D. Bader, C. Liu, B. Kay and L. Makowski and Liaohai Chen,  “Biological sensors based on Brownian relaxation of magnetic nanoparticles” Apply Phys. Lett., 2004, 85, 2971-2973.
  20. Rong Wang, Jeane Shi, Atul N. Parikh, Andrew P. Shreve, Liaohai Chen and Basil I. Swanson “Evidence for cholera aggregation on GM1-decorated lipid bilayers”, Colloids and Surfaces B: Biointerfaces, 2004 (33)  45-51
  21. Steen Rasmussen, Liaohai Chen, Barbel Stadler and Peter Stadler,  “Proto-organism kinetics: evolutionary dynamics of lipid aggregates with gene and metabolism”, Origins of Life and Evol. of The Biosp. 2004 (34), 171.
  22. Steen Rasussen, Liaohai Chen, David Deamer, David Krakauer, Norman Packard, Peter Stadler and Mark Bedau   “Transitions from nonliving to living Matter” Science  2004 (303), 963-965.
  23. Steen Rasmussen ; Liaohai Chen ; Martin Nilsson ; Shigeaki Abe, “Bridging Nonliving and Living Matter”, Artificial Life, 2003 (9), 3, 269 – 316.
  24. Shigeaki Abe and Liaohai Chen, “Tuning the photophysical properties of an ionic conjugated polymer through interaction with polyelectrolytes”,  J. Polymer science: Part B: polymer physics, 2003 (41), 1676-1679.
  25. Hsing-lin Wang, Duncan McBranch, Liaohai Chen, Fred Wudl "Highly efficient energy and charge transfer in thin self-assembled mutilayered polymer films"  Synthetic Metals, (2001), 121, 1367.
  26. Liaohai Chen, Su Xu, Duncan McBranch, and David Whitten  "Tuning the Properties of Conjugated Polyelectrolytes Through Surfactant Complexation" J. Am. Chem. Soc.  (2000), 122,  9302-9303.
  27. Liaohai Chen, Rong Wang, Duncan McBranch, and David Whitten  "Surfactant-Induced Modification of Quenching of Conjugated Polymer Fluorescence by Electron Acceptors:  Applications for Chemical Sensing"   Chem. Phy. Lett.  (2000), 330, 27-33.
  28. Rong Wang, Cristina Geiger, Liaohai Chen, Basil Swanson, David G. Whitten  "Direct Observation of Sol-Gel Conversion: the Role of the Solvent in Organogel Formation"  J. Am. Chem. Soc.  (2000), 122(10),  2399-2400.
  29. Liaohai Chen, Cristina Geiger, Jerry Perlstein and David G. Whitten   "Self-Assembly of Styryl Naphthalene Amphiphiles in Aqueous Dispersions and Interfacial Films: Aggregate Structure, Assembly Properties, Photochemistry and Photophysics" J. Phys. Chem. B  (1999), 103(43), 9161-9167.
  30. Cristina Geiger, Marina Stanescu, Liaohai Chen, and David G. Whitten   Organogels Resulting from Competing Self-AssemblyUnits in the Gelator: Structure, Dynamics, and Photophysical Behavior of Gels Formed from Cholesterol-Stilbene and Cholesterol-Squaraine Gelators, Langmuir (1999), 15, 2241-2245.
  31. Liaohai Chen, Duncan W. McBranch, Hsing-Lin Wang, Roger Helgeson, Fred Wudl, and David G. Whitten   "Highly-Sensitive Biological and Chemical Sensors Based on Reversible Fluorescence Quenching in a Conjugated Polymer" "  Proc. Nat. Acad. Sci. (1999), 22, 12287-12292.
  32. Whitten, David G.; Liaohai Chen; Geiger, H. Cristina; Perlstein, Jerry; Song, Xuedong. "Self-Assembly of Aromatic-Functionalized Amphiphiles: The Role and Consequences of Aromatic-Aromatic Noncovalent Interactions in Building Supramolecular Aggregates and Novel Assemblies"   Feature Article J. Phys. Chem. B (1998), 102(50), 10098-10111.
  33. Liaohai Chen; Lucia, Lucian A.; Gaillard, E. R.; Whitten, David G.; Icil, H.; Icli, S.  “Photooxidation of a Conjugated Diene by an Exciplex Mechanism: Amplification via Radical Chain Reactions in the Perylene Diimide-Photosensitized Oxidation of a-Terpinene”   J. Phys. Chem. A (1998), 102(45), 9095-9098.
  34. Lucia, Lucian A.; Wyrozebski, Kataryna; Liaohai Chen; Geiger, Cristina; Whitten, David G.  “Electron Transfer Photofragmentation Reactions in Monolayer Films at the Air/Water Interface” Langmuir (1998), 14(13), 3663-3672.
  35. Liaohai Chen; Lucia, Lucian; Whitten, David G.  “Cooperative Electron Transfer Fragmentation Reactions. Amplification of a Photoreaction through A Tandem Chain Fragmentation of Acceptor and Donor Pinacols”  J. Am. Chem. Soc. (1998), 120(2), 439-440.
  36. Liaohai Chen; Farahat, Mohammad S.; Gaillard, Elizabeth R.; Farid, Samir; Whitten, David G.  “Photoinduced Electron Transfer Double Fragmentation: an Oxygen-Mediated Radical Chain Process in the Co-fragmentation of Substituted Pinacol Donors with Carbon Tetrachloride”   J. Photochem. Photobiol., A (1996), 95(1), 21-5.
  37. Liaohai Chen; Farahat, Mohammad S.; Gan, Hong; Farid, Samir; Whitten, David G.  “Photoinduced Electron Transfer Double Fragmentation: An Oxygen-Mediated Radical Chain Process in the Cofragmentation of Aminopinacol Donors with Organic Halides”   J. Am. Chem. Soc. (1995), 117(23), 6398-6399.
  38. Liaohai Chen, Wanzhen Gu et al. " Highly Efficient Hydrogen and Ethylene Glycol Photoproduction From Aqueous Methanol Solution by ZnS and an in Situ Spin Trapping Investigation  "   J. Photochemistry and Photobiology: A. Chem: (1993), 74, 85-89.
  39. Liaohai Chen, Wanzhen Gu et al. " Photoproduction of Hydrogen and 1,2-Propanediol From Aqueous Methanol and Ethanol Solution Catalyzed by ZnS "  J. Photochemistry and Photobiology: A. Chem: (1993), 73, 217-220.

 

Patents

  1. Liaohai Chen  “AN IMPROVED METHOD FOR THE USE OF CA 125 FOR OVARIAN CANCER DIAGNOSIS” Patent disclosure (ANL-IN-07-005), provisional patent was filed October, 2007.
  2. Liaohai Chen  “Polymeric micelle-based bioassay with femtomolar sensitivity” Patent disclosure (ANL-IN-07-006), provisional patent was filed November, 2007..
  3. Liaohai Chen, A. Hoffmann, S. D. Bader, B. Kay and L. Makowski  “Nanosized biological container and manufacture thereof”  US Patent 20060240456 -
  4. Chen, Liaohai “Enhanced photophysics of conjugated polymers” US patent (2003) 0224525.
  5. Chen, Liaohai; Xu, Su; McBranch, Duncan; Whitten, David. “Enhanced photophysics of conjugated polymers, complex with surfactants, their manufacture and fluorescent propertie” U.S. Patent (2003) 6569952.
  6. Chen, Liaohai,  "Tuning the properties of ionic conjugated polymer with polyelectrolytes and application in a biosensor platform".  Patent number WO (2002) 2002079268.
  7. Chen, Liaohai; McBranch, Duncan W.; Wang, Hsing-Lin; Whitten, David G.  "Method for detecting biological agents". Patent number  WO (2000) 2000066790.  The patent has led to the establishment of QTL Biosystems at Santa Fe, New Mexico and the sensor device was the candidate for 2000 R&D 100 award.

 

Book Chapters

  1. Axel Hoffmann, Seok-Hwan Chung, Samuel D. Bader, Lee Makowski and Liaohai Chen, Chapter 1, BROWNIAN MOTION IN BIOLOGICAL SENSING.  BIOMEDICAL APPLICATIONSOF NANOTECHNOLOGY, A JOHN WILEY & SONS, INC., 2005
  2. David Whitten, Liaohai Chen, Robert Jones, and Peter Heeger  Chapter 4:  From Superquenching to biodetection: Building sensors based on fluorescent polyelectrolytes  Optical Sensors and Switches,  Marcel Dekker, Inc. 2001.
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