National Toxicology Program

CASRN: 1896-62-4

Related: METHYL STYRYL KETONE (122-57-6)

Formula: C10 H10 O

Synonyms/Common Names:

• 3-BUTEN-2-ONE,4-PHENYL,(Z)- (9CI)
• TRANS-METHYL STYRYL KETONE
• TRANS-BENZALACETONE
• TRANS-4-PHENYL-3-BUTEN-2-ONE

Known Uses:

REACTIVE CARBONYL COMPOUND USED IN ORGANIC SYNTHETIC REACTIONS SUCH AS INTERMEDIATE IN ORGANIC SYNTHESIS, ELECTROPLATING CHEMICAL; PHARMACEUTICAL INTERMEDIATE, BIOCHEMICAL REAGENT, AGRICULTURAL CHEMICAL INTERMEDIATE, PROPOSED SUNSCREEN INTERMEDIATE. USED AS FLAVORING & FRAGRANCE ADDITIVE.

Nomination Background

Short-Term Toxicity

• 13-WEEK (Dosed-Feed)  (C95003B) Subchronic Toxicology Review 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, .025, .05, .1, .2, OR .4%; 10/SEX/SPECIES/DOSE
• 13-WEEK (Topical Application)  (C95003) Subchronic Toxicology Review 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0, 22, 44, 87.5, 175, OR 350 MG/KG M: 0, 87.5, 175, 350, 700, OR 1400 MG/KG; 10/SEX/SPECIES/DOSE

Long-Term Carcinogenicity

• 2-YEAR (Topical Application)  (C95003C) Histopathology 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 10, 30, OR 90 MG/KG; 50/SEX/SPECIES/DOSE

Special Studies

• Absorption Disposition Metabolism Elimination (Topical Application; Gavage; Intravenous)  (S0605) Completed 
  • Citation: SAUER ET AL., DRUG METABOLISM AND DISPOSITION 1997 VOL 25 (6) PG 732 ORAL AND TOPICAL ABSORPTION, DISPOSITION KINETICS, AND THE METABOLIC FATE OF T-METHYL STYRYL KETONE IN THE MALE FISHER 344 RAT SAUER ET AL., DRUG METABOLISM AND DISP 1997 VOL 25: 1184. ABSORPTIONDISPOSITION, AND METABOLISM OF TRANS-METHYL STYRYL KETONE IN FEMALE B6C3F1 MICE.
  • M/F Rats: F344/N; M/F Mice: B6C3F1; M/F Rats: F344/N; M/F Mice: B6C3F1; M/F Rats: F344/N; M/F Mice: B6C3F1
• Absorption Disposition Metabolism Elimination (Intravenous)  (S0843) Completed 
  • Citation: FINAL REPORT: CHEMICAL DISPOSITION IN MAMMALS, 03/15/98 - 06/30/99. I.G. SIPES. J.L. BURKEY, M.J. KATTNIG. DEPARTMENT OF PHARMACOLOGY AND TOXICOLOGY, CENTER FOR TOXICOLOGY, COLLEGE OF PHARMACY, THE UNIVERSITY OF ARIZONA, TUCSON, ARIZONA 85721.
  • M Rats: F344/N
  • Dose: 20 mg/kg; 120 uCi/ml or 20 mg/kg; 10 uCi/ml in methyl cellulose emulphor:ethanol:saline, 3:4:12 (v/v/v)
• Metabolism (Intravenous; Gavage; Topical Application)  (S0804) Completed 
  • Citation: ORAL AND TOPICAL ABSORPTION, DISPOSITION KINETICS, AND THE METABOLIC FATE OF TRANS-METHYL STYRL KETONE IN THE MALE FISCHER 344 RAT. J-M. SAUER ET AL., 1997.
  • M Rats: F344/N; M Rats: F344/N; M Rats: F344/N
  • Dose: IV admin: [14C]MSK (20 mg/kg, 120 uCi/kg) in emulphor/ethanol/saline(3:4:12, v/v/v); Oral admin: [14C]MSK (200 mg/kg, 100 uCi/kg) in 0.5% methyl cellulose (5 ml/kg); Dermal admin: 100 ul of [14C]MSK (250 mg/kg, 50 uCi/kg) in acetone
• Metabolism (Intravenous; Gavage; Topical Application)  (S0805) Completed 
  • Citation: ABSORPTION, DISPOSITION, AND METABOLISM OF TRANS-METHYL STYRL KETONE IN FEMALE B6C3F1 MICE. DRUG METABOLISM AND DISPOSITION, VOL. 25, NO. 10, 1184-1190. J-M. SAUER ET AL., 1997
  • F Mice: B6C3F1; F Mice: B6C3F1; F Mice: B6C3F1
  • Dose: [14C]MSK (20 mg/kg, 120 uCi/kg), in emulphor:ethanol:saline, 3:4:12 (v/v/v) was administered via the tail vein (4 ml/kg) - I.V. admin.; [14C]MSK (200 mg/kg, 100 uCi/kg) in 0.5% methyl cellulose (5 ml/kg) was administered orally by gavage; [14C]MSK (250 mg/kg, 50 uCi/kg) in 10 ul acetone - topical (dermal) admin

Genetic Toxicology

• Micronucleus  (A86423) Completed 
  • Mice: B6C3F1
  • Male Negative 
  • Female Negative 
• Micronucleus  (A92009) Completed 
  • Mice: B6C3F1
  • Male Negative 
  • Female Negative 
• Salmonella  (A17064) Completed 
  •  Positive