Picard C, Salmon D, Fegueux S, Longuet P, Sauvage C, Gilquin J, Desmoulins T; International Conference on AIDS.
Int Conf AIDS. 1990 Jun 20-23; 6: 232 (abstract no. Th.B.440).
Hopital Bichat-Claude Bernard, Paris, France
OBJECTIVE: To describe a new side effect of F observed in AIDS patients (pts). METHODS: Between 1985 and 1989, AIDS pts who developed G.U under F therapy for CMV retinitis, were evaluated with biological, viral, bacteriological and histological investigations. RESULTS: Eleven homosexual men, mean age 38 years, developed erosive, bullous, tender ulcerations of glans penis and cervix glandis, size 1-5 cm, number 2-5. Oral localisations were associated in 4/11. Eight/11 had previous Kaposi sarcoma. Mean duration of AIDS was 16 months (1-37). Viral cultures were negative in 8/8, histology showed inflammatory infiltrate in 3/3, without viral inclusion. Neutrophil count was 1080 mm3 (400-1530), CD4 count 6 mm3 (2-11). Renal function was normal in 11/11. Other treatment included sulfamid 4/11. Lesions appeared in 7/11 during first induction after 16 days (10-27); 2/11 during maintenance therapy after 9 and 178 days; 2/11 during ulterior induction therapy after 11 and 15 days. Treatment was stopped in 7/11 because of pain: healing was obtained in 7/7 after 6 to 12 days. Reintroduction induced relapse in 2/2 after 2 days; there was no healing when treatment was maintained. CONCLUSION: Imputability criteria (delay of occurrence, healing after treatment interruption, relapse with reintroduction, absence of other etiology) suggest that G.U are a F. related eruption. Frequency of this previously undescribed side-effect of F. has to be estimated prospectively.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- CD4 Lymphocyte Count
- Cytomegalovirus Retinitis
- Drug Therapy, Combination
- Female
- Female Urogenital Diseases
- Foscarnet
- Humans
- Male
- drug therapy
- therapy
Other ID:
UI: 102182017
From Meeting Abstracts