Testing Information

Testing Status of Agents at NTP

C.I. Basic red 9 monohydrochloride

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http://ntp.niehs.nih.gov/go/TS-10633-C

CASRN: 569-61-9

Related: ALSO KNOWN AS P-ROSANILINE SEE ALSO 548-62-9 AND 3248-93-9

Formula: C19-H17-N3.CL-H

Synonyms/Common Names:

  • 4-((4-AMINOPHENYL)(4-IMINO-2,5-CYCLOHEXADIEN-1-YLIDENE)METHYL)-BENZENAMINE MONOHYDROCHLORIDE (9CI)
  • BASIC RED 9
  • RED 9, C.I. ACID
  • P-ROSANILINE

Known Uses:

DYE FOR TEXTILES, LEATHER, PHOTOGRAPHY AND PAPER, AND AS BIOLOGIC STAIN

Short-Term Toxicity

  • 13-WEEK (Dosed-Feed)  (C54739) Completed 
    • NTIS No. PB86-186509  (Peer Review 03/29/1985)
      Citation: Toxicology and Carcinogenesis Studies of C.I. Basic Red 9 Monohydrochloride (Pararosaniline) (CAS No. 569-61-9) In F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 250, 500, 1000, 2000, OR 4000 PPM; 10/SEX/SPECIES

Long-Term Carcinogenicity

  • 2-YEAR (Dosed-Feed)  (C54739) Report Complete 
    • TR-285 (NTIS No. PB86-186509)  (Peer Review 03/29/1985)
      Toxicology and Carcinogenesis Studies of C.I. Basic Red 9 Monohydrochloride (Pararosaniline) (CAS No. 569-61-9) In F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: MR: 0, 1000, OR 2000 PPM -- FR AND M&F MICE 0, 500, OR 1000 PPM; 50/SEX/SPECIES

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (365437) Completed 
    • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
    • Chromosome Aberation Not Tested 
    • Sister Chromatid Exchange Negative 
  • In Vitro Cytogenetics (CA/SCE)  (724892) Completed 
    • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
    • Chromosome Aberation Negative 
    • Sister Chromatid Exchange Not Tested 
  • Mouse Lymphoma (NCI)  (G61721) Completed 
    • Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
    • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
    • Mouse Lymphoma-NCI  Inconclusive 
  • Mouse Lymphoma (NCI)  (G90579) Completed 
    • Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
    • Mouse Lymphoma-NCI  Positive 
  • Micronucleus  (A57951) Completed 
    • Rats: F344
    • Male Negative 
  • Salmonella (NCI)  (N-9143) Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escerichia coli using a standardized protocol Environ. Mutagen. Vol. 6 (Suppl 2) (1985) 1-251
    • Salmonella-NCI  Inconclusive 
  • Salmonella  (383718) Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
    •  Positive 

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Web page last updated on January 22, 2009