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Title Actions of vasoactive intestinal peptide and secretin on chief cells prepared from guinea pig stomach
Creator/Author Sutliff, V.E. ; Raufman, J.P. ; Jensen, R.T. ; Gardner, J.D.
Publication Date1986 Jul 01
OSTI IdentifierOSTI ID: 6294045
Other Number(s)CODEN: AJPHA
Resource TypeJournal Article
Resource RelationAm. J. Physiol. ; Vol/Issue: 251:1
Research OrgNational Institutes of Health, Bethesda, MD
Subject550601 -- Medicine-- Unsealed Radionuclides in Diagnostics ;551001 -- Physiological Systems-- Tracer Techniques; AMP-- SECRETION;PEPSIN-- SECRETION;PEPTIDES-- RADIORECEPTOR ASSAY;SECRETIN-- RADIORECEPTOR ASSAY; CARBON 14 COMPOUNDS;CARDIOVASCULAR AGENTS;DOSE-RESPONSE RELATIONSHIPS;GASTRIC ACID;IODINE 125;MUCOUS MEMBRANES;PHYSIOLOGY;SODIUM IODIDES;STOMACH
Related SubjectACID PROTEINASES;ALKALI METAL COMPOUNDS;BETA DECAY RADIOISOTOPES;BIOLOGICAL MATERIALS;BODY;BODY FLUIDS;DAYS LIVING RADIOISOTOPES;DIGESTIVE SYSTEM;DRUGS;ELECTRON CAPTURE RADIOISOTOPES;ENZYMES;GASTROINTESTINAL TRACT;HALIDES;HALOGEN COMPOUNDS;HORMONES;HYDROLASES;INORGANIC PHOSPHORS;INTERMEDIATE MASS NUCLEI;IODIDES;IODINE COMPOUNDS;IODINE ISOTOPES;ISOTOPE APPLICATIONS;ISOTOPES;LABELLED COMPOUNDS;MATERIALS;MEMBRANES;NUCLEI;NUCLEOTIDES;ODD-EVEN NUCLEI;ORGANIC COMPOUNDS;ORGANS;PEPTIDE HYDROLASES;PHOSPHORS;PROTEINS;RADIOISOTOPES;SODIUM COMPOUNDS;TRACER TECHNIQUES
Description/Abstract Vasoactive intestinal peptide and secretin increased cellular cAMP and pepsinogen secretion in dispersed chief cells from guinea pig gastric mucosa.^With each peptide there was a close correlation between the dose-response curve for changes in cellular cAMP and that for changes in pepsinogen secretion.^Vasoactive intestinal peptide- (10-28) and secretin- (5-27) had no agonist activity and antagonized the actions of vasoactive intestinal peptide and secretin on cellular cAMP and pepsinogen secretion.^Studies of binding of SVI-vasoactive intestinal peptide and of SV-secretin indicated that gastric chief cells possess four classes of binding sites for vasoactive intestinal peptide and secretin and that occupation of two of these classes of binding sites correlates with the abilities of vasoactive intestinal peptide and secretin to increase cellular cAMP and pepsinogen secretion.^What function, in any, is mediated by occupation by the other two classes of binding sites remains to be determined.
Country of PublicationUnited States
LanguageEnglish
FormatPages: G96-G102
System Entry Date2001 May 13

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