Abraham B, Marih L, Thevenet S, Marechal E, Verdet C, Rozenbaum W, Pialoux G; International Conference on AIDS (15th : 2004 : Bangkok, Thailand).
Int Conf AIDS. 2004 Jul 11-16; 15: abstract no. MoPeB3302.
Service de maladies infectieuses et tropicales Hopital Tenon Universite Paris 6, Paris, France
Background: Epidemiologic studies have demonstrated strong associations between syphilis and HIV infection. A outbreak of syphilis in Paris has been noted recently. We performed a retrospective study in order to assess the evolution of the incidence and describe the clinical and laboratory manifestations of syphilis among HIV patients. Methods: Data were collected retrospectively from all the patients infected by HIV followed in our unit, who presented syphilis between January 2000 and December 2002. Results: 71 patients were enrolled. The half-year incidence of syphilis among HIV patients increased progressively from 0.8 per 1000 population (1st half-year 2000) to 9.8 per 1000 population (2nd half-year 2002). The median age was 36 years old (28-56), all were men who were homo-or bisexual. HIV seropositivity was known prior to the syphilis in a median of 8 years and was discovered at the same time for 6 patients. The median CD4 cell count was 452/mm3 (17-1753) and median plasmatic HIV RNA was 2.9 log/ml (<1.7-5.7). Seventy-seven percent of the patients were under highly active anti retroviral therapy for a median of 4.6 years. Secondary syphilis was more frequent (48%), than primary (25%), latent syphilis (20%), primary-secondary (4%) and neuro-syphilis (3%). After treatment, we observed none clinical failure. During the follow-up, five percent of the patients were not considered as having a satisfactory serologic response (3/61) and twelve percent relapsed. Secondary cases were found in only 4 cases. Conclusion This study shows the dramatic increase of the syphilis among HIV homosexual men in Paris. The clinical evolution under appropriated therapy was favourable, but the number of relapse must be emphasized. This epidemic suggest a sexual relapse among this population and must be considered like a serious worning to reinforce primary and secondary prevention.
Publication Types:
Keywords:
- Academic Medical Centers
- Acquired Immunodeficiency Syndrome
- Bisexuality
- CD4 Lymphocyte Count
- Epidemiologic Studies
- HIV Infections
- HIV Seropositivity
- Homosexuality
- Hospitals, Teaching
- Humans
- Incidence
- Male
- Paris
- Retrospective Studies
- Syphilis
- Syphilis Serodiagnosis
Other ID:
UI: 102279604
From Meeting Abstracts